Protein name:
Protein quaking (RqkI) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
Function:
RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.
Subcellular Location:
Nucleus
Cytoplasm
Protein Attributes:
50:
MVGEMETKEN | PNPTPDYLMQ | LMNDKKLMSS | LPNFCGIFNH | LERLLDEEIS |
100:
RVRKDMYNDT | LNGSTEKRSA | ELPDAVGPIV | QLQEKLYVPV | KEYPDFNFVG |
150:
RILGPRGLTA | KQLEAETGCK | IMVRGKGSMR | DKKKEEQNRG | KPNWEHLNED |
200:
LHVLITVEDA | QNRAEIKLKR | AVEEVKKLLV | PAAEGEDSLK | KMQLMELAIL |
250:
NGTYRDANIK | SPALAFSLAA | TAQAAPRIIT | GPAPVLPPAA | LRTPTPAGPT |
300:
IMPLIRQIQT | AVMPNGTPHP | TAAIVPPGPE | AGLIYTPYEY | PYTLAPATSI |
341:
LEYPIEPSGV | LGAVATKVRR | HDMRVHPYQR | IVTADRAATG | N
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Rat
Mouse
Human
Bovine
Pig
Chicken
Polyclonal Antibody for Rat RqkI
Polyclonal Antibody for Rat RqkI
Polyclonal Antibody for Rat RqkI
Polyclonal Antibody for Rat RqkI
Polyclonal Antibody for Rat RqkI
Polyclonal Antibody for Rat RqkI
Polyclonal Antibody for Rat RqkI
Monoclonal Antibody for Rat RqkI
Monoclonal Antibody for Rat RqkI
Monoclonal Antibody for Rat RqkI
Monoclonal Antibody for Rat RqkI
Monoclonal Antibody for Rat RqkI
Monoclonal Antibody for Rat RqkI
Monoclonal Antibody for Rat RqkI
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 98-302
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY