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Index > Protein center > LRP2(Gene name) > Human
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  • LRP2 (Gene name),
  • Low-density lipoprotein receptor-related protein 2 (Protein name ),  LRP2_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    LRP2;
    Protein name:
    Low-density lipoprotein receptor-related protein 2(LRP-2);
    Alternative:
    Megalin;Glycoprotein 330(gp330);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.
    Function:
    Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Membrane coated pit
    Protein Attributes:
    Sequence length:
    4655
    Sequence:
    50:
    MDRGPAAVAC | TLLLALVACL | APASGQECDS | AHFRCGSGHC | IPADWRCDGT | 
    100:
    KDCSDDADEI | GCAVVTCQQG | YFKCQSEGQC | IPNSWVCDQD | QDCDDGSDER | 
    150:
    QDCSQSTCSS | HQITCSNGQC | IPSEYRCDHV | RDCPDGADEN | DCQYPTCEQL | 
    200:
    TCDNGACYNT | SQKCDWKVDC | RDSSDEINCT | EICLHNEFSC | GNGECIPRAY | 
    250:
    VCDHDNDCQD | GSDEHACNYP | TCGGYQFTCP | SGRCIYQNWV | CDGEDDCKDN | 
    300:
    GDEDGCESGP | HDVHKCSPRE | WSCPESGRCI | SIYKVCDGIL | DCPGREDENN | 
    350:
    TSTGKYCSMT | LCSALNCQYQ | CHETPYGGAC | FCPPGYIINH | NDSRTCVEFD | 
    400:
    DCQIWGICDQ | KCESRPGRHL | CHCEEGYILE | RGQYCKANDS | FGEASIIFSN | 
    450:
    GRDLLIGDIH | GRSFRILVES | QNRGVAVGVA | FHYHLQRVFW | TDTVQNKVFS | 
    500:
    VDINGLNIQE | VLNVSVETPE | NLAVDWVNNK | IYLVETKVNR | IDMVNLDGSY | 
    550:
    RVTLITENLG | HPRGIAVDPT | VGYLFFSDWE | SLSGEPKLER | AFMDGSNRKD | 
    600:
    LVKTKLGWPA | GVTLDMISKR | VYWVDSRFDY | IETVTYDGIQ | RKTVVHGGSL | 
    650:
    IPHPFGVSLF | EGQVFFTDWT | KMAVLKANKF | TETNPQVYYQ | ASLRPYGVTV | 
    700:
    YHSLRQPYAT | NPCKDNNGGC | EQVCVLSHRT | DNDGLGFRCK | CTFGFQLDTD | 
    750:
    ERHCIAVQNF | LIFSSQVAIR | GIPFTLSTQE | DVMVPVSGNP | SFFVGIDFDA | 
    800:
    QDSTIFFSDM | SKHMIFKQKI | DGTGREILAA | NRVENVESLA | FDWISKNLYW | 
    850:
    TDSHYKSISV | MRLADKTRRT | VVQYLNNPRS | VVVHPFAGYL | FFTDWFRPAK | 
    900:
    IMRAWSDGSH | LLPVINTTLG | WPNGLAIDWA | ASRLYWVDAY | FDKIEHSTFD | 
    950:
    GLDRRRLGHI | EQMTHPFGLA | IFGEHLFFTD | WRLGAIIRVR | KADGGEMTVI | 
    1000:
    RSGIAYILHL | KSYDVNIQTG | SNACNQPTHP | NGDCSHFCFP | VPNFQRVCGC | 
    1050:
    PYGMRLASNH | LTCEGDPTNE | PPTEQCGLFS | FPCKNGRCVP | NYYLCDGVDD | 
    1100:
    CHDNSDEQLC | GTLNNTCSSS | AFTCGHGECI | PAHWRCDKRN | DCVDGSDEHN | 
    1150:
    CPTHAPASCL | DTQYTCDNHQ | CISKNWVCDT | DNDCGDGSDE | KNCNSTETCQ | 
    1200:
    PSQFNCPNHR | CIDLSFVCDG | DKDCVDGSDE | VGCVLNCTAS | QFKCASGDKC | 
    1250:
    IGVTNRCDGV | FDCSDNSDEA | GCPTRPPGMC | HSDEFQCQED | GICIPNFWEC | 
    1300:
    DGHPDCLYGS | DEHNACVPKT | CPSSYFHCDN | GNCIHRAWLC | DRDNDCGDMS | 
    1350:
    DEKDCPTQPF | RCPSWQWQCL | GHNICVNLSV | VCDGIFDCPN | GTDESPLCNG | 
    1400:
    NSCSDFNGGC | THECVQEPFG | AKCLCPLGFL | LANDSKTCED | IDECDILGSC | 
    1450:
    SQHCYNMRGS | FRCSCDTGYM | LESDGRTCKV | TASESLLLLV | ASQNKIIADS | 
