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Index > Protein center > Tek(Gene name) > Mouse
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  • Tek (Gene name),
  • Angiopoietin-1 receptor (Protein name ),  TIE2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Tek(Hyk;Tie-2;Tie2);
    Protein name:
    Angiopoietin-1 receptor;
    Alternative:
    STK1;HYK;Tyrosine-protein kinase receptor TEK;Tunica interna endothelial cell kinase;p140 TEK;Tyrosine-protein kinase receptor TIE-2(mTIE2);p140 TEK;Tyrosine-protein kinase receptor TIE-2(mTIE2);
    CD:
    CD202b;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PTPRB.
    Function:
    This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1122
    Sequence:
    50:
    MDSLAGLVLC | GVSLLLYGVV | EGAMDLILIN | SLPLVSDAET | SLTCIASGWH | 
    100:
    PHEPITIGRD | FEALMNQHQD | PLEVTQDVTR | EWAKKVVWKR | EKASKINGAY | 
    150:
    FCEGRVRGQA | IRIRTMKMRQ | QASFLPATLT | MTVDRGDNVN | ISFKKVLIKE | 
    200:
    EDAVIYKNGS | FIHSVPRHEV | PDILEVHLPH | AQPQDAGVYS | ARYIGGNLFT | 
    250:
    SAFTRLIVRR | CEAQKWGPDC | SRPCTTCKNN | GVCHEDTGEC | ICPPGFMGRT | 
    300:
    CEKACEPHTF | GRTCKERCSG | PEGCKSYVFC | LPDPYGCSCA | TGWRGLQCNE | 
    350:
    ACPSGYYGPD | CKLRCHCTNE | EICDRFQGCL | CSQGWQGLQC | EKEGRPRMTP | 
    400:
    QIEDLPDHIE | VNSGKFNPIC | KASGWPLPTS | EEMTLVKPDG | TVLQPNDFNY | 
    450:
    TDRFSVAIFT | VNRVLPPDSG | VWVCSVNTVA | GMVEKPFNIS | VKVLPEPLHA | 
    500:
    PNVIDTGHNF | AIINISSEPY | FGDGPIKSKK | LFYKPVNQAW | KYIEVTNEIF | 
    550:
    TLNYLEPRTD | YELCVQLARP | GEGGEGHPGP | VRRFTTASIG | LPPPRGLSLL | 
    600:
    PKSQTALNLT | WQPIFTNSED | EFYVEVERRS | LQTTSDQQNI | KVPGNLTSVL | 
    650:
    LSNLVPREQY | TVRARVNTKA | QGEWSEELRA | WTLSDILPPQ | PENIKISNIT | 
    700:
    DSTAMVSWTI | VDGYSISSII | IRYKVQGKNE | DQHIDVKIKN | ATVTQYQLKG | 
    750:
    LEPETTYHVD | IFAENNIGSS | NPAFSHELRT | LPHSPASADL | GGGKMLLIAI | 
    800:
    LGSAGMTCIT | VLLAFLIMLQ | LKRANVQRRM | AQAFQNREEP | AVQFNSGTLA | 
    850:
    LNRKAKNNPD | PTIYPVLDWN | DIKFQDVIGE | GNFGQVLKAR | IKKDGLRMDA | 
    900:
    AIKRMKEYAS | KDDHRDFAGE | LEVLCKLGHH | PNIINLLGAC | EHRGYLYLAI | 
    950:
    EYAPHGNLLD | FLRKSRVLET | DPAFAIANST | ASTLSSQQLL | HFAADVARGM | 
    1000:
    DYLSQKQFIH | RDLAARNILV | GENYIAKIAD | FGLSRGQEVY | VKKTMGRLPV | 
    1050:
    RWMAIESLNY | SVYTTNSDVW | SYGVLLWEIV | SLGGTPYCGM | TCAELYEKLP | 
    1100:
    QGYRLEKPLN | CDDEVYDLMR | QCWREKPYER | PSFAQILVSL | NRMLEERKTY | 
    1122:
    VNTTLYEKFT | YAGIDCSAEE | AA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Angiopoietin-1 receptor
    Cat.:
    E0126h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Angiopoietin-1 receptor
    Cat.:
    E0126m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Angiopoietin-1 receptor
    Cat.:
    E0126b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Angiopoietin-1 receptor
    Cat.:
    U0126m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Angiopoietin-1 receptor
    Cat.:
    U0126h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Angiopoietin-1 receptor
    Cat.:
    U0126b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Angiopoietin-1 receptor
    Cat.:
    P0126Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Angiopoietin-1 receptor
    Polyclonal Antibody for Mouse Angiopoietin-1 receptor
    Cat.:
    P0126Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Angiopoietin-1 receptor
    Monoclonal Antibody for Mouse Angiopoietin-1 receptor
    Monoclonal Antibody for Mouse Angiopoietin-1 receptor
    Protein for Mouse Angiopoietin-1 receptor
    Protein for Mouse Angiopoietin-1 receptor
    Protein for Mouse Angiopoietin-1 receptor

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system."
      Sato T.N. , Qin Y. , Kozak C.A. , Andus K.L.
