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Index > Protein center > EDN1(Gene name) > Human
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  • EDN1 (Gene name),
  • Endothelin-1 (Protein name ),  EDN1_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
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  • Citations  (3)
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  • Feedback
  • Gene name:
    EDN1;
    Protein name:
    Endothelin-1;
    Alternative:
    C-terminal pro endothelin-1(CT-proET1);Preproendothelin-1(PPET1);
    Organism:
    EDN1 (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Endothelins are endothelium-derived vasoconstrictor peptides.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    212
    Sequence:
    50:
    MDYLLMIFSL | LFVACQGAPE | TAVLGAELSA | VGENGGEKPT | PSPPWRLRRS | 
    100:
    KRCSCSSLMD | KECVYFCHLD | IIWVNTPEHV | VPYGLGSPRS | KRALENLLPT | 
    150:
    KATDRENRCQ | CASQKDKKCW | NFCQAGKELR | AEDIMEKDWN | NHKKGKDCSK | 
    200:
    LGKKCIYQQL | VRGRKIRRSS | EEHLRQTRSE | TMRNSVKSSF | HDPKLKGKPS | 
    212:
    RERYVTHNRA | HW
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Endothelin-1
    Cat.:
    E0482h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Endothelin-1
    Cat.:
    E0482r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Endothelin-1
    Cat.:
    E0482m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Endothelin-1
    MSDS:
    Please sign in first.
    ELISA Kit for Human Endothelin-1
    Cat.:
    E0482b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Endothelin-1
    Cat.:
    E0482d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Endothelin-1
    Cat.:
    E0482p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Endothelin-1
    Cat.:
    U0482d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Endothelin-1
    Cat.:
    U0482h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Endothelin-1
    Cat.:
    U0482p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Endothelin-1
    Cat.:
    U0482b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Endothelin-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Endothelin-1
    Cat.:
    U0482m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Endothelin-1
    Cat.:
    U0482r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Endothelin-1
    Polyclonal Antibody for Human Endothelin-1
    Polyclonal Antibody for Human Endothelin-1
    Polyclonal Antibody for Human Endothelin-1
    Polyclonal Antibody for Human Endothelin-1
    Cat.:
    P0482Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Endothelin-1
    Cat.:
    P0482Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Endothelin-1
    Cat.:
    P0482Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Endothelin-1
    Monoclonal Antibody for Human Endothelin-1
    Monoclonal Antibody for Human Endothelin-1
    Monoclonal Antibody for Human Endothelin-1
    Monoclonal Antibody for Human Endothelin-1
    Monoclonal Antibody for Human Endothelin-1
    Monoclonal Antibody for Human Endothelin-1
    Protein for Human Endothelin-1
    Protein for Human Endothelin-1
    Cat.:
    R0482h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Endothelin-1
    Protein for Human Endothelin-1
    Protein for Human Endothelin-1
    Protein for Human Endothelin-1
    Protein for Human Endothelin-1