    1500:
    VTSQVHNIYS | LVENGSYIVA | VDFDSISGRI | FWSDATQGKT | WSAFQNGTDR | 
    1550:
    RVVFDSSIIL | TETIAIDWVG | RNLYWTDYAL | ETIEVSKIDG | SHRTVLISKN | 
    1600:
    LTNPRGLALD | PRMNEHLLFW | SDWGHHPRIE | RASMDGSMRT | VIVQDKIFWP | 
    1650:
    CGLTIDYPNR | LLYFMDSYLD | YMDFCDYNGH | HRRQVIASDL | IIRHPYALTL | 
    1700:
    FEDSVYWTDR | ATRRVMRANK | WHGGNQSVVM | YNIQWPLGIV | AVHPSKQPNS | 
    1750:
    VNPCAFSRCS | HLCLLSSQGP | HFYSCVCPSG | WSLSPDLLNC | LRDDQPFLIT | 
    1800:
    VRQHIIFGIS | LNPEVKSNDA | MVPIAGIQNG | LDVEFDDAEQ | YIYWVENPGE | 
    1850:
    IHRVKTDGTN | RTVFASISMV | GPSMNLALDW | ISRNLYSTNP | RTQSIEVLTL | 
    1900:
    HGDIRYRKTL | IANDGTALGV | GFPIGITVDP | ARGKLYWSDQ | GTDSGVPAKI | 
    1950:
    ASANMDGTSV | KTLFTGNLEH | LECVTLDIEE | QKLYWAVTGR | GVIERGNVDG | 
    2000:
    TDRMILVHQL | SHPWGIAVHD | SFLYYTDEQY | EVIERVDKAT | GANKIVLRDN | 
    2050:
    VPNLRGLQVY | HRRNAAESSN | GCSNNMNACQ | QICLPVPGGL | FSCACATGFK | 
    2100:
    LNPDNRSCSP | YNSFIVVSML | SAIRGFSLEL | SDHSETMVPV | AGQGRNALHV | 
    2150:
    DVDVSSGFIY | WCDFSSSVAS | DNAIRRIKPD | GSSLMNIVTH | GIGENGVRGI | 
    2200:
    AVDWVAGNLY | FTNAFVSETL | IEVLRINTTY | RRVLLKVTVD | MPRHIVVDPK | 
    2250:
    NRYLFWADYG | QRPKIERSFL | DCTNRTVLVS | EGIVTPRGLA | VDRSDGYVYW | 
    2300:
    VDDSLDIIAR | IRINGENSEV | IRYGSRYPTP | YGITVFENSI | IWVDRNLKKI | 
    2350:
    FQASKEPENT | EPPTVIRDNI | NWLRDVTIFD | KQVQPRSPAE | VNNNPCLENN | 
    2400:
    GGCSHLCFAL | PGLHTPKCDC | AFGTLQSDGK | NCAISTENFL | IFALSNSLRS | 
    2450:
    LHLDPENHSP | PFQTINVERT | VMSLDYDSVS | DRIYFTQNLA | SGVGQISYAT | 
    2500:
    LSSGIHTPTV | IASGIGTADG | IAFDWITRRI | YYSDYLNQMI | NSMAEDGSNR | 
    2550:
    TVIARVPKPR | AIVLDPCQGY | LYWADWDTHA | KIERATLGGN | FRVPIVNSSL | 
    2600:
    VMPSGLTLDY | EEDLLYWVDA | SLQRIERSTL | TGVDREVIVN | AAVHAFGLTL | 
    2650:
    YGQYIYWTDL | YTQRIYRANK | YDGSGQIAMT | TNLLSQPRGI | NTVVKNQKQQ | 
    2700:
    CNNPCEQFNG | GCSHICAPGP | NGAECQCPHE | GNWYLANNRK | HCIVDNGERC | 
    2750:
    GASSFTCSNG | RCISEEWKCD | NDNDCGDGSD | EMESVCALHT | CSPTAFTCAN | 
    2800:
    GRCVQYSYRC | DYYNDCGDGS | DEAGCLFRDC | NATTEFMCNN | RRCIPREFIC | 
    2850:
    NGVDNCHDNN | TSDEKNCPDR | TCQSGYTKCH | NSNICIPRVY | LCDGDNDCGD | 
    2900:
    NSDENPTYCT | THTCSSSEFQ | CASGRCIPQH | WYCDQETDCF | DASDEPASCG | 
    2950:
    HSERTCLADE | FKCDGGRCIP | SEWICDGDND | CGDMSDEDKR | HQCQNQNCSD | 
    3000:
    SEFLCVNDRP | PDRRCIPQSW | VCDGDVDCTD | GYDENQNCTR | RTCSENEFTC | 
    3050:
    GYGLCIPKIF | RCDRHNDCGD | YSDERGCLYQ | TCQQNQFTCQ | NGRCISKTFV | 
    3100:
    CDEDNDCGDG | SDELMHLCHT | PEPTCPPHEF | KCDNGRCIEM | MKLCNHLDDC | 
    3150:
    LDNSDEKGCG | INECHDPSIS | GCDHNCTDTL | TSFYCSCRPG | YKLMSDKRTC | 
    3200:
    VDIDECTEMP | FVCSQKCENV | IGSYICKCAP | GYLREPDGKT | CRQNSNIEPY | 
    3250:
    LIFSNRYYLR | NLTIDGYFYS | LILEGLDNVV | ALDFDRVEKR | LYWIDTQRQV | 
    3300:
