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Index > Protein center > Nr1h2(Gene name) > Mouse
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  • Nr1h2 (Gene name),
  • Oxysterols receptor LXR-beta (Protein name ),  NR1H2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Nr1h2(Lxrb;Rip15;Unr;Unr2);
    Protein name:
    Oxysterols receptor LXR-beta;
    Alternative:
    Nuclear receptor subfamily 1 group H member 2;Liver X receptor beta;Ubiquitously-expressed nuclear receptor;Retinoid X receptor-interacting protein No.15;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms a heterodimer with RXR.
    Function:
    Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    446
    Sequence:
    50:
    MSSPTSSLDT | PVPGNGSPQP | STSATSPTIK | EEGQETDPPP | GSEGSSSAYI | 
    100:
    VVILEPEDEP | ERKRKKGPAP | KMLGHELCRV | CGDKASGFHY | NVLSCEGCKG | 
    150:
    FFRRSVVHGG | AGRYACRGSG | TCQMDAFMRR | KCQLCRLRKC | KEAGMREQCV | 
    200:
    LSEEQIRKKR | IQKQQQQQPP | PPSEPAASSS | GRPAASPGTS | EASSQGSGEG | 
    250:
    EGIQLTAAQE | LMIQQLVAAQ | LQCNKRSFSD | QPKVTPWPLG | ADPQSRDARQ | 
    300:
    QRFAHFTELA | IISVQEIVDF | AKQVPGFLQL | GREDQIALLK | ASTIEIMLLE | 
    350:
    TARRYNHETE | CITFLKDFTY | SKDDFHRAGL | QVEFINPIFE | FSRAMRRLGL | 
    400:
    DDAEYALLIA | INIFSADRPN | VQEPSRVEAL | QQPYVEALLS | YTRIKRPQDQ | 
    446:
    LRFPRMLMKL | VSLRTLSSVH | SEQVFALRLQ | DKKLPPLLSE | IWDVHE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    E0212h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    E0212r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    E0212m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    E0212b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    U0212h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    U0212m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    U0212b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Oxysterols receptor LXR-beta
    Cat.:
    U0212r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Cat.:
    P0212Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Cat.:
    P0212Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Cat.:
    P0212Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Monoclonal Antibody for Mouse Oxysterols receptor LXR-beta
    Protein for Mouse Oxysterols receptor LXR-beta
    Protein for Mouse Oxysterols receptor LXR-beta
    Protein for Mouse Oxysterols receptor LXR-beta
    Protein for Mouse Oxysterols receptor LXR-beta

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    References
    1. 1.
      "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors."
      Seol W. , Choi H.S. , Moore D.D.
      Mol. Endocrinol.9:72-85(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta."
      Alberti S. , Steffensen K.R. , Gustafsson J.-A.
      Gene243:93-103(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/SvJ.
      tissue: Liver.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      "Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3)."
      Wada T. , Kang H.S. , Angers M. , Gong H. , Bhatia S. , Khadem S. , Ren S. , Ellis E. , Strom S.C. , Jetten A.M. , Xie W.
      Mol. Pharmacol.73:891-899(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN METABOLISM REGULATION
    5. 5.
      "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor."
      Zelcer N. , Hong C. , Boyadjian R. , Tontonoz P.
      Science325:100-104(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2."
      Hong C. , Duit S. , Jalonen P. , Out R. , Scheer L. , Sorrentino V. , Boyadjian R. , Rodenburg K.W. , Foley E. , Korhonen L. , Lindholm D. , Nimpf J. , van Berkel T.J. , Tontonoz P. , Zelcer N.
      J. Biol. Chem.285:19720-19726(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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