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Index > Protein center > FLT1(Gene name) > Human
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  • FLT1 (Gene name),
  • Vascular endothelial growth factor receptor 1 (Protein name ),  VGFR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    FLT1(FLT;FRT;VEGFR1);
    Protein name:
    Vascular endothelial growth factor receptor 1(VEGFR-1);
    Alternative:
    Tyrosine-protein kinase FRT;Fms-like tyrosine kinase 1(FLT-1);Vascular permeability factor receptor;Tyrosine-protein kinase receptor FLT(FLT);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts in vitro with various phosphotyrosine-binding proteins, including PLC-gammas, PTPN11, GRB2, CRK and NCK1. Interacts with GNB2L1/RACK1.
    Function:
    Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform 2 and isoform 3 may have an inhibitory role in angiogenesis.
    Subcellular Location:
    Isoform 3 Secreted
    Protein Attributes:
    Sequence length:
    1338
    Sequence:
    50:
    MVSYWDTGVL | LCALLSCLLL | TGSSSGSKLK | DPELSLKGTQ | HIMQAGQTLH | 
    100:
    LQCRGEAAHK | WSLPEMVSKE | SERLSITKSA | CGRNGKQFCS | TLTLNTAQAN | 
    150:
    HTGFYSCKYL | AVPTSKKKET | ESAIYIFISD | TGRPFVEMYS | EIPEIIHMTE | 
    200:
    GRELVIPCRV | TSPNITVTLK | KFPLDTLIPD | GKRIIWDSRK | GFIISNATYK | 
    250:
    EIGLLTCEAT | VNGHLYKTNY | LTHRQTNTII | DVQISTPRPV | KLLRGHTLVL | 
    300:
    NCTATTPLNT | RVQMTWSYPD | EKNKRASVRR | RIDQSNSHAN | IFYSVLTIDK | 
    350:
    MQNKDKGLYT | CRVRSGPSFK | SVNTSVHIYD | KAFITVKHRK | QQVLETVAGK | 
    400:
    RSYRLSMKVK | AFPSPEVVWL | KDGLPATEKS | ARYLTRGYSL | IIKDVTEEDA | 
    450:
    GNYTILLSIK | QSNVFKNLTA | TLIVNVKPQI | YEKAVSSFPD | PALYPLGSRQ | 
    500:
    ILTCTAYGIP | QPTIKWFWHP | CNHNHSEARC | DFCSNNEESF | ILDADSNMGN | 
    550:
    RIESITQRMA | IIEGKNKMAS | TLVVADSRIS | GIYICIASNK | VGTVGRNISF | 
    600:
    YITDVPNGFH | VNLEKMPTEG | EDLKLSCTVN | KFLYRDVTWI | LLRTVNNRTM | 
    650:
    HYSISKQKMA | ITKEHSITLN | LTIMNVSLQD | SGTYACRARN | VYTGEEILQK | 
    700:
    KEITIRDQEA | PYLLRNLSDH | TVAISSSTTL | DCHANGVPEP | QITWFKNNHK | 
    750:
    IQQEPGIILG | PGSSTLFIER | VTEEDEGVYH | CKATNQKGSV | ESSAYLTVQG | 
    800:
    TSDKSNLELI | TLTCTCVAAT | LFWLLLTLFI | RKMKRSSSEI | KTDYLSIIMD | 
    850:
    PDEVPLDEQC | ERLPYDASKW | EFARERLKLG | KSLGRGAFGK | VVQASAFGIK | 
    900:
    KSPTCRTVAV | KMLKEGATAS | EYKALMTELK | ILTHIGHHLN | VVNLLGACTK | 
    950:
    QGGPLMVIVE | YCKYGNLSNY | LKSKRDLFFL | NKDAALHMEP | KKEKMEPGLE | 
    1000:
    QGKKPRLDSV | TSSESFASSG | FQEDKSLSDV | EEEEDSDGFY | KEPITMEDLI | 
    1050:
    SYSFQVARGM | EFLSSRKCIH | RDLAARNILL | SENNVVKICD | FGLARDIYKN | 
    1100:
    PDYVRKGDTR | LPLKWMAPES | IFDKIYSTKS | DVWSYGVLLW | EIFSLGGSPY | 
    1150:
    PGVQMDEDFC | SRLREGMRMR | APEYSTPEIY | QIMLDCWHRD | PKERPRFAEL | 
    1200:
    VEKLGDLLQA | NVQQDGKDYI | PINAILTGNS | GFTYSTPAFS | EDFFKESISA | 
    1250:
    PKFNSGSSDD | VRYVNAFKFM | SLERIKTFEE | LLPNATSMFD | DYQGDSSTLL | 
    1300:
    ASPMLKRFTW | TDSKPKASLK | IDLRVTSKSK | ESGLSDVSRP | SFCHSSCGHV | 
    1338:
    SEGKRRFTYD | HAELERKIAC | CSPPPDYNSV | VLYSTPPI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human VEGFR-1
    Cat.:
