Gene name:
RNLS (C10orf59) ;
Protein name:
Renalase ;
Alternative:
Monoamine oxidase-C (MAO-C) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.
Subcellular Location:
Secreted
Protein Attributes:
50:
MAQVLIVGAG | MTGSLCAALL | RRQTSGPLYL | AVWDKAEDSG | GRMTTACSPH |
100:
NPQCTADLGA | QYITCTPHYA | KKHQRFYDEL | LAYGVLRPLS | SPIEGMVMKE |
150:
GDCNFVAPQG | ISSIIKHYLK | ESGAEVYFRH | RVTQINLRDD | KWEVSKQTGS |
200:
PEQFDLIVLT | MPVPEILQLQ | GDITTLISEC | QRQQLEAVSY | SSRYALGLFY |
250:
EAGTKIDVPW | AGQYITSNPC | IRFVSIDNKK | RNIESSEIGP | SLVIHTTVPF |
300:
GVTYLEHSIE | DVQELVFQQL | ENILPGLPQP | IATKCQKWRH | SQVTNAAANC |
342:
PGQMTLHHKP | FLACGGDGFT | QSNFDGCITS | ALCVLEALKN | YI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Renalase
ELISA Kit for Human Renalase
ELISA Kit for Human Renalase
CLIA Kit for Human Renalase
CLIA Kit for Human Renalase
CLIA Kit for Human Renalase
Polyclonal Antibody for Human Renalase
Polyclonal Antibody for Human Renalase
Polyclonal Antibody for Human Renalase
Monoclonal Antibody for Human Renalase
Monoclonal Antibody for Human Renalase
Monoclonal Antibody for Human Renalase
Protein for Human Renalase
Protein for Human Renalase
Protein for Human Renalase
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Pitor S, Joanna P, Urszula D, et al.
[2].
N M Serwin, M Wiśniewska, A Jesionowska, et al.
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Nat. Genet.36:40-45(2004)
[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Placenta .
2.
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-37
tissue :
Kidney .
4.
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J. Clin. Invest.115:1275-1280(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY (ISOFORM 1)
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS);COFACTOR;FAD-BINDING SITES