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Index > Protein center > MMP13(Gene name) > Human
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  • MMP13 (Gene name),
  • Collagenase 3 (Protein name ),  MMP13_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    MMP13;
    Protein name:
    Collagenase 3;
    Alternative:
    Matrix metalloproteinase-13(MMP-13);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    471
    Sequence:
    50:
    MHPGVLAAFL | FLSWTHCRAL | PLPSGGDEDD | LSEEDLQFAE | RYLRSYYHPT | 
    100:
    NLAGILKENA | ASSMTERLRE | MQSFFGLEVT | GKLDDNTLDV | MKKPRCGVPD | 
    150:
    VGEYNVFPRT | LKWSKMNLTY | RIVNYTPDMT | HSEVEKAFKK | AFKVWSDVTP | 
    200:
    LNFTRLHDGI | ADIMISFGIK | EHGDFYPFDG | PSGLLAHAFP | PGPNYGGDAH | 
    250:
    FDDDETWTSS | SKGYNLFLVA | AHEFGHSLGL | DHSKDPGALM | FPIYTYTGKS | 
    300:
    HFMLPDDDVQ | GIQSLYGPGD | EDPNPKHPKT | PDKCDPSLSL | DAITSLRGET | 
    350:
    MIFKDRFFWR | LHPQQVDAEL | FLTKSFWPEL | PNRIDAAYEH | PSHDLIFIFR | 
    400:
    GRKFWALNGY | DILEGYPKKI | SELGLPKEVK | KISAAVHFED | TGKTLLFSGN | 
    450:
    QVWRYDDTNH | IMDKDYPRLI | EEDFPGIGDK | VDAVYEKNGY | IYFFNGPIQF | 
    471:
    EYSIWSNRIV | RVMPANSILW | C
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    MIM:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Collagenase 3
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    ELISA Kit for Human Collagenase 3
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    ELISA Kit for Human Collagenase 3
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    ELISA Kit for Human Collagenase 3
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    ELISA Kit for Human Collagenase 3
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    CLIA Kit for Human Collagenase 3
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    CLIA Kit for Human Collagenase 3
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    CLIA Kit for Human Collagenase 3
    Cat.:
    U0099h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Collagenase 3
    Cat.:
    U0099m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human Collagenase 3
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    U0099b
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    Polyclonal Antibody for Human Collagenase 3
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    P0099Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Collagenase 3
    Polyclonal Antibody for Human Collagenase 3
    Polyclonal Antibody for Human Collagenase 3
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    P0099Rb-r
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    Packing:
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    Polyclonal Antibody for Human Collagenase 3
    Cat.:
    P0099Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Collagenase 3
    Monoclonal Antibody for Human Collagenase 3
    Monoclonal Antibody for Human Collagenase 3
    Monoclonal Antibody for Human Collagenase 3
    Monoclonal Antibody for Human Collagenase 3
    Protein for Human Collagenase 3
    Protein for Human Collagenase 3
    Protein for Human Collagenase 3
    Protein for Human Collagenase 3
    Protein for Human Collagenase 3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas."
      Freije J.M.P. , Diez-Itza I. , Balbin M. , Sanchez L.M. , Blasco R. , Tolivia J. , Lopez-Otin C.
      J. Biol. Chem.269:16766-16773(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;FUNCTION;TISSUE SPECIFICITY
      tissue: Mammary carcinoma.
    2. 2.
      "A matrix metalloproteinase gene expressed in human T lymphocytes is identical with collagenase 3 from breast carcinomas."
      Willmroth F. , Peter H.H. , Conca W.
      Immunobiology198:375-384(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Esophagus.
      tissue: Synovium.
    4. 4.
      NIEHS SNPs program
      Submitted (2004-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-390
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    6. 6.
      "Biochemical characterization of human collagenase-3."
      Knaeuper V. , Lopez-Otin C. , Smith B. , Knight G. , Murphy G.
      J. Biol. Chem.271:1544-1550(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-27 AND 104-118;PROPEPTIDE;AUTOCATALYTIC PROCESSING;CATALYTIC ACTIVITY;FUNCTION;GLYCOSYLATION AT ASN-117;SUBCELLULAR LOCATION;ENZYME REGULATION;INTERACTION WITH TIMP1; TIMP2 AND TIMP3
    7. 7.
      "Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme."
      Knaeuper V. , Will H. , Lopez-Otin C. , Smith B. , Atkinson S.J. , Stanton H. , Hembry R.M. , Murphy G.
      J. Biol. Chem.271:17124-17131(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;PROPEPTIDE;FUNCTION;CATALYTIC ACTIVITY
    8. 8.
      "Degradation of cartilage aggrecan by collagenase-3 (MMP-13)."
      Fosang A.J. , Last K. , Knaeuper V. , Murphy G. , Neame P.J.
      FEBS Lett.380:17-20(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes."