    E0147m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human VEGFR-1
    Cat.:
    E0147r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human VEGFR-1
    Cat.:
    E0147h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human VEGFR-1
    Cat.:
    E0147c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human VEGFR-1
    Cat.:
    U0147h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human VEGFR-1
    Cat.:
    U0147m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human VEGFR-1
    Cat.:
    U0147r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human VEGFR-1
    Cat.:
    U0147c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human VEGFR-1
    Polyclonal Antibody for Human VEGFR-1
    Cat.:
    P0147Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VEGFR-1
    Cat.:
    P0147Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human VEGFR-1
    Cat.:
    P0147Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human VEGFR-1
    Monoclonal Antibody for Human VEGFR-1
    Monoclonal Antibody for Human VEGFR-1
    Monoclonal Antibody for Human VEGFR-1
    Protein for Human VEGFR-1
    Protein for Human VEGFR-1
    Protein for Human VEGFR-1
    Protein for Human VEGFR-1

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    References
    1. 1.
      "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family."
      Shibuya M. , Yamaguchi S. , Yamane A. , Ikeda T. , Tojo A. , Matsushime H. , Sato M.
      Oncogene5:519-524(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    2. 2.
      "Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor."
      Kendall R.L. , Thomas K.A.
      Proc. Natl. Acad. Sci. U.S.A.90:10705-10709(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);PROTEIN SEQUENCE OF N-TERMINUS;SUBCELLULAR LOCATION (ISOFORM 2);INTERACTION WITH VEGFA;FUNCTION
      tissue: Umbilical vein.
    3. 3.
      "Characterization of the VEGF binding site on the Flt-1 receptor."
      Herley M.T. , Yu Y. , Whitney R.G. , Sato J.D.
      Biochem. Biophys. Res. Commun.262:731-738(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VEGFA;GLYCOSYLATION
      tissue: Umbilical vein.
    4. 4.
      "Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis."
      Jin P. , Zhang J. , Sumariwalla P.F. , Ni I. , Jorgensen B. , Crawford D. , Phillips S. , Feldmann M. , Shepard H.M. , Paleolog E.M.
      Arthritis Res. Ther.10:R73-R73(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);FUNCTION IN LIGAND BINDING;SUBCELLULAR LOCATION
    5. 5.
      "A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia."
      Sela S. , Itin A. , Natanson-Yaron S. , Greenfield C. , Goldman-Wohl D. , Yagel S. , Keshet E.
      Circ. Res.102:1566-1574(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;ROLE IN PREECLAMPSIA;INDUCTION
    6. 6.
      "A novel intracellular isoform of VEGFR-1 activates Src and promotes cell invasion in MDA-MB-231 breast cancer cells."
      Mezquita B. , Mezquita J. , Pau M. , Mezquita C.
      J. Cell. Biochem.110:732-742(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7 AND 8);ALTERNATIVE SPLICING;FUNCTION IN PHOSPHORYLATION OF SRC AND CANCER CELL INVASIVENESS;TISSUE SPECIFICITY
    7. 7.
