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Index > Protein center > Jak3(Gene name) > Mouse
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  • Jak3 (Gene name),
  • Tyrosine-protein kinase JAK3 (Protein name ),  JAK3_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Jak3;
    Protein name:
    Tyrosine-protein kinase JAK3;
    Alternative:
    Janus kinase 3(JAK-3);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with STAM2 and MYO18A. Interacts with SHB.
    Function:
    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
    Subcellular Location:
    Endomembrane system Peripheral membrane protein Cytoplasm
    Protein Attributes:
    Sequence length:
    1100
    Sequence:
    50:
    MAPPSEETPL | IPQRSCSLSS | SEAGALHVLL | PPRGPGPPQR | LSFSFGDYLA | 
    100:
    EDLCVRAAKA | CGILPVYHSL | FALATEDFSC | WFPPSHIFCI | EDVDTQVLVY | 
    150:
    RLRFYFPDWF | GLETCHRFGL | RKDLTSAILD | LHVLEHLFAQ | HRSDLVSGRL | 
    200:
    PVGLSMKEQG | EFLSLAVLDL | AQMAREQAQR | PGELLKTVSY | KACLPPSLRD | 
    250:
    VIQGQNFVTR | RRIRRTVVLA | LRRVVACQAD | RYALMAKYIL | DLERLHPAAT | 
    300:
    TETFRVGLPG | AQEEPGLLRV | AGDNGISWSS | GDQELFQTFC | DFPEIVDVSI | 
    350:
    KQAPRVGPAG | EHRLVTVTRM | DGHILEAEFP | GLPEALSFVA | LVDGYFRLIC | 
    400:
    DSRHYFCKEV | APPRLLEEEA | ELCHGPITLD | FAIHKLKAAG | SLPGTYILRR | 
    450:
    SPQDYDSFLL | TACVQTPLGP | DYKGCLIRQD | PSGAFSLVGL | SQPHRSLREL | 
    500:
    LAACWNSGLR | VDGAALNLTS | CCAPRPKEKS | NLIVVRRGCT | PAPAPGCSPS | 
    550:
    CCALTQLSFH | TIPTDSLEWH | ENLGHGSFTK | IFRGRRREVV | DGETHDSEVL | 
    600:
    LKVMDSRHRN | CMESFLEAAS | LMSQVSYPHL | VLLHGVCMAG | DSIMVQEFVY | 
    650:
    LGAIDMYLRK | RGHLVSASWK | LQVTKQLAYA | LNYLEDKGLP | HGNVSARKVL | 
    700:
    LAREGGDGNP | PFIKLSDPGV | SPTVLSLEML | TDRIPWVAPE | CLQEAQTLCL | 
    750:
    EADKWGFGAT | TWEVFSGGPA | HITSLEPAKK | LKFYEDQGQL | PALKWTELAG | 
    800:
    LITQCMAYDP | GRRPSFRAIL | RDLNGLITSD | YELLSDPTPG | IPSPRDELCG | 
    850:
    GAQLYACQDP | AIFEERHLKY | ISLLGKGNFG | SVELCRYDPL | GDNTGPLVAV | 
    900:
    KQLQHSGPDQ | QRDFQREIQI | LKALHSDFIV | KYRGVSYGPG | RQSLRLVMEY | 
    950:
    LPSGCLRDFL | QRHRARLHTD | RLLLFAWQIC | KGMEYLGARR | CVHRDLAARN | 
    1000:
    ILVESEAHVK | IADFGLAKLL | PLGKDYYVVR | EPGQSPIFWY | APESLSDNIF | 
    1050:
    SRQSDVWSFG | VVLYELFTYC | DKSCSPSAEF | LRMMGPEREG | PPLCRLLELL | 
    1100:
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    KEGG:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    E0425r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    E0425h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    E0425m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    U0425r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    U0425m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    U0425h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    P0425Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    P0425Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tyrosine-protein kinase JAK3
    Cat.:
    P0425Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Tyrosine-protein kinase JAK3
    Monoclonal Antibody for Mouse Tyrosine-protein kinase JAK3
    Monoclonal Antibody for Mouse Tyrosine-protein kinase JAK3
    Protein for Mouse Tyrosine-protein kinase JAK3
    Protein for Mouse Tyrosine-protein kinase JAK3
    Protein for Mouse Tyrosine-protein kinase JAK3

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    s
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of JAK3 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of JAK3 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells."
      Rane S.G. , Reddy E.P.
      Oncogene9:2415-2423(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells."
      Gurniak C.B. , Berg L.J.
      Blood87:3151-3160(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;MUTAGENESIS OF LEU-853
      strain: BALB/C X 129.
      tissue: Thymus.
    3. 3.
      "Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells."
      Witthuhn B.A. , Silvennoinen O. , Miura O. , Lai K.S. , Cwik C. , Liu E.T. , Ihle J.N.
      Nature370:153-157(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: BALB/c.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Heart.
      tissue: Spleen.
      tissue: Thymus.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: FVB/N.
      tissue: Mammary tumor.
    6. 6.
      "Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3."
      Thomis D.C. , Gurniak C.B. , Tivol E. , Sharpe A.H. , Berg L.J.
      Science270:794-797(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    8. 8.
      "Peripheral expression of Jak3 is required to maintain T lymphocyte function."
      Thomis D.C. , Berg L.J.
      J. Exp. Med.185:197-206(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "T cell development and activation in Jak3-deficient mice."
      Baird A.M. , Thomis D.C. , Berg L.J.
      J. Leukoc. Biol.63:669-677(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    10. 10.
      "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival."
      Ji H. , Zhai Q. , Zhu J. , Yan M. , Sun L. , Liu X. , Zheng Z.
      Biochem. Biophys. Res. Commun.270:267-271(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MYO18A
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