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Index > Protein center > Epha4(Gene name) > Mouse
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  • Epha4 (Gene name),
  • Ephrin type-A receptor 4 (Protein name ),  EPHA4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Epha4(Sek;Sek1);
    Protein name:
    Ephrin type-A receptor 4;
    Alternative:
    Tyrosine-protein kinase receptor SEK-1;Tyrosine-protein kinase receptor MPK-3;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts (via PDZ motif) with SIPA1L1 (via PDZ domain); controls neuronal morphology through regulation of the RAP1 (RAP1A or RAP1B) and RAP2 (RAP2A, RAP2B or RAP2C) GTPases. Interacts with CDK5, CDK5R1 and NGEF; upon activation by EFNA1 induces NGEF phosphorylation by the kinase CDK5. Interacts with CHN1; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.
    Function:
    Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. Beside its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Cell projection axon Cell projection dendrite Cell junction synapse postsynaptic cell membrane postsynaptic density Early endosome Clustered upon activation and targeted to early endosome.
    Protein Attributes:
    Sequence length:
    986
    Sequence:
    50:
    MAGIFYFILF | SFLFGICDAV | TGSRVYPANE | VTLLDSRSVQ | GELGWIASPL | 
    100:
    EGGWEEVSIM | DEKNTPIRTY | QVCNVMEASQ | NNWLRTDWIT | REGAQRVYIE | 
    150:
    IKFTLRDCNS | LPGVMGTCKE | TFNLYYYESD | NDKERFIRES | QFGKIDTIAA | 
    200:
    DESFTQVDIG | DRIMKLNTEI | RDVGPLSKKG | FYLAFQDVGA | CIALVSVRVF | 
    250:
    YKKCPLTVRN | LAQFPDTITG | ADTSSLVEVR | GSCVNNSEEK | DVPKMYCGAD | 
    300:
    GEWLVPIGNC | LCNAGHEEQN | GECQACKIGY | YKALSTDASC | AKCPPHSYSV | 
    350:
    WEGATSCTCD | RGFFRADNDA | ASMPCTRPPS | APLNLISNVN | ETSVNLEWSS | 
    400:
    PQNTGGRQDI | SYNVVCKKCG | AGDPSKCRPC | GSGVHYTPQQ | NGLKTTRVSI | 
    450:
    TDLLAHTNYT | FEIWAVNGVS | KYNPSPDQSV | SVTVTTNQAA | PSSIALVQAK | 
    500:
    EVTRYSVALA | WLEPDRPNGV | ILEYEVKYYE | KDQNERSYRI | VRTAARNTDI | 
    550:
    KGLNPLTSYV | FHVRARTAAG | YGDFSEPLEV | TTNTVPSRII | GDGANSTVLL | 
    600:
    VSVSGSVVLV | VILIAAFVIS | RRRSKYSKAK | QEADEEKHLN | QGVRTYVDPF | 
    650:
    TYEDPNQAVR | EFAKEIDASC | IKIEKVIGVG | EFGEVCSGRL | KVPGKREICV | 
    700:
    AIKTLKAGYT | DKQRRDFLSE | ASIMGQFDHP | NIIHLEGVVT | KCKPVMIITE | 
    750:
    YMENGSLDAF | LRKNDGRFTV | IQLVGMLRGI | GSGMKYLSDM | SYVHRDLAAR | 
    800:
    NILVNSNLVC | KVSDFGMSRV | LEDDPEAAYT | TRGGKIPIRW | TAPEAIAYRK | 
    850:
    FTSASDVWSY | GIVMWEVMSY | GERPYWDMSN | QDVIKAIEEG | YRLPPPMDCP | 
    900:
    IALHQLMLDC | WQKERSDRPK | FGQIVNMLDK | LIRNPNSLKR | TGSESSRPNT | 
    950:
    ALLDPSSPEF | SAVVSVGDWL | QAIKMDRYKD | NFTAAGYTTL | EAVVHMSQDD | 
    986:
    LARIGITAIT | HQNKILSSVQ | AMRTQMQQMH | GRMVPV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ephrin type-A receptor 4
    Cat.:
    E0303m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Ephrin type-A receptor 4
    Cat.:
    E0303h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Ephrin type-A receptor 4
    Cat.:
    E0303c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Ephrin type-A receptor 4
    Cat.:
    U0303c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ephrin type-A receptor 4
    Cat.:
    U0303m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Ephrin type-A receptor 4
    Cat.:
    U0303h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse Ephrin type-A receptor 4
    Cat.:
    P0303Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Ephrin type-A receptor 4
    Polyclonal Antibody for Mouse Ephrin type-A receptor 4
    Cat.:
    P0303Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Ephrin type-A receptor 4
    Monoclonal Antibody for Mouse Ephrin type-A receptor 4
    Monoclonal Antibody for Mouse Ephrin type-A receptor 4
    Protein for Mouse Ephrin type-A receptor 4
    Protein for Mouse Ephrin type-A receptor 4
    Protein for Mouse Ephrin type-A receptor 4

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    Linearity
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    References
    1. 1.
