Protein name:
Prostatic acid phosphatase (PAP) ;
Alternative:
Ecto-5'-nucleotidase ;3.1.3.5;5'-nucleotidase (5'-NT) ;Thiamine monophosphatase (TMPase) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; dimer formation is required for phosphatase activity.
Function:
Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
Subcellular Location:
Isoform 2
Cell membrane
Single-pass type I membrane protein
Lysosome membrane
Single-pass type I membrane protein
Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.
Protein Attributes:
50:
MRAAPLLLAR | AASLSLGFLF | LLFFWLDRSV | LAKELKFVTL | VFRHGDRSPI |
100:
DTFPTDPIKE | SSWPQGFGQL | TQLGMEQHYE | LGEYIRKRYR | KFLNESYKHE |
150:
QVYIRSTDVD | RTLMSAMTNL | AALFPPEGVS | IWNPILLWQP | IPVHTVPLSE |
200:
DQLLYLPFRN | CPRFQELESE | TLKSEEFQKR | LHPYKDFIAT | LGKLSGLHGQ |
250:
DLFGIWSKVY | DPLYCESVHN | FTLPSWATED | TMTKLRELSE | LSLLSLYGIH |
300:
KQKEKSRLQG | GVLVNEILNH | MKRATQIPSY | KKLIMYSAHD | TTVSGLQMAL |
350:
DVYNGLLPPY | ASCHLTELYF | EKGEYFVEMY | YRNETQHEPY | PLMLPGCSPS |
386:
CPLERFAELV | GPVIPQDWST | ECMTTNSHQG | TEDSTD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
Polyclonal Antibody for Human PAP
Polyclonal Antibody for Human PAP
Polyclonal Antibody for Human PAP
Polyclonal Antibody for Human PAP
Monoclonal Antibody for Human PAP
Monoclonal Antibody for Human PAP
Monoclonal Antibody for Human PAP
Monoclonal Antibody for Human PAP
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;DISULFIDE BONDS;ACTIVE SITE
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
tissue :
Prostate .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Prostate .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
8.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Prostate .
9.
"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M.
,
Scherer S.E.
,
Kaul R.
,
Wang J.
,
Yu J.
,
Sudbrak R.
,
Buhay C.J.
,
Chen R.
,
Cree A.
,
Ding Y.
,
Dugan-Rocha S.
,
Gill R.
,
Gunaratne P.
,
Harris R.A.
,
Hawes A.C.
,
Hernandez J.
,
Hodgson A.V.
,
Hume J.
,
Jackson A.
,
Khan Z.M.
,
Kovar-Smith C.
,
Lewis L.R.
,
Lozado R.J.
,
Metzker M.L.
,
Milosavljevic A.
,
Miner G.R.
,
Morgan M.B.
,
Nazareth L.V.
,
Scott G.
,
Sodergren E.
,
Song X.-Z.
,
Steffen D.
,
Wei S.
,
Wheeler D.A.
,
Wright M.W.
,
Worley K.C.
,
Yuan Y.
,
Zhang Z.
,
Adams C.Q.
,
Ansari-Lari M.A.
,
Ayele M.
,
Brown M.J.
,
Chen G.
,
Chen Z.
,
Clendenning J.
,
Clerc-Blankenburg K.P.
,
Chen R.
,
Chen Z.
,
Davis C.
,
Delgado O.
,
Dinh H.H.
,
Dong W.
,
Draper H.
,
Ernst S.
,
Fu G.
,
Gonzalez-Garay M.L.
,
Garcia D.K.
,
Gillett W.
,
Gu J.
,
Hao B.
,
Haugen E.
,
Havlak P.
,
He X.
,
Hennig S.
,
Hu S.
,
Huang W.
,
Jackson L.R.
,
Jacob L.S.
,
Kelly S.H.
,
Kube M.
,
Levy R.
,
Li Z.
,
Liu B.
,
Liu J.
,
Liu W.
,
Lu J.
,
Maheshwari M.
,
Nguyen B.-V.
,
Okwuonu G.O.
,
Palmeiri A.
,
Pasternak S.
,
Perez L.M.
,
Phelps K.A.
,
Plopper F.J.
,
Qiang B.
,
Raymond C.
,
Rodriguez R.
,
Saenphimmachak C.
,
Santibanez J.
,
Shen H.
,
Shen Y.
,
Subramanian S.
,
Tabor P.E.
,
Verduzco D.
,
Waldron L.
,
Wang J.
,
Wang J.
,
Wang Q.
,
Williams G.A.
,
Wong G.K.-S.
,
Yao Z.
,
Zhang J.
,
Zhang X.
,
Zhao G.
,
Zhou J.
,
Zhou Y.
,
Nelson D.
,
Lehrach H.
,
Reinhardt R.
,
Naylor S.L.
,
Yang H.
,
Olson M.
,
Weinstock G.
,
Gibbs R.A.
more...
Nature440:1194-1198(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS ASN-15; VAL-124; ARG-226; HIS-330 AND ALA-360
tissue :
Prostate .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE OF CARBOHYDRATES
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY;ENZYME REGULATION;MUTAGENESIS OF TRP-206
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ENZYME ACTIVITY
15.
"Prostatic acid phosphatase is not a prostate specific target."
Quintero I.B.
,
Araujo C.L.
,
Pulkka A.E.
,
Wirkkala R.S.
,
Herrala A.M.
,
Eskelinen E.-L.
,
Jokitalo E.
,
Hellstroem P.A.
,
Tuominen H.J.
,
Hirvikoski P.P.
,
Vihko P.T.
Cancer Res.67:6549-6554(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
16.
"Semen-derived amyloid fibrils drastically enhance HIV infection."
Munch J.
,
Rucker E.
,
Standker L.
,
Adermann K.
,
Goffinet C.
,
Schindler M.
,
Wildum S.
,
Chinnadurai R.
,
Rajan D.
,
Specht A.
,
Gimenez-Gallego G.
,
Sanchez P.C.
,
Fowler D.M.
,
Koulov A.
,
Kelly J.W.
,
Mothes W.
,
Grivel J.C.
,
Margolis L.
,
Keppler O.T.
,
Forssmann W.G.
,
Kirchhoff F.
more...
Cell131:1059-1071(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;IDENTIFICATION BY MASS SPECTROMETRY;ROLE IN HIV INFECTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Placenta .
18.
"Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer."
Hong S.
,
Klein E.A.
,
Das Gupta J.
,
Hanke K.
,
Weight C.J.
,
Nguyen C.
,
Gaughan C.
,
Kim K.A.
,
Bannert N.
,
Kirchhoff F.
,
Munch J.
,
Silverman R.H.
J. Virol.83:6995-7003(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING;ROLE IN XMRV INFECTION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEGRADATION OF SEVI AMYLOID FIBRILS
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INHIBITION OF SEVI ACTIVITY
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
23.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) IN COMPLEX WITH N-PROPYL-L-TARTRAMATE
24.
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Cited for : X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 33-374;DISULFIDE BONDS;GLYCOSYLATION AT ASN-94 AND ASN-220
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Cited for : X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 33-386 IN COMPLEX WITH A PHOSPHATE ION AND INHIBITOR ALPHA-BENZYLAMINOBENZYLPHOSPHONIC ACID;DISULFIDE BONDS;GLYCOSYLATION AT ASN-220 AND ASN-333
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Cited for : STRUCTURE BY NMR OF 248-286