      Borden P. , Solymar D. , Sucharczuk A. , Lindman B. , Cannon P. , Heller R.A.
      J. Biol. Chem.271:23577-23581(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;TISSUE SPECIFICITY
    10. 10.
      "Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development."
      Johansson N. , Saarialho-Kere U. , Airola K. , Herva R. , Nissinen L. , Westermarck J. , Vuorio E. , Heino J. , Kaehaeri V.M.
      Dev. Dyn.208:387-397(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION BY TGFB1
    11. 11.
      "The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction."
      Knaeuper V. , Cowell S. , Smith B. , Lopez-Otin C. , O'Shea M. , Morris H. , Zardi L. , Murphy G.
      J. Biol. Chem.272:7608-7616(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;CATALYTIC ACTIVITY;AUTOCATALYTIC PROCESSING;FUNCTION;INTERACTION WITH TIMP1; TIMP2 AND TIMP3;ENZYME REGULATION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-366
    13. 13.
      "The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain."
      Gomis-Rueth F.-X. , Gohlke U. , Betz M. , Knaeuper V. , Murphy G. , Lopez-Otin C. , Bode W.
      J. Mol. Biol.264:556-566(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 265-471 IN COMPLEX WITH CALCIUM;DISULFIDE BOND
    14. 14.
      "Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors."
      Lovejoy B. , Welch A.R. , Carr S. , Luong C. , Broka C. , Hendricks R.T. , Campbell J.A. , Walker K.A. , Martin R. , Van Wart H. , Browner M.F.
      Nat. Struct. Biol.6:217-221(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 104-271 IN COMPLEXES WITH SYNTHETIC INHIBITORS; CALCIUM AND ZINC;PROPEPTIDE;AUTOCATALYTIC PROCESSING
    15. 15.
      "Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1."
      Zhang X. , Gonnella N.C. , Koehn J. , Pathak N. , Ganu V. , Melton R. , Parker D. , Hu S.I. , Nam K.Y.
      J. Mol. Biol.301:513-524(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC
    16. 16.
      "High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor."
      Moy F.J. , Chanda P.K. , Chen J.M. , Cosmi S. , Edris W. , Levin J.I. , Powers R.
      J. Mol. Biol.302:671-689(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 104-268 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 104-271 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY
    19. 19.
      "Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects."
      Johnson A.R. , Pavlovsky A.G. , Ortwine D.F. , Prior F. , Man C.F. , Bornemeier D.A. , Banotai C.A. , Mueller W.T. , McConnell P. , Yan C. , Baragi V. , Lesch C. , Roark W.H. , Wilson M. , Datta K. , Guzman R. , Han H.K. , Dyer R.D.
      J. Biol. Chem.282:27781-27791(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 104-270 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;FUNCTION IN CARTILAGE DEGRADATION
    20. 20.
      "Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2."
      Maskos K. , Lang R. , Tschesche H. , Bode W.
      J. Mol. Biol.366:1222-1231(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 104-268 IN COMPLEX WITH TIMP2; CALCIUM AND ZINC;INTERACTION WITH TIMP2
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR;FUNCTION
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 104-270 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR
    23. 23.
      "Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease."
      Becker D.P. , Barta T.E. , Bedell L.J. , Boehm T.L. , Bond B.R. , Carroll J. , Carron C.P. , Decrescenzo G.A. , Easton A.M. , Freskos J.N. , Funckes-Shippy C.L. , Heron M. , Hockerman S. , Howard C.P. , Kiefer J.R. , Li M.H. , Mathis K.J. , McDonald J.J. , more...
      J. Med. Chem.53:6653-6680(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 104-267 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR;FUNCTION
    24. 24.
      "Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins."
      Devel L. , Beau F. , Amoura M. , Vera L. , Cassar-Lajeunesse E. , Garcia S. , Czarny B. , Stura E.A. , Dive V.
      J. Biol. Chem.287:26647-26656(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.43 ANGSTROMS) OF 104-272 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) OF 103-274 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;FUNCTION
    26. 26.
      "Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain."
      Stura E.A. , Visse R. , Cuniasse P. , Dive V. , Nagase H.
      FASEB J.27:4395-4405(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 104-471 OF MUTANT ALA-223 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;DISULFIDE BOND;MUTAGENESIS OF GLU-223;ACTIVE SITE;SUBUNIT
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SEMD-MO SER-75;CHARACTERIZATION OF VARIANT SEMD-MO SER-75;FUNCTION IN BONE DEVELOPMENT
    28. 28.
      "Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia."
      Lausch E. , Keppler R. , Hilbert K. , Cormier-Daire V. , Nikkel S. , Nishimura G. , Unger S. , Spranger J. , Superti-Furga A. , Zabel B.
      Am. J. Hum. Genet.85:168-178(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MANDP1 SER-74; THR-91 AND ASN-232;FUNCTION IN BONE DEVELOPMENT
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