      "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain."
      Gilardi-Hebenstreit P. , Nieto M.A. , Frain M. , Mattei M.-G. , Chestier A. , Wilkinson D.G. , Charnay P.
      Oncogene7:2499-2506(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
      strain: C57BL/6.
      tissue: Embryonic brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      strain: C57BL/6J.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      tissue: Limb.
    6. 6.
      "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn."
      Ellis C. , Kasmi F. , Ganju P. , Walls E. , Panayotou G. , Reith A.D.
      Oncogene12:1727-1736(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-596 AND TYR-602;INTERACTION WITH FYN
    7. 7.
      "EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract."
      Dottori M. , Hartley L. , Galea M. , Paxinos G. , Polizzotto M. , Kilpatrick T. , Bartlett P.F. , Murphy M. , Koentgen F. , Boyd A.W.
      Proc. Natl. Acad. Sci. U.S.A.95:13248-13253(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN AXON GUIDANCE
    8. 8.
      "EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin."
      Shamah S.M. , Lin M.Z. , Goldberg J.L. , Estrach S. , Sahin M. , Hu L. , Bazalakova M. , Neve R.L. , Corfas G. , Debant A. , Greenberg M.E.
      Cell105:233-244(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NGEF;MUTAGENESIS OF VAL-635
    9. 9.
      "Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord."
      Greferath U. , Canty A.J. , Messenger J. , Murphy M.
      Mech. Dev.119:S231-S238(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
    10. 10.
      "Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice."
      Goldshmit Y. , Galea M.P. , Wise G. , Bartlett P.F. , Turnley A.M.
      J. Neurosci.24:10064-10073(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN AXONAL REGENERATION
    11. 11.
      "EphA4 regulates central nervous system vascular formation."
      Goldshmit Y. , Galea M.P. , Bartlett P.F. , Turnley A.M.
      J. Comp. Neurol.497:864-875(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ANGIOGENESIS
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN THYMUS DEVELOPMENT
    13. 13.
      "Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling."
      Iwasato T. , Katoh H. , Nishimaru H. , Ishikawa Y. , Inoue H. , Saito Y.M. , Ando R. , Iwama M. , Takahashi R. , Negishi M. , Itohara S.
      Cell130:742-753(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RAC1 REGULATION;FUNCTION IN AXON GUIDANCE;INTERACTION WITH CHN1
    14. 14.
      "The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases."
      Richter M. , Murai K.K. , Bourgin C. , Pak D.T. , Pasquale E.B.
      J. Neurosci.27:14205-14215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEURON MORPHOLOGY;INTERACTION WITH SIPA1L1
    15. 15.
      "Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
      Fu W.Y. , Chen Y. , Sahin M. , Zhao X.S. , Shi L. , Bikoff J.B. , Lai K.O. , Yung W.H. , Fu A.K. , Greenberg M.E. , Ip N.Y.
      Nat. Neurosci.10:67-76(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DENDRITIC SPINE MORPHOGENESIS;TOPOLOGY;SUBCELLULAR LOCATION;INTERACTION WITH NGEF
    16. 16.
      "alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits."
      Beg A.A. , Sommer J.E. , Martin J.H. , Scheiffele P.
      Neuron55:768-778(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AXON GUIDANCE;INTERACTION WITH CHN1;MUTAGENESIS OF VAL-635
    17. 17.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-602;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    18. 18.
      "Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling."
      Gallarda B.W. , Bonanomi D. , Mueller D. , Brown A. , Alaynick W.A. , Andrews S.E. , Lemke G. , Pfaff S.L. , Marquardt T.
      Science320:233-236(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MOTOR AND SENSORY AXONS SEGREGATION
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