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Index > Protein center > QKI(Gene name) > Human
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  • QKI (Gene name),
  • Protein quaking (Protein name ),  QKI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    QKI(HKQ);
    Protein name:
    Protein quaking(Hqk;HqkI);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
    Function:
    RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
    Subcellular Location:
    Nucleus Cytoplasm
    Protein Attributes:
    Sequence length:
    341
    Sequence:
    50:
    MVGEMETKEK | PKPTPDYLMQ | LMNDKKLMSS | LPNFCGIFNH | LERLLDEEIS | 
    100:
    RVRKDMYNDT | LNGSTEKRSA | ELPDAVGPIV | QLQEKLYVPV | KEYPDFNFVG | 
    150:
    RILGPRGLTA | KQLEAETGCK | IMVRGKGSMR | DKKKEEQNRG | KPNWEHLNED | 
    200:
    LHVLITVEDA | QNRAEIKLKR | AVEEVKKLLV | PAAEGEDSLK | KMQLMELAIL | 
    250:
    NGTYRDANIK | SPALAFSLAA | TAQAAPRIIT | GPAPVLPPAA | LRTPTPAGPT | 
    300:
    IMPLIRQIQT | AVMPNGTPHP | TAAIVPPGPE | AGLIYTPYEY | PYTLAPATSI | 
    341:
    LEYPIEPSGV | LGAVATKVRR | HDMRVHPYQR | IVTADRAATG | N
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    SMR:
    MIM:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Hqk
    ELISA Kit for Human Hqk
    ELISA Kit for Human Hqk
    ELISA Kit for Human Hqk
    ELISA Kit for Human Hqk
    ELISA Kit for Human Hqk
    ELISA Kit for Human Hqk
    CLIA Kit for Human Hqk
    CLIA Kit for Human Hqk
    CLIA Kit for Human Hqk
    CLIA Kit for Human Hqk
    CLIA Kit for Human Hqk
    CLIA Kit for Human Hqk
    CLIA Kit for Human Hqk
    Polyclonal Antibody for Human Hqk
    Polyclonal Antibody for Human Hqk
    Polyclonal Antibody for Human Hqk
    Polyclonal Antibody for Human Hqk
    Polyclonal Antibody for Human Hqk
    Polyclonal Antibody for Human Hqk
    Polyclonal Antibody for Human Hqk
    Monoclonal Antibody for Human Hqk
    Monoclonal Antibody for Human Hqk
    Monoclonal Antibody for Human Hqk
    Monoclonal Antibody for Human Hqk
    Monoclonal Antibody for Human Hqk
    Monoclonal Antibody for Human Hqk
    Monoclonal Antibody for Human Hqk
    Protein for Human Hqk
    Protein for Human Hqk
    Protein for Human Hqk
    Protein for Human Hqk
    Protein for Human Hqk
    Protein for Human Hqk
    Protein for Human Hqk

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    References
    1. 1.
      "Expression of Hqk encoding a KH RNA binding protein is altered in human glioma."
      Li Z.Z. , Kondo T. , Murata T. , Ebersole T.A. , Nishi T. , Tada K. , Ushio Y. , Yamamura K. , Abe K.
      Jpn. J. Cancer Res.93:167-177(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 4 AND 5)
      tissue: Brain.
    2. 2.
      "Molecular cloning of human QUAKING gene."
      Xia J.-H. , Xiao J.-F. , He Y.-G. , Yu K.-P. , Pan Q. , Dai H.-P.
      Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-341 (ISOFORM 6)
    3. 3.
      Li H. , Nong W. , Zhou G. , Ke R. , Shen C. , Zhong G. , Liang M. , Tang Z. , Huang B. , Lin L. , Yang S.
      Submitted (2005-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-341 (ISOFORM 3)
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
      tissue: Skin.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-341 (ISOFORM 1)
      tissue: Embryo.
    7. 7.
      "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1."
      Cote J. , Boisvert F.-M. , Boulanger M.-C. , Bedford M.T. , Richard S.
      Mol. Biol. Cell14:274-287(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION
    8. 8.
      "Human QKI, a new candidate gene for schizophrenia involved in myelination."
      Aeberg K. , Saetre P. , Lindholm E. , Ekholm B. , Pettersson U. , Adolfsson R. , Jazin E.
      Am. J. Med. Genet. B Neuropsychiatr. Genet.141:84-90(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 9.
      "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia."
      Aberg K. , Saetre P. , Jareborg N. , Jazin E.
      Proc. Natl. Acad. Sci. U.S.A.103:7482-7487(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS REGULATOR OF OLIGODENDROCYTE DIFFERENTIATION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "A Y2H-seq approach defines the human protein methyltransferase interactome."
      Weimann M. , Grossmann A. , Woodsmith J. , Ozkan Z. , Birth P. , Meierhofer D. , Benlasfer N. , Valovka T. , Timmermann B. , Wanker E.E. , Sauer S. , Stelzl U.
      Nat. Methods10:339-342(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT ARG-242 BY CARM1
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-336
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