    R&D Technical Data

    12% SDS-PAGE analysis

                12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin."
      Itoh Y. , Yanagisawa M. , Ohkubo S. , Kimura C. , Kosaka T. , Inoue A. , Ishida N. , Mitsui Y. , Onda H. , Fujino M. , Masaki T.
      FEBS Lett.231:440-444(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    2. 2.
      "The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression."
      Inoue A. , Yanagisawa M. , Takuwa Y. , Mitsui Y. , Kobayashi M. , Masaki T.
      J. Biol. Chem.264:14954-14959(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Structural organization and chromosomal assignment of the gene encoding endothelin."
      Bloch K.D. , Friedrich S.P. , Lee M.E. , Eddy R.L. , Shows T.B. , Quertermous T.
      J. Biol. Chem.264:10851-10857(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Two preproendothelin 1 mRNAs transcribed by alternative promoters."
      Benatti L. , Bonecchi L. , Cozzi L. , Sarmientos P.
      J. Clin. Invest.91:1149-1156(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      NIEHS SNPs program
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ASN-198
    6. 6.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASN-198
      tissue: Pancreas.
    8. 8.
      "The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
      Inoue A. , Yanagisawa M. , Kimura S. , Kasuya Y. , Miyauchi T. , Goto K. , Masaki T.
      Proc. Natl. Acad. Sci. U.S.A.86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-67
    9. 9.
      "Proteolytic processing of big endothelin-3 by the kell blood group protein."
      Lee S. , Lin M. , Mele A. , Cao Y. , Farmar J. , Russo D. , Redman C.
      Blood94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;CLEAVAGE BY KELL;IDENTIFICATION BY MASS SPECTROMETRY
    10. 10.
      "The signal peptide of human preproendothelin-1."
      Fabbrini M.S. , Valsasina B. , Nitti G. , Benatti L. , Vitale A.
      FEBS Lett.286:91-94(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    11. 11.
      "Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
      Bourgeois C. , Robert B. , Rebourcet R. , Mondon F. , Mignot T.-M. , Duc-Goiran P. , Ferre F.
      J. Clin. Endocrinol. Metab.82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    12. 12.
      "Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol."
      Pare G. , Serre D. , Brisson D. , Anand S.S. , Montpetit A. , Tremblay G. , Engert J.C. , Hudson T.J. , Gaudet D.
      Am. J. Hum. Genet.80:673-682(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-198;CHARACTERIZATION OF VARIANT ASN-198
    13. 13.
      "Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease."
      Wiltshire S. , Powell B.L. , Jennens M. , McCaskie P.A. , Carter K.W. , Palmer L.J. , Thompson P.L. , McQuillan B.M. , Hung J. , Beilby J.P.
      Hum. Genet.123:307-313(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-198
    14. 14.
      "Crystallization and preliminary X-ray analysis of human endothelin."
      Wolff M. , Day J. , Greenwood A. , Larson S. , McPherson A.
      Acta Crystallogr. B48:239-240(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF ET-1
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.18 ANGSTROMS) OF ET-1;DISULFIDE BONDS
    16. 16.
      "The conformation of endothelin-1 in aqueous solution: NMR-derived constraints combined with distance geometry and molecular dynamics calculations."
      Reily M.D. , Dunbar J.B. Jr.
      Biochem. Biophys. Res. Commun.178:570-577(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF ET-1
    17. 17.
      "Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis."
      Andersen N.H. , Chen C. , Marschner T.M. , Krystek S.R. Jr. , Bassolino D.A.
      Biochemistry31:1280-1295(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF ET-1
    18. 18.
      "Solution conformation of human big endothelin-1."
      Donlan M.L. , Brown F.K. , Jeffs P.W.
      J. Biomol. NMR2:407-420(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 53-90
    19. 19.
      "A comparison of X-ray and NMR structures for human endothelin-1."
      Wallace B.A. , Janes R.W. , Bassolino D.A. , Krystek S.R. Jr.
      Protein Sci.4:75-83(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COMPARISON OF NMR STRUCTURE WITH X-RAY STRUCTURE
    20. 20.
      "Solution structure of a novel ETB receptor selective agonist ET1-21 [Cys(Acm)1,15, Aib3,11, Leu7] by nuclear magnetic resonance spectroscopy and molecular modelling."
      Hewage C.M. , Jiang L. , Parkinson J.A. , Ramage R. , Sadler I.H.
      J. Pept. Res.53:223-233(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF ET1 AGONIST
    21. 21.
      "The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people."
      Tiret L. , Poirier O. , Hallet V. , McDonagh T.A. , Morrison C. , McMurray J.J. , Dargie H.J. , Arveiler D. , Ruidavets J.B. , Luc G. , Evans A. , Cambien F.
      Hypertension33:1169-1174(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-198
    22. 22.
      "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
      Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-198
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT QME ASP-64;VARIANTS ARCND3 HIS-77 AND GLU-91
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