CTGF Protein for Human(Homo sapiens) | EIAab.comCTGF Protein for Human(Homo sapiens)

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Index > Protein center > CTGF(Gene name) > Human

CTGF (Gene name),

Connective tissue growth factor (Protein name ), CTGF_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CTGF(CCN2;HCS24;IGFBP8);

Protein name:

Connective tissue growth factor;

Alternative:

Hypertrophic chondrocyte-specific protein 24;CCN family member 2;Insulin-like growth factor-binding protein 8(IBP-8;IGF-binding protein 8;IGFBP-8);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Subcellular Location:

Secreted extracellular space extracellular matrix Secreted

Protein Attributes:

Sequence length:

349

Sequence:

50:

100:

150:

200:

250:

300:

349:

LPVEFKCPDG | EVMKKNMMFI | KTCACHYNCP | GDNDIFESLY | YRKMYGDMA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

121009

String:

P29279

STRING:

9606.ENSP00000356954

UniGene:

Hs.410037

KEGG:

hsa:1490

SMR:

P29279

Pfam:

PF00007

Uniprot:

P29279

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ELISA Kit for Human Connective tissue growth factor

Cat.:

E0010h

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Packing:

96T

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ELISA Kit for Human Connective tissue growth factor

Cat.:

E0010m

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Packing:

96T

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ELISA Kit for Human Connective tissue growth factor

Cat.:

E0010r

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Packing:

96T

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ELISA Kit for Human Connective tissue growth factor

Cat.:

E0010b

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Packing:

96T

ELISA Kit for Human Connective tissue growth factor

Cat.:

E0010p

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Packing:

96T

CLIA Kit for Human Connective tissue growth factor

Cat.:

U0010h

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Manual:

Looking for manual.

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Packing:

96T

Range:

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CLIA Kit for Human Connective tissue growth factor

Cat.:

U0010r

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Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Connective tissue growth factor

Cat.:

U0010m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Connective tissue growth factor

Cat.:

U0010p

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MSDS:

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Packing:

96T

CLIA Kit for Human Connective tissue growth factor

Cat.:

U0010b

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Packing:

96T

Polyclonal Antibody for Human Connective tissue growth factor

Cat.:

P0010Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Connective tissue growth factor

Cat.:

P0010Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Connective tissue growth factor

Cat.:

P0010Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Connective tissue growth factor

Protein for Human Connective tissue growth factor

Cat.:

R0010h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human Connective tissue growth factor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.0%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.8%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of CTGF into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	95-103
Plasma	98	96-101

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CTGF and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	98-105%	100-106%	92-98%	92-103%
EDTA plasma(n=5)	89-98%	93-100%	95-102%	96-103%
heparin plasma(n=5)	99-104%	96-105%	101-108%	92-99%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Hypertrophy of ligamentum flavum in lumbar spine stenosis associated with the increased expression of connective tissue growth factor"

ZM Zhong, DS Zha, WD Xiao, et al.

From:JOURNAL OF ORTHOPAEDIC RESEARCH

References

1.

"Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10."
Bradham D.M. , Igarashi A. , Potter R.L. , Grotendorst G.R.
J. Cell Biol.114:1285-1294(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-83
tissue: Umbilical vein endothelial cell.
2.

"Connective tissue growth factor."
Igarashi A. , Bradham D.M. , Okochi H. , Grotendorst G.R.
J. Dermatol.19:642-643(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-83
tissue: Umbilical vein endothelial cell.
3.

"Human connective tissue growth factor is expressed in advanced atherosclerotic lesions."
Oemar B.S. , Werner A. , Garnier J.-M. , Do D.D. , Godoy N. , Nauck M. , Marz W. , Rupp J. , Pech M. , Luescher T.F.
Circulation95:831-839(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ASP-83
tissue: Aorta.
4.

"Expression, purification and bio-activity of human connective tissue growth factor."
Li Q.-H. , Wang L.-C. , Liu L.-D. , Dong S.-Z. , Wang J.-J. , Hu F. , Wang J. , He S.-Q. , Dong C.-H. , Zhao S.-D. , Zhao H.-L.
Submitted (2003-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-83
5.

"Complete mRNA sequence of human connective tissue growth factor."
Dai W.-J. , Jiang H.-C. , Fu S.-B.
Submitted (2004-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-83
tissue: Liver.
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-83
7.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-83
8.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"Differential expression of novH and CTGF in human glioma cell lines."
Xin L.W. , Martinerie C. , Zumkeller W. , Westphal M. , Perbal B.
Clin. Mol. Pathol.49:91-97(1996)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
tissue: Placenta.
11.

"Identification of human CCN2 (connective tissue growth factor) promoter polymorphisms."
Blom I.E. , van Dijk A.J. , de Weger R.A. , Tilanus M.G.J. , Goldschmeding R.
J. Clin. Pathol.54:192-196(2001)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20
12.

"Connective tissue growth factor mRNA is expressed in human keratinocytes as an immediate early gene that responds to serum, EGF, or wounding."
Cody C.W. , Walker N.J. , Greenlee W.F. , Sutter T.R.
Submitted (1994-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-349;VARIANT ASP-83
13.

"Expression of a gene encoding a novel potential IGF binding protein in human tissues."
Martinerie C. , Perbal B.
C. R. Acad. Sci. III, Sci. Vie313:345-351(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-176 AND 204-225 (ISOFORM 1);TISSUE SPECIFICITY
14.

"Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture."
Nakanishi T. , Nishida T. , Shimo T. , Kobayashi K. , Kubo T. , Tamatani T. , Tezuka K. , Takigawa M.
Endocrinology141:264-273(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
tissue: Chondrocyte.
15.

"The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion."
Ball D.K. , Rachfal A.W. , Kemper S.A. , Brigstock D.R.
J. Endocrinol.176:R1-R7(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEPARIN-BINDING;FUNCTION IN CELL ADHESION

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