IL12B Protein for Human(Homo sapiens) | EIAab.comIL12B Protein for Human(Homo sapiens)

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Index > Protein center > IL12B(Gene name) > Human

IL12B (Gene name),

Interleukin-12 subunit beta (Protein name ), IL12B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

IL12B(NKSF2);

Protein name:

Interleukin-12 subunit beta(IL-12B);

Alternative:

IL-12 subunit p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit(CLMF p40);NK cell stimulatory factor chain 2(NKSF2);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.

Function:

Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

328

Sequence:

50:

100:

150:

200:

250:

300:

328:

RKNASISVRA | QDRYYSSSWS | EWASVPCS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.674

MIM:

161561

KEGG:

hsa:3593

STRING:

9606.ENSP00000231228

String:

P29460

Pfam:

PF10420

SMR:

P29460

Uniprot:

P29460

FOR

ELISA Kit for Human IL-12B

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E0058p

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96T

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ELISA Kit for Human IL-12B

Cat.:

E0058m

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96T

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ELISA Kit for Human IL-12B

Cat.:

E0058d

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96T

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ELISA Kit for Human IL-12B

Cat.:

E0058b

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96T

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ELISA Kit for Human IL-12B

Cat.:

E0058h

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96T

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CLIA Kit for Human IL-12B

Cat.:

U0058h

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96T

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CLIA Kit for Human IL-12B

Cat.:

U0058b

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human IL-12B

Cat.:

U0058m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human IL-12B

Cat.:

U0058p

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human IL-12B

Cat.:

U0058d

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96T

Polyclonal Antibody for Human IL-12B

Cat.:

P0058Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human IL-12B

Cat.:

P0058Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human IL-12B

Protein for Human IL-12B

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor."
Gubler U. , Chua A.O. , Schoenhaut D.S. , Dwyer C.M. , McComas W. , Motyka R. , Nabavi N. , Wolitzky A.G. , Quinn P.M. , Familletti P.C. , Gately M.K.
Proc. Natl. Acad. Sci. U.S.A.88:4143-4147(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells."
Wolf S.F. , Temple P.A. , Kobayashi M. , Young D. , Dicig M. , Lowe L. , Dzialo R. , Fitz L. , Ferenz C. , Hewick R.M. , Kelleher K. , Herrmann S.H. , Clark S.C. , Azzoni L. , Chan S.H. , Trinchieri G. , Perussia B.
J. Immunol.146:3074-3081(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Complete primary structure, chromosomal localization, and definition of polymorphisms of the gene encoding the human interleukin 12 p40 subunit."
Huang D. , Cancilla M.R. , Morahan G.
Genes Immun.1:515-520(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Cloning and sequence analysis of IL-12 cDNA from Chinese."
Hongyuan J. , Meiyun Z.
Submitted (1999-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

SeattleSNPs variation discovery resource
Submitted (2002-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-33 AND PHE-298
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
7.

"Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells."
Stern A.S. , Podlaski F.J. , Hulmes J.D. , Pan Y.C.E. , Quinn P.M. , Wolitzky A.G. , Familletti P.C. , Stremlo D.L. , Truitt T. , Chizzonite R. , Gately M.K.
Proc. Natl. Acad. Sci. U.S.A.87:6808-6812(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-45
8.

"Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor."
Gearing D.P. , Cosman D.
Cell66:9-10(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIMILARITY TO IL-6 RECEPTOR
9.

"Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production."
D'Andrea A. , Ma X. , Aste-Amezaga M. , Paganin C. , Trinchieri G.
J. Exp. Med.181:537-546(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
10.

"Recombinant human interleukin-12 is the second example of a C-mannosylated protein."
Doucey M.A. , Hess D. , Blommers M.J. , Hofsteenge J.
Glycobiology9:435-441(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-319
11.

"Inherited interleukin 12 deficiency in a child with bacille Calmette-Guerin and Salmonella enteritidis disseminated infection."
Altare F. , Lammas D. , Revy P. , Jouanguy E. , Doeffinger R. , Lamhamedi-Cherradi S.-E. , Drysdale P. , Scheel-Toellner D. , Girdlestone J. , Darbyshire P. , Wadhwa M. , Dockrell H. , Salmon M. , Fischer A. , Durandy A. , Casanova J.-L. , Kumararatne D.S.
J. Clin. Invest.102:2035-2040(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IMD29
12.

"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
Oppmann B. , Lesley R. , Blom B. , Timans J.C. , Xu Y. , Hunte B. , Vega F. , Yu N. , Wang J. , Singh K.P. , Zonin F. , Vaisberg E. , Churakova T. , Liu M.-R. , Gorman D. , Wagner J. , Zurawski S. , Liu Y.-J. , more...
Immunity13:715-725(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IL23A
13.

"Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds."
Picard C. , Fieschi C. , Altare F. , Al-Jumaah S. , Al-Hajjar S. , Feinberg J. , Dupuis S. , Soudais C. , Al-Mohsen I.Z. , Genin E. , Lammas D. , Kumararatne D.S. , Leclerc T. , Rafii A. , Frayha H. , Murugasu B. , Wah L.B. , Sinniah R. , more...
Am. J. Hum. Genet.70:336-348(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IMD29
14.

"Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."
Capon F. , Di Meglio P. , Szaub J. , Prescott N.J. , Dunster C. , Baumber L. , Timms K. , Gutin A. , Abkevic V. , Burden A.D. , Lanchbury J. , Barker J.N. , Trembath R.C. , Nestle F.O.
Hum. Genet.122:201-206(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH PSORIASIS
15.

"Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."
Huffmeier U. , Lascorz J. , Bohm B. , Lohmann J. , Wendler J. , Mossner R. , Reich K. , Traupe H. , Kurrat W. , Burkhardt H. , Reis A.
J. Invest. Dermatol.129:355-358(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH PSORIASIS
16.

"Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12."
Yoon C. , Johnston S.C. , Tang J. , Stahl M. , Tobin J.F. , Somers W.S.
EMBO J.19:3530-3541(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-328 ALONE AND IN COMPLEX WITH IL12A;GLYCOSYLATION AT ASN-222;DISULFIDE BONDS
17.

"Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody."
Beyer B.M. , Ingram R. , Ramanathan L. , Reichert P. , Le H.V. , Madison V. , Orth P.
J. Mol. Biol.382:942-955(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-328 IN COMPLEX WITH IL23A AND ANTIBODY
18.

"The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12."
Lupardus P.J. , Garcia K.C.
J. Mol. Biol.382:931-941(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 23-328 IN COMPLEX WITH IL23A;SUBUNIT

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