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Index > Protein center > RECQL(Gene name) > Human
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  • RECQL (Gene name),
  • ATP-dependent DNA helicase Q1 (Protein name ),  RECQ1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RECQL(RECQ1;RECQL1);
    Protein name:
    ATP-dependent DNA helicase Q1;
    Alternative:
    DNA-dependent ATPase Q1;DNA helicase, RecQ-like type 1(RecQ1);RecQ protein-like 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with EXO1 and MLH1.
    Function:
    DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    649
    Sequence:
    50:
    MASVSALTEE | LDSITSELHA | VEIQIQELTE | RQQELIQKKK | VLTKKIKQCL | 
    100:
    EDSDAGASNE | YDSSPAAWNK | EDFPWSGKVK | DILQNVFKLE | KFRPLQLETI | 
    150:
    NVTMAGKEVF | LVMPTGGGKS | LCYQLPALCS | DGFTLVICPL | ISLMEDQLMV | 
    200:
    LKQLGISATM | LNASSSKEHV | KWVHAEMVNK | NSELKLIYVT | PEKIAKSKMF | 
    250:
    MSRLEKAYEA | RRFTRIAVDE | VHCCSQWGHD | FRPDYKALGI | LKRQFPNASL | 
    300:
    IGLTATATNH | VLTDAQKILC | IEKCFTFTAS | FNRPNLYYEV | RQKPSNTEDF | 
    350:
    IEDIVKLING | RYKGQSGIIY | CFSQKDSEQV | TVSLQNLGIH | AGAYHANLEP | 
    400:
    EDKTTVHRKW | SANEIQVVVA | TVAFGMGIDK | PDVRFVIHHS | MSKSMENYYQ | 
    450:
    ESGRAGRDDM | KADCILYYGF | GDIFRISSMV | VMENVGQQKL | YEMVSYCQNI | 
    500:
    SKCRRVLMAQ | HFDEVWNSEA | CNKMCDNCCK | DSAFERKNIT | EYCRDLIKIL | 
    550:
    KQAEELNEKL | TPLKLIDSWM | GKGAAKLRVA | GVVAPTLPRE | DLEKIIAHFL | 
    600:
    IQQYLKEDYS | FTAYATISYL | KIGPKANLLN | NEAHAITMQV | TKSTQNSFRA | 
    649:
    ESSQTCHSEQ | GDKKMEEKNS | GNFQKKAANM | LQQSGSKNTG | AKKRKIDDA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human ATP-dependent DNA helicase Q1
    ELISA Kit for Human ATP-dependent DNA helicase Q1
    ELISA Kit for Human ATP-dependent DNA helicase Q1
    CLIA Kit for Human ATP-dependent DNA helicase Q1
    CLIA Kit for Human ATP-dependent DNA helicase Q1
    CLIA Kit for Human ATP-dependent DNA helicase Q1
    Polyclonal Antibody for Human ATP-dependent DNA helicase Q1
    Polyclonal Antibody for Human ATP-dependent DNA helicase Q1
    Polyclonal Antibody for Human ATP-dependent DNA helicase Q1
    Monoclonal Antibody for Human ATP-dependent DNA helicase Q1
    Monoclonal Antibody for Human ATP-dependent DNA helicase Q1
    Monoclonal Antibody for Human ATP-dependent DNA helicase Q1
    Protein for Human ATP-dependent DNA helicase Q1
    Protein for Human ATP-dependent DNA helicase Q1
    Protein for Human ATP-dependent DNA helicase Q1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ."
      Puranam K.L. , Blackshear P.J.
      J. Biol. Chem.269:29838-29845(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 34-38; 186-193; 293-304; 396-404; 431-439 AND 594-599;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;VARIANT THR-487
      tissue: Cervix carcinoma.
    2. 2.
      "Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12."
      Seki M. , Miyazawa H. , Tada S. , Yanagisawa J. , Yamaoka T. , Hoshino S. , Ozawa K. , Eki T. , Nogami M. , Okumura K. , Taguchi H. , Hanaoka F. , Enomoto T.
      Nucleic Acids Res.22:4566-4573(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    8. 8.
      "Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes."
      Seki M. , Yanagisawa J. , Kohda T. , Sonoyama T. , Ui M. , Enomoto T.
      J. Biochem.115:523-531(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination."
      Doherty K.M. , Sharma S. , Uzdilla L.A. , Wilson T.M. , Cui S. , Vindigni A. , Brosh R.M. Jr.
      J. Biol. Chem.280:28085-28094(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EXO1 AND MLH1;MUTAGENESIS OF LYS-119
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-514 AND LYS-522;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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