Protein name:
Interleukin-12 subunit beta (IL-12B) ;
Alternative:
IL-12 subunit p40 ;Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
Function:
Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Subcellular Location:
Secreted
Protein Attributes:
50:
MCPQKLTISW | FAIVLLVSPL | MAMWELEKDV | YVVEVDWTPD | APGETVNLTC |
100:
DTPEEDDITW | TSDQRHGVIG | SGKTLTITVK | EFLDAGQYTC | HKGGETLSHS |
150:
HLLLHKKENG | IWSTEILKNF | KNKTFLKCEA | PNYSGRFTCS | WLVQRNMDLK |
200:
FNIKSSSSSP | DSRAVTCGMA | SLSAEKVTLD | QRDYEKYSVS | CQEDVTCPTA |
250:
EETLPIELAL | EARQQNKYEN | YSTSFFIRDI | IKPDPPKNLQ | MKPLKNSQVE |
300:
VSWEYPDSWS | TPHSYFSLKF | FVRIQRKKEK | MKETEEGCNQ | KGAFLVEKTS |
335:
TEVQCKGGNV | CVQAQDRYYN | SSCSKWACVP | CRVRS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Mouse
Dog
Bovine
Human
ELISA Kit for Mouse IL-12B
ELISA Kit for Mouse IL-12B
ELISA Kit for Mouse IL-12B
ELISA Kit for Mouse IL-12B
ELISA Kit for Mouse IL-12B
CLIA Kit for Mouse IL-12B
CLIA Kit for Mouse IL-12B
CLIA Kit for Mouse IL-12B
CLIA Kit for Mouse IL-12B
CLIA Kit for Mouse IL-12B
Polyclonal Antibody for Mouse IL-12B
Polyclonal Antibody for Mouse IL-12B
Polyclonal Antibody for Mouse IL-12B
Polyclonal Antibody for Mouse IL-12B
Polyclonal Antibody for Mouse IL-12B
Monoclonal Antibody for Mouse IL-12B
Monoclonal Antibody for Mouse IL-12B
Monoclonal Antibody for Mouse IL-12B
Monoclonal Antibody for Mouse IL-12B
Monoclonal Antibody for Mouse IL-12B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6 .
tissue :
Spleen .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];VARIANTS THR-169 AND LEU-294
strain :
B10.S/J .
strain :
SJL/J .
tissue :
Spleen .
4.
"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
Oppmann B.
,
Lesley R.
,
Blom B.
,
Timans J.C.
,
Xu Y.
,
Hunte B.
,
Vega F.
,
Yu N.
,
Wang J.
,
Singh K.P.
,
Zonin F.
,
Vaisberg E.
,
Churakova T.
,
Liu M.-R.
,
Gorman D.
,
Wagner J.
,
Zurawski S.
,
Liu Y.-J.
,
Abrams J.S.
,
Moore K.W.
,
Rennick D.M.
,
de Waal-Malefyt R.
,
Hannum C.
,
Bazan J.F.
,
Kastelein R.A.
more...
Immunity13:715-725(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH IL23A