    IERMFLNKTN | KETIINHRLP | AAESLAVDWV | SRKLYWLDAR | LDGLFVSDLN | 
    3350:
    GGHRRMLAQH | CVDANNTFCF | DNPRGLALHP | QYGYLYWADW | GHRAYIGRVG | 
    3400:
    MDGTNKSVII | STKLEWPNGI | TIDYTNDLLY | WADAHLGYIE | YSDLEGHHRH | 
    3450:
    TVYDGALPHP | FAITIFEDTI | YWTDWNTRTV | EKGNKYDGSN | RQTLVNTTHR | 
    3500:
    PFDIHVYHPY | RQPIVSNPCG | TNNGGCSHLC | LIKPGGKGFT | CECPDDFRTL | 
    3550:
    QLSGSTYCMP | MCSSTQFLCA | NNEKCIPIWW | KCDGQKDCSD | GSDELALCPQ | 
    3600:
    RFCRLGQFQC | SDGNCTSPQT | LCNAHQNCPD | GSDEDRLLCE | NHHCDSNEWQ | 
    3650:
    CANKRCIPES | WQCDTFNDCE | DNSDEDSSHC | ASRTCRPGQF | RCANGRCIPQ | 
    3700:
    AWKCDVDNDC | GDHSDEPIEE | CMSSAHLCDN | FTEFSCKTNY | RCIPKWAVCN | 
    3750:
    GVDDCRDNSD | EQGCEERTCH | PVGDFRCKNH | HCIPLRWQCD | GQNDCGDNSD | 
    3800:
    EENCAPRECT | ESEFRCVNQQ | CIPSRWICDH | YNDCGDNSDE | RDCEMRTCHP | 
    3850:
    EYFQCTSGHC | VHSELKCDGS | ADCLDASDEA | DCPTRFPDGA | YCQATMFECK | 
    3900:
    NHVCIPPYWK | CDGDDDCGDG | SDEELHLCLD | VPCNSPNRFR | CDNNRCIYSH | 
    3950:
    EVCNGVDDCG | DGTDETEEHC | RKPTPKPCTE | YEYKCGNGHC | IPHDNVCDDA | 
    4000:
    DDCGDWSDEL | GCNKGKERTC | AENICEQNCT | QLNEGGFICS | CTAGFETNVF | 
    4050:
    DRTSCLDINE | CEQFGTCPQH | CRNTKGSYEC | VCADGFTSMS | DRPGKRCAAE | 
    4100:
    GSSPLLLLPD | NVRIRKYNLS | SERFSEYLQD | EEYIQAVDYD | WDPKDIGLSV | 
    4150:
    VYYTVRGEGS | RFGAIKRAYI | PNFESGRNNL | VQEVDLKLKY | VMQPDGIAVD | 
    4200:
    WVGRHIYWSD | VKNKRIEVAK | LDGRYRKWLI | STDLDQPAAI | AVNPKLGLMF | 
    4250:
    WTDWGKEPKI | ESAWMNGEDR | NILVFEDLGW | PTGLSIDYLN | NDRIYWSDFK | 
    4300:
    EDVIETIKYD | GTDRRVIAKE | AMNPYSLDIF | EDQLYWISKE | KGEVWKQNKF | 
    4350:
    GQGKKEKTLV | VNPWLTQVRI | FHQLRYNKSV | PNLCKQICSH | LCLLRPGGYS | 
    4400:
    CACPQGSSFI | EGSTTECDAA | IELPINLPPP | CRCMHGGNCY | FDETDLPKCK | 
    4450:
    CPSGYTGKYC | EMAFSKGISP | GTTAVAVLLT | ILLIVVIGAL | AIAGFFHYRR | 
    4500:
    TGSLLPALPK | LPSLSSLVKP | SENGNGVTFR | SGADLNMDIG | VSGFGPETAI | 
    4550:
    DRSMAMSEDF | VMEMGKQPII | FENPMYSARD | SAVKVVQPIQ | VTVSENVDNK | 
    4600:
    NYGSPINPSE | IVPETNPTSP | AADGTQVTKW | NLFKRKSKQT | TNFENPIYAQ | 
    4650:
    MENEQKESVA | ATPPPSPSLP | AKPKPPSRRD | PTPTYSATED | TFKDTANLVK | 
    4655:
    EDSEV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    Pfam:
    KEGG:
    MIM:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human LRP-2
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    E0001r
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    ELISA Kit for Human LRP-2
    Cat.:
    E0001m
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    Packing:
    96T
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    ELISA Kit for Human LRP-2
    Cat.:
    E0001h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human LRP-2
    Cat.:
    U0001h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human LRP-2
    Cat.:
    U0001m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human LRP-2
