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Index > Protein center > Qki(Gene name) > Mouse
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  • Qki (Gene name),
  • Protein quaking (Protein name ),  QKI_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Qki(Qk;Qk1;Qka1);
    Protein name:
    Protein quaking(MqkI;qkI);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
    Function:
    RNA-binding protein that plays a central role in myelinization. Also required for visceral endoderm function and blood vessel development. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Isoform 1 is involved in regulation of mRNA splicing of MAG pre-mRNA by acting as a negative regulator of MAG exon 12 alternative splicing. Isoform 3 can induce apoptosis, while heterodimerization with other isoforms results in nuclear translocation of isoform 3 and suppression of apoptosis. Isoform 4 acts as a translational repressor for GLI1. May also play a role in smooth muscle development.
    Subcellular Location:
    Isoform 4 Cytoplasm Nucleus Isoform 4 localizes both in the cytoplasm and nucleus.
    Protein Attributes:
    Sequence length:
    341
    Sequence:
    50:
    MVGEMETKEK | PKPTPDYLMQ | LMNDKKLMSS | LPNFCGIFNH | LERLLDEEIS | 
    100:
    RVRKDMYNDT | LNGSTEKRSA | ELPDAVGPIV | QLQEKLYVPV | KEYPDFNFVG | 
    150:
    RILGPRGLTA | KQLEAETGCK | IMVRGKGSMR | DKKKEEQNRG | KPNWEHLNED | 
    200:
    LHVLITVEDA | QNRAEIKLKR | AVEEVKKLLV | PAAEGEDSLK | KMQLMELAIL | 
    250:
    NGTYRDANIK | SPALAFSLAA | TAQAAPRIIT | GPAPVLPPAA | LRTPTPAGPT | 
    300:
    IMPLIRQIQT | AVMPNGTPHP | TAAIVPPGPE | AGLIYTPYEY | PYTLAPATSI | 
    341:
    LEYPIEPSGV | LGAVATKVRR | HDMRVHPYQR | IVTADRAATG | N
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MqkI
    ELISA Kit for Mouse MqkI
    ELISA Kit for Mouse MqkI
    ELISA Kit for Mouse MqkI
    ELISA Kit for Mouse MqkI
    ELISA Kit for Mouse MqkI
    ELISA Kit for Mouse MqkI
    CLIA Kit for Mouse MqkI
    CLIA Kit for Mouse MqkI
    CLIA Kit for Mouse MqkI
    CLIA Kit for Mouse MqkI
    CLIA Kit for Mouse MqkI
    CLIA Kit for Mouse MqkI
    CLIA Kit for Mouse MqkI
    Polyclonal Antibody for Mouse MqkI
    Polyclonal Antibody for Mouse MqkI
    Polyclonal Antibody for Mouse MqkI
    Polyclonal Antibody for Mouse MqkI
    Polyclonal Antibody for Mouse MqkI
    Polyclonal Antibody for Mouse MqkI
    Polyclonal Antibody for Mouse MqkI
    Monoclonal Antibody for Mouse MqkI
    Monoclonal Antibody for Mouse MqkI
    Monoclonal Antibody for Mouse MqkI
    Monoclonal Antibody for Mouse MqkI
    Monoclonal Antibody for Mouse MqkI
    Monoclonal Antibody for Mouse MqkI
    Monoclonal Antibody for Mouse MqkI
    Protein for Mouse MqkI
    Protein for Mouse MqkI
    Protein for Mouse MqkI
    Protein for Mouse MqkI
    Protein for Mouse MqkI
    Protein for Mouse MqkI
    Protein for Mouse MqkI

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins."
      Ebersole T.A. , Chen Q. , Justice M.J. , Artzt K.
      Nat. Genet.12:260-265(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);INVOLVEMENT IN QKV;TISSUE SPECIFICITY;MUTAGENESIS OF GLU-48
    2. 2.
      "Genomic organization and expression analysis of the mouse qkI locus."
      Kondo T. , Furuta T. , Mitsunaga K. , Ebersole T.A. , Shichiri M. , Wu J. , Artzt K. , Yamamura K. , Abe K.
      Mamm. Genome10:662-669(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3; 4 AND 7);ALTERNATIVE SPLICING (ISOFORM 1)
      strain: 129/J.
    3. 3.
      "Genomic sequence analysis in the mouse T-complex region."
      Brathwaite M.E. , Waeltz P. , Qian Y. , Dudekula D. , Schlessinger D. , Nagaraja R.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];ALTERNATIVE SPLICING
      strain: C57BL/6J.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-341 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Head.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
      tissue: Embryo.
    6. 6.
      "Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene."
      Cox R.D. , Hugill A. , Shedlovsky A. , Noveroske J.K. , Best S. , Justice M.J. , Lehrach H. , Dove W.F.
