KIF5A Protein for Human(Homo sapiens) | EIAab.comKIF5A Protein for Human(Homo sapiens)

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KIF5A (Gene name),

Kinesin heavy chain isoform 5A (Protein name ), KIF5A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KIF5A(NKHC1);

Protein name:

Kinesin heavy chain isoform 5A;

Alternative:

Neuronal kinesin heavy chain(NKHC);Kinesin heavy chain neuron-specific 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1.

Function:

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL).

Subcellular Location:

Cytoplasm perinuclear region Cytoplasm cytoskeleton Concentrated in the cell body of the neurons, particularly in the perinuclear region.

Protein Attributes:

Sequence length:

1032

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1032:

TDINDNRSDL | PCGYEAEDQA | KLFPLHQETA | AS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.151219

String:

Q12840

Pfam:

PF00225

STRING:

9606.ENSP00000286452

MIM:

602821

SMR:

Q12840

KEGG:

hsa:3798

Uniprot:

Q12840

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ELISA Kit for Human Kinesin heavy chain isoform 5A

Cat.:

E0155h

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Packing:

96T

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ELISA Kit for Human Kinesin heavy chain isoform 5A

Cat.:

E0155r

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MSDS:

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Packing:

96T

ELISA Kit for Human Kinesin heavy chain isoform 5A

Cat.:

E0155m

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MSDS:

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Packing:

96T

CLIA Kit for Human Kinesin heavy chain isoform 5A

Cat.:

U0155h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human Kinesin heavy chain isoform 5A

Cat.:

U0155m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Kinesin heavy chain isoform 5A

Cat.:

U0155r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Kinesin heavy chain isoform 5A

Cat.:

P0155Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Kinesin heavy chain isoform 5A

Cat.:

P0155Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Kinesin heavy chain isoform 5A

Cat.:

P0155Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Kinesin heavy chain isoform 5A

Protein for Human Kinesin heavy chain isoform 5A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and localization of a conventional kinesin motor expressed exclusively in neurons."
Niclas J. , Navone F. , Hom-Booher N. , Vale R.D.
Neuron12:1059-1072(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hippocampus.
2.

"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
Nakajima D. , Saito K. , Yamakawa H. , Kikuno R.F. , Nakayama M. , Ohara R. , Okazaki N. , Koga H. , Nagase T. , Ohara O.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
6.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
7.

"A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)."
Reid E. , Kloos M. , Ashley-Koch A. , Hughes L. , Bevan S. , Svenson I.K. , Graham F.L. , Gaskell P.C. , Dearlove A. , Pericak-Vance M.A. , Rubinsztein D.C. , Marchuk D.A.
Am. J. Hum. Genet.71:1189-1194(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SPG10 SER-256
8.

"Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia."
Fichera M. , Lo Giudice M. , Falco M. , Sturnio M. , Amata S. , Calabrese O. , Bigoni S. , Calzolari E. , Neri M.
Neurology63:1108-1110(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SPG10 CYS-280
9.

"A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia."
Lo Giudice M. , Neri M. , Falco M. , Sturnio M. , Calzolari E. , Di Benedetto D. , Fichera M.
Arch. Neurol.63:284-287(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SPG10 VAL-361
10.

"Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia."
Blair M.A. , Ma S. , Hedera P.
Neurogenetics7:47-50(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SPG10 CYS-276
11.

"Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity."
Ebbing B. , Mann K. , Starosta A. , Jaud J. , Schoels L. , Schuele R. , Woehlke G.
Hum. Mol. Genet.17:1245-1252(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-253;CHARACTERIZATION OF VARIANT ASN-253;CHARACTERIZATION OF VARIANTS SPG10 SER-256 AND VAL-361;MUTAGENESIS OF ARG-280
12.

"SPG10 is a rare cause of spastic paraplegia in European families."
Schuele R. , Kremer B.P.H. , Kassubek J. , Auer-Grumbach M. , Kostic V. , Klopstock T. , Klimpe S. , Otto S. , Boesch S. , van de Warrenburg B.P. , Schoels L.
J. Neurol. Neurosurg. Psych.79:584-587(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SPG10 ASN-253 AND ASN-256 DEL
13.

"Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10."
Goizet C. , Boukhris A. , Mundwiller E. , Tallaksen C. , Forlani S. , Toutain A. , Carriere N. , Paquis V. , Depienne C. , Durr A. , Stevanin G. , Brice A.
Hum. Mutat.30:E376-E385(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SPG10 CYS-63; THR-198; GLN-204; LYS-251; ASN-257; CYS-280; LEU-280 AND HIS-280
14.

"A novel mutation in KIF5A gene causing hereditary spastic paraplegia with axonal neuropathy."
Musumeci O. , Bassi M.T. , Mazzeo A. , Grandis M. , Crimella C. , Martinuzzi A. , Toscano A.
Neurol. Sci.32:665-668(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SPG10 CYS-203

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