      Proc. Natl. Acad. Sci. U.S.A.90:9355-9358(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Lung.
    2. 2.
      "The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors."
      Dumont D.J. , Gradwol G.J. , Fong G.-H. , Auerbach R. , Breitman M.L.
      Oncogene8:1293-1301(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: CD-1.
      tissue: Embryonic heart.
    3. 3.
      "A novel tyrosine kinase, hyk, expressed in murine embryonic stem cells."
      Horita K. , Yagi T. , Kohmura N. , Tomooka Y. , Ikawa Y. , Aizawa S.
      Biochem. Biophys. Res. Commun.189:1747-1753(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Embryonic stem cell.
    4. 4.
      "Tie2, a putative protein tyrosine kinase from a new class of cell surface receptor."
      Runting A.S. , Stacker S.A. , Wilks A.F.
      Growth Factors9:99-105(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
    5. 5.
      "Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage."
      Schnuerch H. , Risau W.
      Development119:957-968(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells."
      Iwama A. , Hamaguchi I. , Hashiyama M. , Murayama Y. , Yasunaga K. , Suda T.
      Biochem. Biophys. Res. Commun.195:301-309(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Hematopoietic stem cell.
    7. 7.
      "Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors."
      Dumont D.J. , Yamaguchi T.P. , Conlon R.A. , Rossant J. , Breitman M.L.
      Oncogene7:1471-1480(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 822-1122
      strain: CD-1.
      tissue: Embryonic heart.
    8. 8.
      "Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo."
      Dumont D.J. , Gradwohl G. , Fong G.H. , Puri M.C. , Gertsenstein M. , Auerbach A. , Breitman M.L.
      Genes Dev.8:1897-1909(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;MUTAGENESIS OF LYS-853;CATALYTIC ACTIVITY;FUNCTION
    9. 9.
      "Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation."
      Sato T.N. , Tozawa Y. , Deutsch U. , Wolburg-Buchholz K. , Fujiwara Y. , Gendron-Maguire M. , Gridley T. , Wolburg H. , Risau W. , Qin Y.
      Nature376:70-74(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    10. 10.
      "Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt."
      Kontos C.D. , Stauffer T.P. , Yang W.P. , York J.D. , Huang L. , Blanar M.A. , Meyer T. , Peters K.G.
      Mol. Cell. Biol.18:4131-4140(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1;MUTAGENESIS OF TYR-1100;FUNCTION IN ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND AKT1
    11. 11.
      "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration."
      Jones N. , Master Z. , Jones J. , Bouchard D. , Gunji Y. , Sasaki H. , Daly R. , Alitalo K. , Dumont D.J.
      J. Biol. Chem.274:30896-30905(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; GRB7;GRB14;PTPN11/SHP2 AND PIK3R1;FUNCTION IN PHOSPHORYLATION OF GRB7 AND PIK3R1;MUTAGENESIS OF TYR-1100
    12. 12.
      "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2."
      Fachinger G. , Deutsch U. , Risau W.
      Oncogene18:5948-5953(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPRB
    13. 13.
      "Rescue of the early vascular defects in Tek/Tie2 null mice reveals an essential survival function."
      Jones N. , Voskas D. , Master Z. , Sarao R. , Jones J. , Dumont D.J.
      EMBO Rep.2:438-445(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ANTI-APOPTOTIC FUNCTION
    14. 14.
      "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."
      Fiedler U. , Krissl T. , Koidl S. , Weiss C. , Koblizek T. , Deutsch U. , Martiny-Baron G. , Marme D. , Augustin H.G.
      J. Biol. Chem.278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANGPT1 AND ANGPT2;DOMAIN
    15. 15.
      "A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function."
      Jones N. , Chen S.H. , Sturk C. , Master Z. , Tran J. , Kerbel R.S. , Dumont D.J.
      Mol. Cell. Biol.23:2658-2668(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-1100 AND TYR-1106;MUTAGENESIS OF LYS-853; TYR-1100 AND TYR-1106;FUNCTION IN DOK2 PHOSPHORYLATION;INTERACTION WITH DOK2
    16. 16.
      "Biological characterization of angiopoietin-3 and angiopoietin-4."
      Lee H.J. , Cho C.H. , Hwang S.J. , Choi H.H. , Kim K.T. , Ahn S.Y. , Kim J.H. , Oh J.L. , Lee G.M. , Koh G.Y.
      FASEB J.18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS ANGPT4 RECEPTOR AND IN ACTIVATION OF AKT1;INTERACTION WITH ANGPT4;AUTOPHOSPHORYLATION
    17. 17.
      "VE-PTP controls blood vessel development by balancing Tie-2 activity."
      Winderlich M. , Keller L. , Cagna G. , Broermann A. , Kamenyeva O. , Kiefer F. , Deutsch U. , Nottebaum A.F. , Vestweber D.
      J. Cell Biol.185:657-671(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRB
    18. 18.
      "Tyrosine phosphorylation of Grb14 by Tie2."
      Sturk C. , Dumont D.J.
      Cell Commun. Signal.8:30-30(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB14;FUNCTION IN GRB14 PHOSPHORYLATION
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