Protein name:
Protein quaking (Hqk;HqkI) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
Function:
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B. Regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
Subcellular Location:
Nucleus
Cytoplasm
Protein Attributes:
50:
MVGEMETKEK | PKPTPDYLMQ | LMNDKKLMSS | LPNFCGIFNH | LERLLDEEIS |
100:
RVRKDMYNDT | LNGSTEKRSA | ELPDAVGPIV | QLQEKLYVPV | KEYPDFNFVG |
150:
RILGPRGLTA | KQLEAETGCK | IMVRGKGSMR | DKKKEEQNRG | KPNWEHLNED |
200:
LHVLITVEDA | QNRAEIKLKR | AVEEVKKLLV | PAAEGEDSLK | KMQLMELAIL |
250:
NGTYRDANIK | SPALAFSLAA | TAQAAPRIIT | GPAPVLPPAA | LRTPTPAGPT |
300:
IMPLIRQIQT | AVMPNGTPHP | TAAIVPPGPE | AGLIYTPYEY | PYTLAPATSI |
341:
LEYPIEPSGV | LGAVATKVRR | HDMRVHPYQR | IVTADRAATG | N
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Rat
Mouse
Human
Bovine
Pig
Chicken
Polyclonal Antibody for Human Hqk
Polyclonal Antibody for Human Hqk
Polyclonal Antibody for Human Hqk
Polyclonal Antibody for Human Hqk
Polyclonal Antibody for Human Hqk
Polyclonal Antibody for Human Hqk
Polyclonal Antibody for Human Hqk
Monoclonal Antibody for Human Hqk
Monoclonal Antibody for Human Hqk
Monoclonal Antibody for Human Hqk
Monoclonal Antibody for Human Hqk
Monoclonal Antibody for Human Hqk
Monoclonal Antibody for Human Hqk
Monoclonal Antibody for Human Hqk
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 4 AND 5)
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-341 (ISOFORM 6)
3.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-341 (ISOFORM 3)
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"The DNA sequence and analysis of human chromosome 6."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Placenta .
tissue :
Skin .
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-341 (ISOFORM 1)
tissue :
Embryo .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : METHYLATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS REGULATOR OF OLIGODENDROCYTE DIFFERENTIATION
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : METHYLATION AT ARG-242 BY CARM1
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] GLN-336