      Genomics57:333-341(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 49-341;ALTERNATIVE SPLICING (ISOFORMS 1; 3; 4 AND 8);MUTAGENESIS OF VAL-157
    7. 7.
      "Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice."
      Hardy R.J. , Loushin C.L. , Friedrich V.L. Jr. , Chen Q. , Ebersole T.A. , Lazzarini R.A. , Artzt K.
      J. Neurosci.16:7941-7949(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain."
      Chen T. , Damaj B.B. , Herrera C. , Lasko P. , Richard S.
      Mol. Cell. Biol.17:5707-5718(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;INTERACTION WITH BICC1
    9. 9.
      "QKI expression is regulated during neuron-glial cell fate decisions."
      Hardy R.J.
      J. Neurosci. Res.54:46-57(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    10. 10.
      "Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization."
      Chen T. , Richard S.
      Mol. Cell. Biol.18:4863-4871(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;MUTAGENESIS OF GLU-48
    11. 11.
      "The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm."
      Wu J. , Zhou L. , Tonissen K. , Tee R. , Artzt K.
      J. Biol. Chem.274:29202-29210(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF GLU-48; ARG-324; TYR-328 AND ARG-330
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RNA-BINDING
    13. 13.
      "Destabilization and mislocalization of myelin basic protein mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins."
      Li Z. , Zhang Y. , Li D. , Feng Y.
      J. Neurosci.20:4944-4953(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Nuclear translocation controlled by alternatively spliced isoforms inactivates the QUAKING apoptotic inducer."
      Pilotte J. , Larocque D. , Richard S.
      Genes Dev.15:845-858(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;SUBUNIT
    15. 15.
      "Nuclear retention of MBP mRNAs in the quaking viable mice."
      Larocque D. , Pilotte J. , Chen T. , Cloutier F. , Massie B. , Pedraza L. , Couture R. , Lasko P. , Almazan G. , Richard S.
      Neuron36:815-829(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RNA-BINDING;MUTAGENESIS OF VAL-157
    16. 16.
      "Function of quaking in myelination: regulation of alternative splicing."
      Wu J.I. , Reed R.B. , Grabowski P.J. , Artzt K.
      Proc. Natl. Acad. Sci. U.S.A.99:4233-4238(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF VAL-157
    18. 18.
      "Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism."
      Zhang Y. , Lu Z. , Ku L. , Chen Y. , Wang H. , Feng Y.
      EMBO J.22:1801-1810(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;MUTAGENESIS OF 276-PRO--PRO-279; TYR-285; TYR-288; TYR-290; TYR-292 AND TYR-303
    19. 19.
      "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1."
      Cote J. , Boisvert F.-M. , Boulanger M.-C. , Bedford M.T. , Richard S.
      Mol. Biol. Cell14:274-287(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION
    20. 20.
      "The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system."
      Lu Z. , Zhang Y. , Ku L. , Wang H. , Ahmadian A. , Feng Y.
      Nucleic Acids Res.31:4616-4624(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN QKV
    21. 21.
      "The neurological mutant quaking(viable) is Parkin deficient."
      Lorenzetti D. , Antalffy B. , Vogel H. , Noveroske J. , Armstrong D. , Justice M.
      Mamm. Genome15:210-217(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN QKV
    22. 22.
      "STAR proteins quaking-6 and GLD-1 regulate translation of the homologues GLI1 and tra-1 through a conserved RNA 3'UTR-based mechanism."
      Lakiza O. , Frater L. , Yoo Y. , Villavicencio E. , Walterhouse D. , Goodwin E.B. , Iannaccone P.
      Dev. Biol.287:98-110(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    23. 23.
      "Defective smooth muscle development in qkI-deficient mice."
      Li Z. , Takakura N. , Oike Y. , Imanaka T. , Araki K. , Suda T. , Kaname T. , Kondo T. , Abe K. , Yamamura K.
      Dev. Growth Differ.45:449-462(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    24. 24.
      "Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation."
      Lu Z. , Ku L. , Chen Y. , Feng Y.
      J. Biol. Chem.280:389-395(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    25. 25.
      "Protection of p27(Kip1) mRNA by quaking RNA binding proteins promotes oligodendrocyte differentiation."
      Larocque D. , Galarneau A. , Liu H.-N. , Scott M. , Almazan G. , Richard S.
      Nat. Neurosci.8:27-33(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RNA-BINDING
    26. 26.
      "Target RNA motif and target mRNAs of the Quaking STAR protein."
      Galarneau A. , Richard S.
      Nat. Struct. Mol. Biol.12:691-698(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA-BINDING
    27. 27.
      "Visceral endoderm function is regulated by quaking and required for vascular development."
      Bohnsack B.L. , Lai L. , Northrop J.L. , Justice M.J. , Hirschi K.K.
      Genesis44:93-104(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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