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Index > Protein center > TNFRSF11B(Gene name) > Human
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  • TNFRSF11B (Gene name),
  • Tumor necrosis factor receptor superfamily member 11B (Protein name ),  TR11B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (3)
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  • Gene name:
    TNFRSF11B(OCIF;OPG);
    Protein name:
    Tumor necrosis factor receptor superfamily member 11B;
    Alternative:
    Osteoclastogenesis inhibitory factor;Osteoprotegerin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    401
    Sequence:
    50:
    MNNLLCCALV | FLDISIKWTT | QETFPPKYLH | YDEETSHQLL | CDKCPPGTYL | 
    100:
    KQHCTAKWKT | VCAPCPDHYY | TDSWHTSDEC | LYCSPVCKEL | QYVKQECNRT | 
    150:
    HNRVCECKEG | RYLEIEFCLK | HRSCPPGFGV | VQAGTPERNT | VCKRCPDGFF | 
    200:
    SNETSSKAPC | RKHTNCSVFG | LLLTQKGNAT | HDNICSGNSE | STQKCGIDVT | 
    250:
    LCEEAFFRFA | VPTKFTPNWL | SVLVDNLPGT | KVNAESVERI | KRQHSSQEQT | 
    300:
    FQLLKLWKHQ | NKDQDIVKKI | IQDIDLCENS | VQRHIGHANL | TFEQLRSLME | 
    350:
    SLPGKKVGAE | DIEKTIKACK | PSDQILKLLS | LWRIKNGDQD | TLKGLMHALK | 
    400:
    HSKTYHFPKT | VTQSLKKTIR | FLHSFTMYKL | YQKLFLEMIG | NQVQSVKISC | 
    401:
    L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    String:
    UniGene:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108h
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    96T
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    P0108Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    P0108Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    P0108Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 11B
    Protein for Human Tumor necrosis factor receptor superfamily member 11B
    Protein for Human Tumor necrosis factor receptor superfamily member 11B
    Protein for Human Tumor necrosis factor receptor superfamily member 11B
    Protein for Human Tumor necrosis factor receptor superfamily member 11B

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.1%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.9%

    Intra-Assay CV: ≤2.3

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery

    Recovery was determined by spiking various levels of TR11B into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    97

    92-98

    Plasma

    98

    95-102

     

     

     

     

    Inter-Assay CV: ≤7.5

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of TR11B and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    93-100%

    93-99%

    95-102%

    93-98%

    EDTA plasma(n=5)

    90-96%

    95-102%

    101-105%

    94-103%

    heparin plasma(n=5)

    94-99%

     

    96-104%

    95-100%

    92-104%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LYS-3
      tissue: Kidney.
    2. 2.
      "Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro."
      Yasuda H. , Shima N. , Nakagawa N. , Mochizuki S. , Yano K. , Fujise N. , Sato Y. , Goto M. , Yamaguchi K. , Kuriyama M. , Kanno T. , Murakami A. , Tsuda E. , Morinaga T. , Higashio K.
      Endocrinology139:1329-1337(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LYS-3
      tissue: Lung cancer.
    3. 3.
      "Cloning and characterization of the gene encoding human osteoprotegerin/osteoclastogenesis-inhibitory factor."
      Morinaga T. , Nakagawa N. , Yasuda H. , Tsuda E. , Higashio K.
      Eur. J. Biochem.254:685-691(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LYS-3
      tissue: Placenta.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LYS-3
      tissue: Kidney.
    5. 5.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    6. 6.
      NIEHS SNPs program
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-3 AND MET-104
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
    8. 9.
      "Characterization of monomeric and homodimeric forms of osteoclastogenesis inhibitory factor."
      Tomoyasu A. , Goto M. , Fujise N. , Mochizuki S. , Yasuda H. , Morinaga T. , Tsuda E. , Higashio K.
      Biochem. Biophys. Res. Commun.245:382-387(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-36 AND 378-401
    9. 10.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-36
    10. 11.
      "Cloning and expression of a novel mutated osteoprogerin/osteoclastogenesis inhibitory factor gene."
      He Z.-Y. , Yang G.-Z. , Zhang W.-J. , Wu X.-F.
      Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao31:680-684(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-393
      tissue: Placenta.
    11. 12.
      "Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis."
      Tsuda E. , Goto M. , Mochizuki S. , Yano K. , Kobayashi F. , Morinaga T. , Higashio K.
      Biochem. Biophys. Res. Commun.234:137-142(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 242-255; 354-359 AND 369-378;FUNCTION
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNFSF10
    13. 14.
      "Characterization of structural domains of human osteoclastogenesis inhibitory factor."
      Yamaguchi K. , Kinosaki M. , Goto M. , Kobayashi F. , Tsuda E. , Morinaga T. , Higashio K.
      J. Biol. Chem.273:5117-5123(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;MUTAGENESIS OF CYS-400
    14. 15.
      "Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseases."
      Hofbauer L.C. , Neubauer A. , Heufelder A.E.
      Cancer92:460-470(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    15. 16.
      "Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."
      Luan X. , Lu Q. , Jiang Y. , Zhang S. , Wang Q. , Yuan H. , Zhao W. , Wang J. , Wang X.
      J. Immunol.189:245-252(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 22-186 IN COMPLEX WITH TNFSF11;INTERACTION WITH TNFSF11;SUBUNIT;FUNCTION;MUTAGENESIS OF 78-ASP-GLU-79 AND GLU-116;GLYCOSYLATION AT ASN-178;DISULFIDE BONDS
    16. 17.
      "A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype."
      Cundy T. , Hegde M. , Naot D. , Chong B. , King A. , Wallace R. , Mulley J. , Love D.R. , Seidel J. , Fawkner M. , Banovic T. , Callon K.E. , Grey A.B. , Reid I.R. , Middleton-Hardie C.A. , Cornish J.
      Hum. Mol. Genet.11:2119-2127(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT JPD ASP-182 DEL
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