TNFRSF1B Protein for Human(Homo sapiens) | EIAab.comTNFRSF1B Protein for Human(Homo sapiens)

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TNFRSF1B (Gene name),

Tumor necrosis factor receptor superfamily member 1B (Protein name ), TNR1B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

TNFRSF1B(TNFBR;TNFR2);

Protein name:

Tumor necrosis factor receptor superfamily member 1B;

Alternative:

Tumor necrosis factor receptor type II(TNF-RII;TNFR-II);Tumor necrosis factor receptor 2(TNF-R2);p80 TNF-alpha receptor;p75;

CD:

CD120b;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to TRAF2. Interacts with BMX.

Function:

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Subcellular Location:

Tumor necrosis factor-binding protein 2 Secreted

Protein Attributes:

Sequence length:

461

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

461:

LGVPDAGMKP | S

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:7133

SMR:

P20333

MIM:

191191

UniGene:

Hs.256278

STRING:

9606.ENSP00000365435

String:

P20333

Pfam:

PF00020

Uniprot:

P20333

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

E0132h

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96T

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

E0132m

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96T

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

E0132r

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96T

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CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

U0132h

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96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

U0132m

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96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

U0132r

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96T

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

P0132Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B

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P0132Rb-m

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Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

P0132Rb-h

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Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B

Protein for Human Tumor necrosis factor receptor superfamily member 1B

Cat.:

R0132h

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Increased Serum Concentrations of Circulating Glycocalyx Components in HELLP Syndrome Compared to Healthy Pregnancy: An Observational Study"

Klaus F. Hofmann-Kiefer, D. Chappell, J. Knabl,H.G. Frank, N. Martinoff, P. Conzen, B.F. Becker, M. Rehm

From:Reproductive Sciences

[2].

"Demethylation of tumor necrosis factor-α converting enzyme predicts poor prognosis in acute-on-chronic hepatitis B liver failure"

Wang Z L, Gao S, Li L, et al

From:Clinics and research in hepatology and gastroenterology

References

1.

"A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor."
Kohno T. , Brewer M.T. , Baker S.L. , Schwartz P.E. , King M.W. , Hale K.K. , Squires C.H. , Thompson R.C. , Vannice J.L.
Proc. Natl. Acad. Sci. U.S.A.87:8331-8335(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-196
2.

"A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins."
Smith C.A. , Davis T. , Anderson D. , Solam L. , Beckmann M.P. , Jerzy R. , Dower S.K. , Cosman D. , Goodwin R.G.
Science248:1019-1023(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Physical mapping and genomic structure of the human TNFR2 gene."
Beltinger C.P. , White P.S. , Maris J.M. , Sulman E.P. , Jensen S.J. , Lepaslier D. , Stallard B.J. , Goeddel D.V. , Desauvage F.J. , Brodeur G.M.
Genomics35:94-100(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
4.

"Identification and characterization of a novel spliced variant that encodes human soluble tumor necrosis factor receptor 2."
Lainez B. , Fernandez-Real J.M. , Romero X. , Esplugues E. , Canete J.D. , Ricart W. , Engel P.
Int. Immunol.16:169-177(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);SUBCELLULAR LOCATION;FUNCTION (ISOFORM 2)
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

NIEHS SNPs program
Submitted (2003-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-187; ARG-196; LYS-232; THR-236; PRO-264 AND ARG-295
7.

SeattleSNPs variation discovery resource
Submitted (2003-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-196; LYS-232; PRO-269 AND ARG-301
8.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: PNS.
11.

"Purification and partial amino acid sequence analysis of two distinct tumor necrosis factor receptors from HL60 cells."
Loetscher H. , Schlaeger E.J. , Lahm H.-W. , Pan Y.-C.E. , Lesslauer W. , Brockhaus M.
J. Biol. Chem.265:20131-20138(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-40; 65-69; 136-141; 300-306 AND 346-362
12.

"Purification of two types of TNF inhibitors in the urine of the patient with chronic glomerulonephritis."
Suzuki J. , Tomizawa S. , Arai H. , Seki Y. , Maruyama K. , Kuroume T.
Nephron66:386-390(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-37
tissue: Urine.
13.

"Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors."
Engelmann H. , Novick D. , Wallach D.
J. Biol. Chem.265:1531-1536(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-31
tissue: Urine.
14.

"Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences."
Dembic Z. , Loetscher H. , Gubler U. , Pan Y.C. , Lahm H.-W. , Gentz R. , Brockhaus M. , Lesslauer W.
Cytokine2:231-237(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-461 (ISOFORM 1)
15.

"Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor."
Heller R.A. , Song K. , Onasch M.A. , Fischer W.H. , Chang D. , Ringold G.M.
Proc. Natl. Acad. Sci. U.S.A.87:6151-6155(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 116-461 (ISOFORM 1);PARTIAL PROTEIN SEQUENCE;VARIANT ARG-196
16.

"New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosus."
Tsuchiya N. , Komata T. , Matsushita M. , Ohashi J. , Tokunaga K.
Genes Immun.1:501-503(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 154-183;VARIANTS ARG-196 AND LYS-232
17.

"Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation."
Pennica D. , Lam V.T. , Mize N.K. , Weber R.F. , Lewis M. , Fendly B.M. , Lipari M.T. , Goeddel D.V.
J. Biol. Chem.267:21172-21178(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
18.

"A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor."
Rothe M. , Wong S.C. , Henzel W.J. , Goeddel D.V.
Cell78:681-692(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF2
19.

"Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis."
Pan S. , An P. , Zhang R. , He X. , Yin G. , Min W.
Mol. Cell. Biol.22:7512-7523(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BMX
20.

"Structural basis for self-association and receptor recognition of human TRAF2."
Park Y.C. , Burkitt V. , Villa A.R. , Tong L. , Wu H.
Nature398:533-538(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 419-428 IN COMPLEX WITH TRAF2
21.

"Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese: molecular and functional analysis."
Morita C. , Horiuchi T. , Tsukamoto H. , Hatta N. , Kikuchi Y. , Arinobu Y. , Otsuka T. , Sawabe T. , Harashima S. , Nagasawa K. , Niho Y.
Arthritis Rheum.44:2819-2827(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-196 AND LYS-232
22.

"Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism."
Peral B. , San Millan J.L. , Castello R. , Moghetti P. , Escobar-Morreale H.F.
J. Clin. Endocrinol. Metab.87:3977-3983(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-196

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