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Index > Protein center > Ace(Gene name) > Rat
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  • Ace (Gene name),
  • Angiotensin-converting enzyme (Protein name ),  ACE_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Ace(Dcp1);
    Protein name:
    Angiotensin-converting enzyme(ACE);
    Alternative:
    Dipeptidyl carboxypeptidase I;Kininase II;
    CD:
    CD143;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1313
    Sequence:
    50:
    MGAASGQRGR | WPLSPPLLML | SLLLLLLLPP | SPAPALDPGL | QPGNFSADEA | 
    100:
    GAQLFADSYN | SSAEVVMFQS | TAASWAHDTN | ITEENARLQE | EAALINQEFA | 
    150:
    EVWGKKAKEL | YESIWQNFTD | QKLRRIIGSV | QTLGPANLPL | TQRLQYNSLL | 
    200:
    SNMSRIYSTG | KVCFPNKTAT | CWSLDPELTN | ILASSRNYAK | VLFAWEGWHD | 
    250:
    AVGIPLRPLY | QDFTALSNEA | YRQDGFSDTG | AYWRSWYESP | SFEESLEHLY | 
    300:
    HQVEPLYLNL | HAFVRRALHR | RYGDKYINLR | GPIPAHLLGD | MWAQSWENIY | 
    350:
    DMVVPFPDKP | NLDVTSTMVQ | KGWNATHMFR | VAEEFFTSLG | LSPMPPEFWA | 
    400:
    ESMLEKPADG | REVVCHASAW | DFYNRKDFRI | KQCTRVTMDQ | LSTVHHEMGH | 
    450:
    VQYYLQYKDL | HVSLRRGANP | GFHEAIGDVL | ALSVSTPAHL | HKIGLLDRVA | 
    500:
    NDIESDINYL | LKMALEKIAF | LPFGYLVDQW | RWGVFSGRTP | PSRYNYDWWY | 
    550:
    LRTKYQGICP | PVARNETHFD | AGAKFHIPSV | TPYIRYFVSF | VLQFQFHQAL | 
    600:
    CKEAGHQGPL | HQCDIYQSTK | AGAKLQQVLQ | AGCSRPWQEV | LKDLVGSDAL | 
    650:
    DASALMEYFQ | PVSQWLQEQN | QRNGEVLGWP | EYQWRPPLPD | NYPEGIDLET | 
    700:
    DEAKANRFVE | EYDRTAKVLW | NEYAEANWHY | NTNITIEGSK | ILLQKNKEVS | 
    750:
    NHTLKYGTWA | KTFDVSNFQN | STIKRIIKKV | QNVDRAVLPP | NELEEYNQIL | 
    800:
    LDMETTYSVA | NVCYTNGTCL | SLEPDLTNIM | ATSRKYEELL | WVWKSWRDKV | 
    850:
    GRAILPFFPK | YVDFSNKIAK | LNGYSDAGDS | WRSSYESDDL | EQDLEKLYQE | 
    900:
    LQPLYLNLHA | YVRRSLHRHY | GSEYINLDGP | IPAHLLGNMW | AQTWSNIYDL | 
    950:
    VAPFPSAPSI | DATEAMIKQG | WTPRRIFKEA | DNFFTSLGLL | PVPPEFWNKS | 
    1000:
    MLEKPTDGRE | VVCHASAWDF | YNGKDFRIKQ | CTSVNMEELV | IAHHEMGHIQ | 
    1050:
    YFMQYKDLPV | TFREGANPGF | HEAIGDVLAL | SVSTPKHLHS | LNLLSSEGSG | 
    1100:
    YEHDINFLMK | MALDKIAFIP | FSYLIDQWRW | RVFDGSITKE | NYNQEWWSLR | 
    1150:
    LKYQGLCPPV | PRSQGDFDPG | SKFHVPANVP | YIRYFISFII | QFQFHEALCR | 
    1200:
    AAGHTGPLYK | CDIYQSKEAG | KLLADAMKLG | YSKQWPEAMK | IITGQPNMSA | 
    1250:
    SAIMNYFKPL | TEWLVTENRR | HGETLGWPEY | TWTPNTARAE | GSLPESSRVN | 
    1300:
    FLGMYLEPQQ | ARVGQWVLLF | LGVALLVATV | GLAHRLYNIH | NHHSLRRPHR | 
    1313:
    GPQFGSEVEL | RHS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat ACE
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    ELISA Kit for Rat ACE
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    ELISA Kit for Rat ACE
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    ELISA Kit for Rat ACE
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    ELISA Kit for Rat ACE
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    ELISA Kit for Rat ACE
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    CLIA Kit for Rat ACE
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    CLIA Kit for Rat ACE
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    CLIA Kit for Rat ACE
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    U0004m
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    CLIA Kit for Rat ACE
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    U0004r
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    CLIA Kit for Rat ACE
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    CLIA Kit for Rat ACE
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    U0004b
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    Polyclonal Antibody for Rat ACE
    Polyclonal Antibody for Rat ACE
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    P0004Rb-h
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    Polyclonal Antibody for Rat ACE
    Polyclonal Antibody for Rat ACE
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    P0004Rb-m
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    Polyclonal Antibody for Rat ACE
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    P0004Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat ACE
    Monoclonal Antibody for Rat ACE
    Monoclonal Antibody for Rat ACE
    Monoclonal Antibody for Rat ACE
    Monoclonal Antibody for Rat ACE
    Monoclonal Antibody for Rat ACE
    Monoclonal Antibody for Rat ACE
    Protein for Rat ACE
    Protein for Rat ACE
    Protein for Rat ACE
    Protein for Rat ACE
    Protein for Rat ACE
    Protein for Rat ACE

    R&D Technical Data
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    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.0%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.9%



     

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    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery  Range (%)

    Serum

    101

    95-107

    Plasma

    99

    93-102

     

     

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    Saliva(n=3)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    93-104%

    91-101%

    95-102%

    96-109%

    Saliva(n=3)

    90-99%

    93- 99%

    89-97%

    92-106%

    heparin plasma(n=5)

    94-103%

     

    96-110%

    99-111%

    94-110%

     

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    References
    1. 1.
      "Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme."
      Koike G. , Krieger J.E. , Jacob H.J. , Mukoyama M. , Pratt R.E. , Dzau V.J.
      Biochem. Biophys. Res. Commun.198:380-386(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SOMATIC);VARIANT LYS-207
      tissue: Lung.
    2. 2.
      "Characterization of a missense mutation in the angiotensin I-converting enzyme cDNA in exudative inflammation resistant F344/N rats."
      Jafarian-Tehrani M. , Listwak S. , Barrientos R.M. , Michaud A. , Corvol P. , Sternberg E.M.
      Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SOMATIC)
      strain: Fischer 344/N.
      strain: Lewis/N.
      tissue: Lung.
    3. 3.
      "Species-specific splicing and expression of angiotensin converting enzyme."
      Tian X.-L. , Paul M.
      Biochem. Pharmacol.66:1037-1044(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TESTIS-SPECIFIC);TISSUE SPECIFICITY
      strain: Sprague-Dawley.
      tissue: Testis.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SOMATIC)
      tissue: Lung.
    5. 5.
      "Analysis of the angiotensin converting enzyme (Ace) cDNA sequence and mRNA level of expression in WAG and ISIAH rats."
      Tsetsarkin K.A. , Dymshits G.M. , Markel A.L. , Redina O.E.
      Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-1313 (ISOFORM SOMATIC);VARIANT LYS-207
      tissue: Kidney.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
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