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Index > Protein center > TXNIP(Gene name) > Human
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  • TXNIP (Gene name),
  • Thioredoxin-interacting protein (Protein name ),  TXNIP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    TXNIP(VDUP1);
    Protein name:
    Thioredoxin-interacting protein;
    Alternative:
    Thioredoxin-binding protein 2;Vitamin D3 up-regulated protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains).
    Function:
    May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    391
    Sequence:
    50:
    MVMFKKIKSF | EVVFNDPEKV | YGSGEKVAGR | VIVEVCEVTR | VKAVRILACG | 
    100:
    VAKVLWMQGS | QQCKQTSEYL | RYEDTLLLED | QPTGENEMVI | MRPGNKYEYK | 
    150:
    FGFELPQGPL | GTSFKGKYGC | VDYWVKAFLD | RPSQPTQETK | KNFEVVDLVD | 
    200:
    VNTPDLMAPV | SAKKEKKVSC | MFIPDGRVSV | SARIDRKGFC | EGDEISIHAD | 
    250:
    FENTCSRIVV | PKAAIVARHT | YLANGQTKVL | TQKLSSVRGN | HIISGTCASW | 
    300:
    RGKSLRVQKI | RPSILGCNIL | RVEYSLLIYV | SVPGSKKVIL | DLPLVIGSRS | 
    350:
    GLSSRTSSMA | SRTSSEMSWV | DLNIPDTPEA | PPCYMDVIPE | DHRLESPTTP | 
    391:
    LLDDMDGSQD | SPIFMYAPEF | KFMPPPTYTE | VDPCILNNNV | Q
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    KEGG:
    String:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Thioredoxin-interacting protein
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    E1162h
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    ELISA Kit for Human Thioredoxin-interacting protein
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    E1162p
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    Packing:
    96T
    ELISA Kit for Human Thioredoxin-interacting protein
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    E1162m
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    Packing:
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    ELISA Kit for Human Thioredoxin-interacting protein
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    E1162r
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    Packing:
    96T
    CLIA Kit for Human Thioredoxin-interacting protein
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    U1162p
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    Packing:
    96T
    CLIA Kit for Human Thioredoxin-interacting protein
    Cat.:
    U1162m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Thioredoxin-interacting protein
    Cat.:
    U1162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Thioredoxin-interacting protein
    Cat.:
    U1162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    Polyclonal Antibody for Human Thioredoxin-interacting protein
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    P1162Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Thioredoxin-interacting protein
    Polyclonal Antibody for Human Thioredoxin-interacting protein
    Cat.:
    P1162Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Thioredoxin-interacting protein
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    P1162Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Thioredoxin-interacting protein
    Monoclonal Antibody for Human Thioredoxin-interacting protein
    Monoclonal Antibody for Human Thioredoxin-interacting protein
    Monoclonal Antibody for Human Thioredoxin-interacting protein
    Protein for Human Thioredoxin-interacting protein
    Protein for Human Thioredoxin-interacting protein
    Protein for Human Thioredoxin-interacting protein
    Protein for Human Thioredoxin-interacting protein

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    Citations
    [1].
    Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
    References
    1. 1.
      "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3."
      Chen K.-S. , DeLuca H.F.
      Biochim. Biophys. Acta1219:26-32(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION
    2. 2.
      "Regulation of the bioavailability of thioredoxin in the lens by a specific thioredoxin-binding protein (TBP-2)."
      Liyanage N.P.M. , Fernando M.R. , Lou M.F.
      Exp. Eye Res.85:270-279(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH TXN;INDUCTION
      tissue: Lens.
    3. 3.
      "Homo sapiens VDUP1 gene."
      Toyama S.
      Submitted (2000-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Uterus.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    7. 7.
      "Cloning and characterization of human VDUP1 gene."
      Park J.B.
      Submitted (2001-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-38
    8. 8.
      "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression."
      Han S.H. , Jeon J.H. , Ju H.R. , Jung U. , Kim K.Y. , Yoo H.S. , Lee Y.H. , Song K.S. , Hwang H.M. , Na Y.S. , Yang Y. , Lee K.N. , Choi I.
      Oncogene22:4035-4046(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;INTERACTION WITH ZBTB16; ZBTB32 AND HDAC1
    9. 9.
      "hnRNP G elicits tumor-suppressive activity in part by upregulating the expression of Txnip."
      Shin K.H. , Kim R.H. , Kim R.H. , Kang M.K. , Park N.H.
      Biochem. Biophys. Res. Commun.372:880-885(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation."
      Zhang P. , Wang C. , Gao K. , Wang D. , Mao J. , An J. , Xu C. , Wu D. , Yu H. , Liu J.O. , Yu L.
      J. Biol. Chem.285:8869-8879(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITCH;UBIQUITINATION BY ITCH
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1."
      Jin H.O. , Seo S.K. , Kim Y.S. , Woo S.H. , Lee K.H. , Yi J.Y. , Lee S.J. , Choe T.B. , Lee J.H. , An S. , Hong S.I. , Park I.C.
      Oncogene30:3792-3801(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DDIT4
    14. 14.
      "Structure of the N-terminal domain of human thioredoxin-interacting protein."
      Polekhina G. , Ascher D.B. , Kok S.F. , Beckham S. , Wilce M. , Waltham M.
      Acta Crystallogr. D69:333-344(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 2-149;SUBUNIT;INTERCHAIN DISULFIDE BOND
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