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Index > Protein center > RNLS(Gene name) > Human
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  • RNLS (Gene name),
  • Renalase (Protein name ),  RNLS_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    RNLS(C10orf59);
    Protein name:
    Renalase;
    Alternative:
    Monoamine oxidase-C(MAO-C);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    342
    Sequence:
    50:
    MAQVLIVGAG | MTGSLCAALL | RRQTSGPLYL | AVWDKAEDSG | GRMTTACSPH | 
    100:
    NPQCTADLGA | QYITCTPHYA | KKHQRFYDEL | LAYGVLRPLS | SPIEGMVMKE | 
    150:
    GDCNFVAPQG | ISSIIKHYLK | ESGAEVYFRH | RVTQINLRDD | KWEVSKQTGS | 
    200:
    PEQFDLIVLT | MPVPEILQLQ | GDITTLISEC | QRQQLEAVSY | SSRYALGLFY | 
    250:
    EAGTKIDVPW | AGQYITSNPC | IRFVSIDNKK | RNIESSEIGP | SLVIHTTVPF | 
    300:
    GVTYLEHSIE | DVQELVFQQL | ENILPGLPQP | IATKCQKWRH | SQVTNAAANC | 
    342:
    PGQMTLHHKP | FLACGGDGFT | QSNFDGCITS | ALCVLEALKN | YI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    MIM:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Renalase
    Cat.:
    E1103h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Renalase
    Cat.:
    E1103r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Renalase
    Cat.:
    E1103m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Renalase
    Cat.:
    U1103m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Renalase
    Cat.:
    U1103r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Renalase
    Cat.:
    U1103h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Renalase
    Cat.:
    P1103Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Renalase
    Cat.:
    P1103Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Renalase
    Cat.:
    P1103Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Renalase
    Monoclonal Antibody for Human Renalase
    Monoclonal Antibody for Human Renalase
    Protein for Human Renalase
    Protein for Human Renalase
    Protein for Human Renalase
    Cat.:
    R1103h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    2. 2.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-37
      tissue: Kidney.
    4. 4.
      "Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure."
      Xu J. , Li G. , Wang P. , Velazquez H. , Yao X. , Li Y. , Wu Y. , Peixoto A. , Crowley S. , Desir G.V.
      J. Clin. Invest.115:1275-1280(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    5. 5.
      "Renalase, a catecholamine-metabolising enzyme?"
      Boomsma F. , Tipton K.F.
      J. Neural Transm.114:775-776(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY (ISOFORM 1)
    7. 7.
      "FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulation."
      Milani M. , Ciriello F. , Baroni S. , Pandini V. , Canevari G. , Bolognesi M. , Aliverti A.
      J. Mol. Biol.411:463-473(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS);COFACTOR;FAD-BINDING SITES
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