    Cat.:
    U0001r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human LRP-2
    Cat.:
    P0001Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LRP-2
    Cat.:
    P0001Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LRP-2
    Cat.:
    P0001Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human LRP-2
    Monoclonal Antibody for Human LRP-2
    Monoclonal Antibody for Human LRP-2
    Protein for Human LRP-2
    Protein for Human LRP-2
    Protein for Human LRP-2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties."
      Hjaelm G. , Murray E. , Crumley G. , Harazim W. , Lundgren S. , Onyango I. , Ek B. , Larsson M. , Juhlin C. , Hellman P. , Davis H. , Aekerstroem G. , Rask L. , Morse B.
      Eur. J. Biochem.239:132-137(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-83
      tissue: Kidney.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)."
      Korenberg J.R. , Argraves K.M. , Chen X.N. , Tran H. , Strickland D.K. , Argraves W.S.
      Genomics22:88-93(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2705-4453;VARIANTS GLU-4094 AND LEU-4210
      tissue: Kidney.
    4. 4.
      "A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily."
      Lundgren S. , Hjaelm G. , Hellman P. , Ek B. , Juhlin C. , Rastad J. , Klareskog L. , Aakerstroem G. , Rask L.
      Exp. Cell Res.212:344-350(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4139-4406
    5. 5.
      "Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin."
      Kounnas M.Z. , Loukinova E.B. , Stefansson S. , Harmony J.A.K. , Brewer B.H. , Strickland D.K. , Argraves W.S.
      J. Biol. Chem.270:13070-13075(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLU
    6. 6.
      "Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin."
      Oleinikov A.V. , Zhao J. , Makker S.P.
      Biochem. J.347:613-621(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
    7. 7.
      "Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule."
      Petersen H.H. , Hilpert J. , Militz D. , Zandler V. , Jacobsen C. , Roebroek A.J.M. , Willnow T.E.
      J. Cell Sci.116:453-461(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP2BP
    8. 8.
      "The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin."
      Gallagher H. , Oleinikov A.V. , Fenske C. , Newman D.J.
      Biochimie86:179-182(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-4272
    10. 10.
      "Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes."
      Kantarci S. , Al-Gazali L. , Hill R.S. , Donnai D. , Black G.C.M. , Bieth E. , Chassaing N. , Lacombe D. , Devriendt K. , Teebi A. , Loscertales M. , Robson C. , Liu T. , MacLaughlin D.T. , Noonan K.M. , Russell M.K. , Walsh C.A. , Donahoe P.K. , more...
      Nat. Genet.39:957-959(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DBS HIS-2522
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-103
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