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Index > Protein center > FASLG(Gene name) > Human
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  • FASLG (Gene name),
  • Tumor necrosis factor ligand superfamily member 6 (Protein name ),  TNFL6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FASLG(APT1LG1;CD95L;FASL;TNFSF6);
    Protein name:
    Tumor necrosis factor ligand superfamily member 6;
    Alternative:
    Fas antigen ligand(Fas ligand);Apoptosis antigen ligand(APTL);CD95 ligand(CD95-L);
    CD:
    CD178;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.
    Function:
    Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
    Subcellular Location:
    Cell membrane Single-pass type II membrane protein Secreted Cytoplasmic vesicle lumen Lysosome lumen May be released into the extracellular fluid, probably by cleavage form the cell surface. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination.
    Protein Attributes:
    Sequence length:
    281
    Sequence:
    50:
    MQQPFNYPYP | QIYWVDSSAS | SPWAPPGTVL | PCPTSVPRRP | GQRRPPPPPP | 
    100:
    PPPLPPPPPP | PPLPPLPLPP | LKKRGNHSTG | LCLLVMFFMV | LVALVGLGLG | 
    150:
    MFQLFHLQKE | LAELRESTSQ | MHTASSLEKQ | IGHPSPPPEK | KELRKVAHLT | 
    200:
    GKSNSRSMPL | EWEDTYGIVL | LSGVKYKKGG | LVINETGLYF | VYSKVYFRGQ | 
    250:
    SCNNLPLSHK | VYMRNSKYPQ | DLVMMEGKMM | SYCTTGQMWA | RSSYLGAVFN | 
    281:
    LTSADHLYVN | VSELSLVNFE | ESQTFFGLYK | L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    Pfam:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
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    E0031m
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
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    E0031r
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
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    E0031h
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
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    E0031p
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    96T
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
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    U0031p
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    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
    Cat.:
    U0031h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
    Cat.:
    U0031m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
    Cat.:
    U0031r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Cat.:
    P0031Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Cat.:
    P0031Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Cat.:
    P0031Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
    Protein for Human Tumor necrosis factor ligand superfamily member 6
    Protein for Human Tumor necrosis factor ligand superfamily member 6
    Protein for Human Tumor necrosis factor ligand superfamily member 6
    Protein for Human Tumor necrosis factor ligand superfamily member 6

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Fas ligand mediates activation-induced cell death in human T lymphocytes."
      Alderson M.
      J. Exp. Med.181:71-77(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Human Fas ligand: gene structure, chromosomal location and species specificity."
      Takahashi T. , Tanaka M. , Inazawa J. , Abe T. , Suda T. , Nagata S.
      Int. Immunol.6:1567-1574(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      Schaetzlein C.E. , Poehlmann R. , Philippsen P. , Eibel H.
      Submitted (1995-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Role of Fas ligand in apoptosis induced by hepatitis C virus infection."
      Mita E. , Hayashi N. , Iio S. , Takehara T. , Hijioka T. , Kasahara A. , Fusamoto H. , Kamada T.
      Biochem. Biophys. Res. Commun.204:468-474(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Isolation and characterization of a new naturally occurring variant of human Fas ligand that is expressed only in membrane bound form."
      Zeytun A. , Nagarkatti M. , Nagarkatti P.S.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Leukocyte.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Blood.
    8. 8.
      Matsumura M. , Nakanishi Y. , Ohba Y.
      Submitted (1998-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10
      tissue: Blood.
    9. 9.
      "Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease."
      Wu J. , Wilson J. , He J. , Xiang L. , Schur P.H. , Mountz J.D.
      J. Clin. Invest.98:1107-1113(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ALPS1B
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;MUTAGENESIS OF PRO-206; TYR-218 AND PHE-275
    11. 11.
      "Downregulation of Fas ligand by shedding."
      Tanaka M. , Itai T. , Adachi M. , Nagata S.
      Nat. Med.4:31-36(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    12. 12.
      "The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells."
      Kirkin V. , Cahuzac N. , Guardiola-Serrano F. , Huault S. , Luckerath K. , Friedmann E. , Novac N. , Wels W.S. , Martoglio B. , Hueber A.O. , Zornig M.
      Cell Death Differ.14:1678-1687(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF FASL INTRACELLULAR DOMAIN;CLEAVAGE BY ADAM10 AND SPPL2A;SUBCELLULAR LOCATION
    13. 13.
      "Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation."
      Zuccato E. , Blott E.J. , Holt O. , Sigismund S. , Shaw M. , Bossi G. , Griffiths G.M.
      J. Cell Sci.120:191-199(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;PHOSPHORYLATION;INTERACTION WITH FGR; FYN AND LYN;SUBCELLULAR LOCATION
    14. 14.
      "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
      Voss M. , Lettau M. , Janssen O.
      BMC Immunol.10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGAP9; BAIAP2L1; BTK; CACNB3; CACNB4; CRK; DLG2; DNMBP; DOCK4; EPS8L3; FYB; FYN; HCK; ITK; ITSN2; KALRN; LYN; MACC1; MIA; MPP4; MYO15A; NCF1; NCK1; NCK2; NCKIPSD; OSTF1; PIK3R1; PSTPIP1; RIMBP3C; SAMSN1; SH3GL3; SH3PXD2B; SH3PXD2A; SH3RF2; SKAP2; SNX33; SNX9; SORBS3; SPTA1; SRC; SRGAP1; SRGAP2; SRGAP3; TEC; TJP3 AND YES1
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