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Index > Protein center > Kitlg(Gene name) > Mouse
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  • Kitlg (Gene name),
  • Kit ligand (Protein name ),  SCF_MOUSE from NCBI database.
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  • Gene name:
    Kitlg(Kitl;Mgf;Sl;Slf);
    Protein name:
    Kit ligand;
    Alternative:
    Mast cell growth factor(MGF);Hematopoietic growth factor KL;Stem cell factor(SCF);Steel factor;c-Kit ligand;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.
    Function:
    Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
    Subcellular Location:
    Soluble KIT ligand Secreted
    Protein Attributes:
    Sequence length:
    273
    Sequence:
    50:
    MKKTQTWIIT | CIYLQLLLFN | PLVKTKEICG | NPVTDNVKDI | TKLVANLPND | 
    100:
    YMITLNYVAG | MDVLPSHCWL | RDMVIQLSLS | LTTLLDKFSN | ISEGLSNYSI | 
    150:
    IDKLGKIVDD | LVLCMEENAP | KNIKESPKRP | ETRSFTPEEF | FSIFNRSIDA | 
    200:
    FKDFMVASDT | SDCVLSSTLG | PEKDSRVSVT | KPFMLPPVAA | SSLRNDSSSS | 
    250:
    NRKAAKAPED | SGLQWTAMAL | PALISLVIGF | AFGALYWKKK | QSSLTRAVEN | 
    273:
    IQINEEDNEI | SMLQQKEREF | QEV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Kit ligand
    Cat.:
    E0120r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Kit ligand
    Cat.:
    E0120h
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    Packing:
    96T
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    ELISA Kit for Mouse Kit ligand
    Cat.:
    E0120m
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    96T
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    ELISA Kit for Mouse Kit ligand
    Cat.:
    E0120b
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    96T
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    ELISA Kit for Mouse Kit ligand
    Cat.:
    E0120c
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    Packing:
    96T
    ELISA Kit for Mouse Kit ligand
    Cat.:
    E0120d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse Kit ligand
    Cat.:
    E0120p
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Kit ligand
    Cat.:
    U0120p
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Kit ligand
    Cat.:
    U0120c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Kit ligand
    Cat.:
    U0120d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Kit ligand
    Cat.:
    U0120r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse Kit ligand
    Cat.:
    U0120h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Kit ligand
    Cat.:
    U0120b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Mouse Kit ligand
    Cat.:
    U0120m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Mouse Kit ligand
    Cat.:
    P0120Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Kit ligand
    Cat.:
    P0120Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Kit ligand
    Polyclonal Antibody for Mouse Kit ligand
    Polyclonal Antibody for Mouse Kit ligand
    Cat.:
    P0120Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Kit ligand
    Polyclonal Antibody for Mouse Kit ligand
    Monoclonal Antibody for Mouse Kit ligand
    Monoclonal Antibody for Mouse Kit ligand
    Monoclonal Antibody for Mouse Kit ligand
    Monoclonal Antibody for Mouse Kit ligand
    Monoclonal Antibody for Mouse Kit ligand
    Monoclonal Antibody for Mouse Kit ligand
    Monoclonal Antibody for Mouse Kit ligand
    Protein for Mouse Kit ligand
    Protein for Mouse Kit ligand
    Protein for Mouse Kit ligand
    Protein for Mouse Kit ligand
    Protein for Mouse Kit ligand
    Protein for Mouse Kit ligand
    Protein for Mouse Kit ligand

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms."
      Anderson D.M. , Lyman S.D. , Baird A. , Wignall J.M. , Eisenman J. , Rauch C. , March C.J. , Boswell H.S. , Gimpel S.D. , Cosman D. , Williams D.E.
      Cell63:235-243(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: WCB6F1.
    2. 2.
      "Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2."
      Huang E.J. , Nocka K.H. , Buck J. , Besmer P.
      Mol. Biol. Cell3:349-362(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2)
    3. 3.
      "Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant."
      Flanagan J.G. , Chan D.C. , Leder P.
      Cell64:1025-1035(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2)
      strain: WCB6F1.
    4. 4.
      "Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail."
      Brannan C.I. , Bedell M.A. , Resnick J.L. , Eppig J.J. , Handel M.A. , Williams D.E. , Lyman S.D. , Donovan P.J. , Jenkins N.A. , Copeland N.G.
      Genes Dev.6:1832-1842(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
    5. 5.
      "Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene."
      Bedell M.A. , Copeland N.G. , Jenkins N.A.
      Genetics142:927-934(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
      strain: C57BL/6J.
    6. 6.
      "Molecular analysis of two new Steel mutations in mice shows a transversion or an insertion."
      Graw J. , Loester J. , Neuhaeuser-Klaus A. , Pretsch W. , Schmitt-John T.
      Mamm. Genome7:843-846(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS PRO-193 AND SER-207
      strain: C3H/E1.
      tissue: Brain.
    7. 7.
      "Detection of a point mutation (A to G) in exon 5 of the murine Mgf gene defines a novel allele at the Steel locus with a weak phenotype."
      Graw J. , Neuhauser-Klaus A. , Pretsch W.
      Mutat. Res.382:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS SER-122; PRO-193 AND SER-207
      strain: 102/E1 X C3H/E1.
    8. 8.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Testis.
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-207
    10. 10.
      "The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus."
      Huang E. , Nocka K. , Beier D.R. , Chu T.Y. , Buck J. , Lahm H.W. , Wellner D. , Leder P. , Besmer P.
      Cell63:225-233(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-270 (ISOFORM 1);PROTEIN SEQUENCE OF 26-65
    11. 11.
      "Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor."
      Zsebo K.M. , Williams D.A. , Geissler E.N. , Broudy V.C. , Martin F.H. , Atkins H.L. , Hsu R.-Y. , Birkett N.C. , Okino K.H. , Murdock D.C. , Jacobsen F.W. , Langley K.E. , Smith K.A. , Takeishi T. , Cattanach B.M. , Galli S.J. , Suggs S.V.
      Cell63:213-224(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-201
    12. 12.
      "Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles."
      Copeland N.G. , Gilbert D.J. , Cho B.C. , Donovan P.J. , Jenkins N.A. , Cosman D. , Anderson D. , Lyman S.D. , Williams D.E.
      Cell63:175-183(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-53
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-78
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      "Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases."
      Liu H. , Chen X. , Focia P.J. , He X.
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 28-166 ALONE AND IN COMPLEX WITH KIT;SUBUNIT;DISULFIDE BONDS
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