Cdh1 Protein for Mouse(Mus musculus) | EIAab.comCdh1 Protein for Mouse(Mus musculus)

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Cdh1 (Gene name),

Cadherin-1 (Protein name ), CADH1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cdh1;

Protein name:

Cadherin-1;

Alternative:

Epithelial cadherin(E-cadherin);ARC-1;Uvomorulin;

CD:

CD324;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1, beta-catenin/CTNNB1 or gamma-catenin/JUP, and potentially alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Alternatively, the CTNNA1-containing complex may be linked to F-actin by other proteins such as LIMA1. Interaction with PSEN1, cleaves CDH1 resulting in the disassociation of cadherin-based adherens junctions (CAJs). Interacts with AJAP1, CTNND1 and DLGAP5 (By similarity). Interacts with TBC1D2. Interacts with LIMA1. Interacts with CAV1 (By similarity). Interacts with the TRPV4 and CTNNB1 complex.

Function:

E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Subcellular Location:

Cell junction Cell membrane Single-pass type I membrane protein Endosome Golgi apparatus trans-Golgi network Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.

Protein Attributes:

Sequence length:

884

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

884:

NSSESDQDQD | YDYLNEWGNR | FKKLADMYGG | GEDD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P09803

Pfam:

PF00028

UniGene:

Mm.35605

SMR:

P09803

KEGG:

mmu:12550

Uniprot:

P09803

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ELISA Kit for Mouse Cadherin-1

Cat.:

E0017h

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96T

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ELISA Kit for Mouse Cadherin-1

Cat.:

E0017m

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96T

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ELISA Kit for Mouse Cadherin-1

Cat.:

E0017r

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96T

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ELISA Kit for Mouse Cadherin-1

Cat.:

E0017d

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96T

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ELISA Kit for Mouse Cadherin-1

Cat.:

E0017b

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96T

ELISA Kit for Mouse Cadherin-1

Cat.:

E0017c

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96T

CLIA Kit for Mouse Cadherin-1

Cat.:

U0017b

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96T

CLIA Kit for Mouse Cadherin-1

Cat.:

U0017c

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96T

CLIA Kit for Mouse Cadherin-1

Cat.:

U0017d

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96T

CLIA Kit for Mouse Cadherin-1

Cat.:

U0017h

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96T

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CLIA Kit for Mouse Cadherin-1

Cat.:

U0017m

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Looking for manual.

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96T

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CLIA Kit for Mouse Cadherin-1

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U0017r

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96T

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Polyclonal Antibody for Mouse Cadherin-1

Cat.:

P0017Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Cadherin-1

Cat.:

P0017Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse Cadherin-1

Cat.:

P0017Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Cadherin-1

Monoclonal Antibody for Mouse Cadherin-1

Protein for Mouse Cadherin-1

Cat.:

R0017m

Price:

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Packing:

1mg

Purity:

>90%

Protein for Mouse Cadherin-1

R&D Technical Data

12% SDS-PAGE Analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤ 6.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤ 11.2%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	102	96-105
Plasma	104	94-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	93-105%	94-103%	95-105%	92-108%
EDTA plasma(n=5)	89-98%	93-101%	90-99%	90-104%
heparin plasma(n=5)	93-101%	92-102%	99-109%	94-107%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA."
Nagafuchi A. , Shirayoshi Y. , Okazari K. , Yasuda K. , Takeichi M.
Nature329:341-343(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: ICR.
2.

"The structure of the gene coding for the mouse cell adhesion molecule uvomorulin."
Ringwald M. , Baribault H. , Schmidt C. , Kemler R.
Nucleic Acids Res.19:6533-6539(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/Sv.
3.

"The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion."
Ringwald M. , Schuh R. , Vestweber D. , Eistetter H. , Lottspeich F. , Engel J. , Doelz R. , Jaehnig F. , Epplen J. , Mayer S. , Mueller C. , Kemler R.
EMBO J.6:3647-3653(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 174-884;PROTEIN SEQUENCE OF 157-181
4.

"The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element."
Behrens J. , Loewrick O. , Klein-Hitpass L. , Birchmeier W.
Proc. Natl. Acad. Sci. U.S.A.88:11495-11499(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15
5.

"Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion."
Butz S. , Kemler R.
FEBS Lett.355:195-200(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN AN E-CADHERIN/CATENIN ADHESION COMPLEX
6.

"A comprehensive survey of the cadherins expressed in the testes of fetal, immature, and adult mice utilizing the polymerase chain reaction."
Munro S.B. , Blaschuk O.W.
Biol. Reprod.55:822-827(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
strain: C57BL/6.
tissue: Testis.
7.

"Deconstructing the cadherin-catenin-actin complex."
Yamada S. , Pokutta S. , Drees F. , Weis W.I. , Nelson W.J.
Cell123:889-901(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECONSTITUTION OF THE E-CADHERIN/CATENIN ADHESION COMPLEX;LACK OF ACTIN-BINDING BY THE E-CADHERIN/CATENIN ADHESION COMPLEX
8.

"EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt."
Abe K. , Takeichi M.
Proc. Natl. Acad. Sci. U.S.A.105:13-19(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF ACTIN-BINDING BY THE E-CADHERIN/CATENIN ADHESION COMPLEX
9.

"The TRPV4 channel contributes to intercellular junction formation in keratinocytes."
Sokabe T. , Fukumi-Tominaga T. , Yonemura S. , Mizuno A. , Tominaga M.
J. Biol. Chem.285:18749-18758(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRPV4 AND CTNNB1
10.

"Structural basis of calcium-induced E-cadherin rigidification and dimerization."
Nagar B. , Overduin M. , Ikura M. , Rini J.M.
Nature380:360-364(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 157-370;CALCIUM-BINDING SITES
11.

"1H, 15N and 13C resonance assignments and monomeric structure of the amino-terminal extracellular domain of epithelial cadherin."
Overduin M. , Tong K.I. , Kay C.M. , Ikura M.
J. Biomol. NMR7:173-189(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 157-260
12.

"The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin."
Huber A.H. , Weis W.I.
Cell105:391-402(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 577-728 IN COMPLEX WITH CTNNB1;PHOSPHORYLATION
13.

"Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes."
Choi H.J. , Gross J.C. , Pokutta S. , Weis W.I.
J. Biol. Chem.284:31776-31788(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 778-884 IN COMPLEX WITH HUMAN JUP;PHOSPHORYLATION AT SER-840; SER-842 AND SER-848

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