      "A new VEGFR1 receptor transcript coding for the extracellular domains of the protein followed by a C-terminal polyserine tail."
      Mezquita J. , Mezquita B. , Pau M. , Mezquita C.
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    8. 8.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Placenta.
      tissue: Trachea.
    10. 10.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Ovary.
    13. 13.
      "A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13."
      Matsushime H. , Yoshida M.C. , Sasaki M. , Shibuya M.
      Jpn. J. Cancer Res.78:655-661(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1018-1058;ALTERNATIVE SPLICING (ISOFORM 1)
    14. 14.
      "Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules."
      Ito N. , Wernstedt C. , Engstrom U. , Claesson-Welsh L.
      J. Biol. Chem.273:23410-23418(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-914; TYR-1213; TYR-1242; TYR-1327 AND TYR-1333;MUTAGENESIS OF TYR-914; TYR-1213; TYR-1242; TYR-1327 AND TYR-1333;INTERACTION WITH PLCG; GRB2; CRK; NCK1 AND PTPN11
    15. 15.
      "A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF."
      Seetharam L. , Gotoh N. , Maru Y. , Neufeld G. , Yamaguchi S. , Shibuya M.
      Oncogene10:135-147(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VEGFA;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;FUNCTION IN PHOSPHORYLATION OF PLCG;ABSENCE OF MITOGENIC FUNCTION IN CULTURED FIBROBLASTS
    16. 16.
      "Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1."
      Barleon B. , Sozzani S. , Zhou D. , Weich H.A. , Mantovani A. , Marme D.
      Blood87:3336-3343(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION;FUNCTION IN VEGFA AND PGF SIGNALING;INDUCTION
    17. 17.
      "The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCgamma."
      Sawano A. , Takahashi T. , Yamaguchi S. , Shibuya M.
      Biochem. Biophys. Res. Commun.238:487-491(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PLCG AND ACTIVATION OF MAP KINASES;INTERACTION WITH PLCG;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-861 AND TYR-1169;PHOSPHORYLATION AT TYR-1169 AND TYR-1213
    18. 18.
      "Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2."
      Igarashi K. , Isohara T. , Kato T. , Shigeta K. , Yamano T. , Uno I.
      Biochem. Biophys. Res. Commun.246:95-99(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1; PTPN11 AND NCK1;PHOSPHORYLATION AT TYR-1213
    19. 19.
      "Vascular endothelial growth factor receptor-2-mediated mitogenesis is negatively regulated by vascular endothelial growth factor receptor-1 in tumor epithelial cells."
      Dunk C. , Ahmed A.
      Am. J. Pathol.158:265-273(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS NEGATIVE REGULATOR OF KDR-MEDIATED CELL PROLIFERATION
    20. 20.
      "Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding."
      Yu Y. , Hulmes J.D. , Herley M.T. , Whitney R.G. , Crabb J.W. , Sato J.D.
      Biochem. J.358:465-472(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIK3R1 AND VEGFA;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-1213;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;GLYCOSYLATION
    21. 21.
      "Effect of placenta growth factor-1 on proliferation and release of nitric oxide, cyclic AMP and cyclic GMP in human epithelial cells expressing the FLT-1 receptor."
      Angelucci C. , Lama G. , Iacopino F. , Maglione D. , Sica G.
      Growth Factors19:193-206(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PGF-MEDIATED CHORIOCARCINOMA CELL PROLIFERATION
    22. 22.
      "Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers."
      Huang K. , Andersson C. , Roomans G.M. , Ito N. , Claesson-Welsh L.
      Int. J. Biochem. Cell Biol.33:315-324(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDR;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION;FUNCTION IN VEGFA SIGNALING; PHOSPHORYLATION OF PLCG AND ACTIVATION OF PHOSPHATIDYLINOSITOL KINASE AND PHOSPHOLIPASE C
    23. 23.
      "Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells."
