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Index > Protein center > Tnfrsf11b(Gene name) > Mouse
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  • Tnfrsf11b (Gene name),
  • Tumor necrosis factor receptor superfamily member 11B (Protein name ),  TR11B_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    Tnfrsf11b(Ocif;Opg);
    Protein name:
    Tumor necrosis factor receptor superfamily member 11B;
    Alternative:
    Osteoclastogenesis inhibitory factor;Osteoprotegerin;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    401
    Sequence:
    50:
    MNKWLCCALL | VLLDIIEWTT | QETLPPKYLH | YDPETGHQLL | CDKCAPGTYL | 
    100:
    KQHCTVRRKT | LCVPCPDHSY | TDSWHTSDEC | VYCSPVCKEL | QSVKQECNRT | 
    150:
    HNRVCECEEG | RYLEIEFCLK | HRSCPPGSGV | VQAGTPERNT | VCKKCPDGFF | 
    200:
    SGETSSKAPC | IKHTNCSTFG | LLLIQKGNAT | HDNVCSGNRE | ATQKCGIDVT | 
    250:
    LCEEAFFRFA | VPTKIIPNWL | SVLVDSLPGT | KVNAESVERI | KRRHSSQEQT | 
    300:
    FQLLKLWKHQ | NRDQEMVKKI | IQDIDLCESS | VQRHLGHSNL | TTEQLLALME | 
    350:
    SLPGKKISPE | EIERTRKTCK | SSEQLLKLLS | LWRIKNGDQD | TLKGLMYALK | 
    400:
    HLKTSHFPKT | VTHSLRKTMR | FLHSFTMYRL | YQKLFLEMIG | NQVQSVKISC | 
    401:
    L
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    E0108b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    U0108h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    P0108Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    P0108Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Cat.:
    P0108Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 11B
    Protein for Mouse Tumor necrosis factor receptor superfamily member 11B
    Protein for Mouse Tumor necrosis factor receptor superfamily member 11B
    Protein for Mouse Tumor necrosis factor receptor superfamily member 11B
    Protein for Mouse Tumor necrosis factor receptor superfamily member 11B

    R&D Technical Data

    s

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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.1%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.9%

    Intra-Assay CV: ≤2.3

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery

    Recovery was determined by spiking various levels of TR11B into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    97

    92-98

    Plasma

    98

    95-102

     

     

     

     

    Inter-Assay CV: ≤7.5

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    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of TR11B and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    93-100%

    93-99%

    95-102%

    93-98%

    EDTA plasma(n=5)

    90-96%

    95-102%

    101-105%

    94-103%

    heparin plasma(n=5)

    94-99%

     

    96-104%

    95-100%

    92-104%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Kidney.
    2. 2.
      "Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis."
      Mizuno A. , Murakami A. , Nakagawa N. , Yasuda H. , Tsuda E. , Morinaga T. , Higashio K.
      Gene215:339-343(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANTS PRO-138; ARG-161; ASP-165; ALA-288 AND ARG-296
      strain: 129/Ola.
      strain: NIH Swiss.
      tissue: Fibroblast.
    3. 3.
      "Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis."
      Min H. , Morony S. , Sarosi I. , Dunstan C.R. , Capparelli C. , Scully S. , Van G. , Kaufman S. , Kostenuik P.J. , Lacey D.L. , Boyle W.J. , Simonet W.S.
      J. Exp. Med.192:463-474(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    4. 4.
      "RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor."
      Nelson C.A. , Warren J.T. , Wang M.W. , Teitelbaum S.L. , Fremont D.H.
      Structure20:1971-1982(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 22-197 IN COMPLEX WITH TNFSF11/RANKL;DISULFIDE BONDS
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