Protein name:
Ribonucleoside-diphosphate reductase large subunit ;
Alternative:
Ribonucleotide reductase large subunit ;Ribonucleoside-diphosphate reductase subunit M1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer of a large and a small subunit. Heterodimer with small subunit RRM2 or RRM2B. The heterodimer with RRM2 has higher catalytic activity than the heterodimer with RRM2B.
Function:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MHVIKRDGRQ | ERVMFDKITS | RIQKLCYGLN | MDFVDPAQIT | MKVIQGLYSG |
100:
VTTVELDTLA | AETAATLTTK | HPDYAILAAR | IAVSNLHKET | KKVFSDVMED |
150:
LYNYINPHNG | KHSPMVAKST | LDIVLANKDR | LNSAIIYDRD | FSYNYFGFKT |
200:
LERSYLLKIN | GKVAERPQHM | LMRVSVGIHK | EDIDAAIETY | NLLSERWFTH |
250:
ASPTLFNAGT | NRPQLSSCFL | LSMKDDSIEG | IYDTLKQCAL | ISKSAGGIGV |
300:
AVSCIRATGS | YIAGTNGNSN | GLVPMLRVYN | NTARYVDQGG | NKRPGAFAIY |
350:
LEPWHLDIFE | FLDLKKNTGK | EEQRARDLFF | ALWIPDLFMK | RVETNQDWSL |
400:
MCPNECPGLD | EVWGEEFEKL | YASYEKQGRV | RKVVKAQQLW | YAIIESQTET |
450:
GTPYMLYKDS | CNRKSNQQNL | GTIKCSNLCT | EIVEYTSKDE | VAVCNLASLA |
500:
LNMYVTSEHT | YDFKKLAEVT | KVVVRNLNKI | IDINYYPVPE | ACLSNKRHRP |
550:
IGIGVQGLAD | AFILMRYPFE | SAEAQLLNKQ | IFETIYYGAL | EASCDLAKEQ |
600:
GPYETYEGSP | VSKGILQYDM | WNVTPTDLWD | WKVLKEKIAK | YGIRNSLLIA |
650:
PMPTASTAQI | LGNNESIEPY | TSNIYTRRVL | SGEFQIVNPH | LLKDLTERGL |
700:
WHEEMKNQII | ACNGSIQSIP | EIPDDLKQLY | KTVWEISQKT | VLKMAAERGA |
750:
FIDQSQSLNI | HIAEPNYGKL | TSMHFYGWKQ | GLKTGMYYLR | TRPAANPIQF |
792:
TLNKEKLKDK | EKVSKEEEEK | ERNTAAMVCS | LENRDECLMC | GS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Ribonucleoside-diphosphate reductase large subunit
ELISA Kit for Human Ribonucleoside-diphosphate reductase large subunit
CLIA Kit for Human Ribonucleoside-diphosphate reductase large subunit
CLIA Kit for Human Ribonucleoside-diphosphate reductase large subunit
Polyclonal Antibody for Human Ribonucleoside-diphosphate reductase large subunit
Polyclonal Antibody for Human Ribonucleoside-diphosphate reductase large subunit
Monoclonal Antibody for Human Ribonucleoside-diphosphate reductase large subunit
Monoclonal Antibody for Human Ribonucleoside-diphosphate reductase large subunit
Protein for Human Ribonucleoside-diphosphate reductase large subunit
Protein for Human Ribonucleoside-diphosphate reductase large subunit
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Bone marrow .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Mammary carcinoma .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lymph .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-6
tissue :
Placenta .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RRM2B
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY;SUBUNIT;ENZYME REGULATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-17 AND LYS-376;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;MUTAGENESIS OF ASP-57;INTERACTION WITH AHCYL1
12.
"Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization."
Fairman J.W.
,
Wijerathna S.R.
,
Ahmad M.F.
,
Xu H.
,
Nakano R.
,
Jha S.
,
Prendergast J.
,
Welin R.M.
,
Flodin S.
,
Roos A.
,
Nordlund P.
,
Li Z.
,
Walz T.
,
Dealwis C.G.
Nat. Struct. Mol. Biol.18:316-322(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 75-742 IN COMPLEX WITH ALLOSTERIC EFFECTOR ATP AND MAGNESIUM IONS