      Cai J. , Ahmad S. , Jiang W.G. , Huang J. , Kontos C.D. , Boulton M. , Ahmed A.
      Diabetes52:2959-2968(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SIGNALING VIA ACTIVATION OF THE PHOSPHATIDYLINOSITOL KINASE PATHWAY AND POSITIVE REGULATION OF ANGIOGENESIS IN RESPONSE TO PGF AND VEGFA
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PGF AND KDR;FUNCTION IN PHOSPHORYLATION OF KDR; VEGFA AND PGF SIGNALING;CATALYTIC ACTIVITY;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-1213; TYR-1327 AND TYR-1309
    25. 25.
      "The c-Cbl/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1)."
      Kobayashi S. , Sawano A. , Nojima Y. , Shibuya M. , Maru Y.
      FASEB J.18:929-931(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL AND CD2AP;UBIQUITINATION;AUTOPHOSPHORYLATION IN RESPONSE TO VEGFA;MUTAGENESIS OF TYR-1333;SUBCELLULAR LOCATION
    26. 26.
      "Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells."
      Fan F. , Wey J.S. , McCarty M.F. , Belcheva A. , Liu W. , Bauer T.W. , Somcio R.J. , Wu Y. , Hooper A. , Hicklin D.J. , Ellis L.M.
      Oncogene24:2647-2653(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VEGFA AND VEGFB SIGNALING; CANCER CELL MIGRATION; INVASIVENESS AND ACTIVATION OF MAPK1/ERK2 AND MAPK3/ERK1
    27. 27.
      "Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases."
      Lesslie D.P. , Summy J.M. , Parikh N.U. , Fan F. , Trevino J.G. , Sawyer T.K. , Metcalf C.A. , Shakespeare W.C. , Hicklin D.J. , Ellis L.M. , Gallick G.E.
      Br. J. Cancer94:1710-1717(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL MIGRATION AND PHOSPHORYLATION OF PTK2/FAK1; YES1 AND SRC
    28. 28.
      "A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1."
      Meyer R.D. , Mohammadi M. , Rahimi N.
      J. Biol. Chem.281:867-875(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASN-1050
    29. 29.
      "The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes."
      Tchaikovski V. , Fellbrich G. , Waltenberger J.
      Arterioscler. Thromb. Vasc. Biol.28:322-328(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PGF AND VEGFA SIGNALING; PHOSPHORYLATION OF AKT1; MAPK3/ERK1 AND MAP KINASES; CHEMOTAXIS AND ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE;AUTOPHOSPHORYLATION IN RESPONSE TO PGF AND VEGFA
    30. 30.
      "Vascular endothelial growth factor receptor-1 regulates postnatal angiogenesis through inhibition of the excessive activation of Akt."
      Nishi J. , Minamino T. , Miyauchi H. , Nojima A. , Tateno K. , Okada S. , Orimo M. , Moriya J. , Fong G.H. , Sunagawa K. , Shibuya M. , Komuro I.
      Circ. Res.103:261-268(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ENDOTHELIAL CELL SURVIVAL AND ANGIOGENESIS
    31. 31.
      "Placental growth factor (PlGF) enhances breast cancer cell motility by mobilising ERK1/2 phosphorylation and cytoskeletal rearrangement."
      Taylor A.P. , Leon E. , Goldenberg D.M.
      Br. J. Cancer103:82-89(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CANCER CELL MIGRATION AND ACTIVATION OF MAPK1/ERK2 AND/OR MAPK3/ERK1
    32. 32.
      "RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3-K/Akt pathway."
      Wang F. , Yamauchi M. , Muramatsu M. , Osawa T. , Tsuchida R. , Shibuya M.
      J. Biol. Chem.286:9097-9106(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNB2L1
    33. 33.
      "gamma-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1."
      Cai J. , Chen Z. , Ruan Q. , Han S. , Liu L. , Qi X. , Boye S.L. , Hauswirth W.W. , Grant M.B. , Boulton M.E.
