RECQL4 ELISA Kit for Human(Homo sapiens) | EIAab.comRECQL4 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > RECQL4(Gene name) > Human

RECQL4 (Gene name),

ATP-dependent DNA helicase Q4 (Protein name ), RECQ4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RECQL4(RECQ4);

Protein name:

ATP-dependent DNA helicase Q4;

Alternative:

RTS;DNA helicase, RecQ-like type 4(RecQ4);RecQ protein-like 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with UBR1 and UBR2. Interacts with MCM10; this interaction regulates RECQL4 unwinding activity.

Function:

DNA-dependent ATPase. May modulate chromosome segregation.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

1208

Sequence:

50:

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1050:

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1150:

1200:

1208:

EELLQVAR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00270

KEGG:

hsa:9401

STRING:

9606.ENSP00000410312

UniGene:

Hs.31442

String:

O94761

SMR:

O94761

MIM:

218600

Uniprot:

O94761

FOR

ELISA Kit for Human ATP-dependent DNA helicase Q4

CLIA Kit for Human ATP-dependent DNA helicase Q4

Polyclonal Antibody for Human ATP-dependent DNA helicase Q4

Monoclonal Antibody for Human ATP-dependent DNA helicase Q4

Protein for Human ATP-dependent DNA helicase Q4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes."
Kitao S. , Ohsugi I. , Ichikawa K. , Goto M. , Furuichi Y. , Shimamoto A.
Genomics54:443-452(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Testis.
2.

"Rothmund-Thomson syndrome responsible gene, RECQL4: genomic structure and products."
Kitao S. , Lindor N.M. , Shiratori M. , Furuichi Y. , Shimamoto A.
Genomics61:268-276(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];SUBCELLULAR LOCATION;INVOLVEMENT IN ROTHMUND-THOMSON SYNDROME
3.

NIEHS SNPs program
Submitted (2005-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-54; GLY-71; SER-92; SER-189; ASP-267; THR-273; LYS-301; CYS-522; HIS-522; LEU-591; SER-793; MET-799; THR-964; LYS-976; TRP-1004; GLN-1005; GLN-1021; THR-1045; SER-1105; ASP-1105; HIS-1106; ARG-1113 AND PHE-1148
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 468-1208
tissue: Lymph.
tissue: Placenta.
5.

"Differential regulation of human RecQ family helicases in cell transformation and cell cycle."
Kawabe T. , Tsuyama N. , Kitao S. , Nishikawa K. , Shimamoto A. , Shiratori M. , Matsumoto T. , Anno K. , Sato T. , Mitsui Y. , Seki M. , Enomoto T. , Goto M. , Ellis N.A. , Ide T. , Furuichi Y. , Sugimoto M.
Oncogene19:4764-4772(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
6.

"Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases."
Siitonen H.A. , Kopra O. , Kaeaeriaeinen H. , Haravuori H. , Winter R.M. , Saeaemaenen A.-M. , Peltonen L. , Kestilae M.
Hum. Mol. Genet.12:2837-2844(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN RAPADILINOS
7.

"RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway."
Yin J. , Kwon Y.T. , Varshavsky A. , Wang W.
Hum. Mol. Genet.13:2421-2430(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBR1 AND UBR2;SUBCELLULAR LOCATION;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
8.

"MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication."
Xu X. , Rochette P.J. , Feyissa E.A. , Su T.V. , Liu Y.
EMBO J.28:3005-3014(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MCM10
9.

"Identification of two novel RECQL4exonic SNPs and genomic characterization of the IVS12 minisatellite."
Roversi G. , Beghini A. , Zambruno G. , Paradisi M. , Larizza L.
J. Hum. Genet.48:107-109(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-267 AND GLN-1005
10.

"Mutation analysis of the RECQL4 gene in sporadic osteosarcomas."
Nishijo K. , Nakayama T. , Aoyama T. , Okamoto T. , Ishibe T. , Yasura K. , Shima Y. , Shibata K.R. , Tsuboyama T. , Nakamura T. , Toguchida J.
Int. J. Cancer111:367-372(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLN-355; SER-441 AND 857-CYS--THR-858 DEL
11.

"Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene."
Van Maldergem L. , Siitonen H.A. , Jalkh N. , Chouery E. , De Roy M. , Delague V. , Muenke M. , Jabs E.W. , Cai J. , Wang L.L. , Plon S.E. , Fourneau C. , Kestilae M. , Gillerot Y. , Megarbane A. , Verloes A.
J. Med. Genet.43:148-152(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BGS TRP-1021;VARIANT THR-523

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