      J. Biol. Chem.286:42514-42523(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSEN1 AND PTPRB;DEPHOSPHORYLATION BY PTPRB;MUTAGENESIS OF VAL-767;PROTEOLYTIC CLEAVAGE BY PSEN1 AT VAL-767
    34. 34.
      "Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis."
      Ahmad S. , Hewett P.W. , Al-Ani B. , Sissaoui S. , Fujisawa T. , Cudmore M.J. , Ahmed A.
      Vasc. Cell3:15-15(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DECOY RECEPTORS; REGULATION OF VEGFA SIGNALING AND REGULATION OF KDR ACTIVITY (ISOFORMS 2/3/4);ROLE IN PREECLAMPSIA
    35. 35.
      "Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis."
      Shibuya M.
      J. Biochem. Mol. Biol.39:469-478(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION AS NEGATIVE REGULATOR OF ANGIOGENESIS DURING EMBRYONIC DEVELOPMENT; POSITIVE REGULATION OF MACROPHAGE FUNCTION IN ADULTHOOD; ROLE IN CARCINOGENESIS AND INFLAMMATION
    36. 36.
      "VEGF receptor protein-tyrosine kinases: structure and regulation."
      Roskoski R. Jr.
      Biochem. Biophys. Res. Commun.375:287-291(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON STRUCTURE AND FUNCTION
    37. 37.
      "VEGFs and receptors involved in angiogenesis versus lymphangiogenesis."
      Lohela M. , Bry M. , Tammela T. , Alitalo K.
      Curr. Opin. Cell Biol.21:154-165(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN ANGIOGENESIS AND CANCER
    38. 38.
      "Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling."
      Grunewald F.S. , Prota A.E. , Giese A. , Ballmer-Hofer K.
      Biochim. Biophys. Acta1804:567-580(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
    39. 39.
      "Vascular endothelial growth factor receptor-1 in human cancer: concise review and rationale for development of IMC-18F1 (Human antibody targeting vascular endothelial growth factor receptor-1)."
      Schwartz J.D. , Rowinsky E.K. , Youssoufian H. , Pytowski B. , Wu Y.
      Cancer116:1027-1032(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN CANCER
    40. 40.
      "Signal transduction by vascular endothelial growth factor receptors."
      Koch S. , Tugues S. , Li X. , Gualandi L. , Claesson-Welsh L.
      Biochem. J.437:169-183(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON LIGAND SPECIFICITY; FUNCTION; STRUCTURE; PHOSPHORYLATION AND SIGNALING
    41. 41.
      "Involvement of Flt-1 (VEGF receptor-1) in cancer and preeclampsia."
      Shibuya M.
      Proc. Jpn. Acad., B, Phys. Biol. Sci.87:167-178(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN CANCER AND PREECLAMPSIA
    42. 42.
      "Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor."
      Wiesmann C. , Fuh G. , Christinger H.W. , Eigenbrot C. , Wells J.A. , de Vos A.M.
      Cell91:695-704(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 132-226 IN COMPLEX WITH VEGFA;DOMAIN
    43. 43.
      "Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states."
      Starovasnik M.A. , Christinger H.W. , Wiesmann C. , Champe M.A. , de Vos A.M. , Skelton N.J.
      J. Mol. Biol.293:531-544(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 129-229;X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 129-229 IN COMPLEX WITH VEGFA;SUBUNIT;INTERACTION WITH VEGFA
    44. 44.
      "The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1."
      Christinger H.W. , Fuh G. , de Vos A.M. , Wiesmann C.
      J. Biol. Chem.279:10382-10388(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 130-229 IN COMPLEX WITH PGF
    45. 45.
      "Structural insights into the binding of vascular endothelial growth factor-B by VEGFR-1(D2): recognition and specificity."
      Iyer S. , Darley P.I. , Acharya K.R.
      J. Biol. Chem.285:23779-23789(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.71 ANGSTROMS) OF 129-226 IN COMPLEX WITH VEGFB;INTERACTION WITH VEGFB;SUBUNIT;DOMAIN
    46. 46.
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