KITLG ELISA Kit for Human(Homo sapiens) | EIAab.comKITLG ELISA Kit for Human(Homo sapiens)

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Index > Protein center > KITLG(Gene name) > Human

KITLG (Gene name),

Kit ligand (Protein name ), SCF_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

KITLG(MGF;SCF);

Protein name:

Kit ligand;

Alternative:

Stem cell factor(SCF);Mast cell growth factor(MGF);c-Kit ligand;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.

Function:

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Subcellular Location:

Soluble KIT ligand Secreted

Protein Attributes:

Sequence length:

273

Sequence:

50:

100:

150:

200:

250:

273:

IQINEEDNEI | SMLQEKEREF | QEV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.1048

STRING:

9606.ENSP00000228280

Pfam:

PF02404

KEGG:

hsa:4254

SMR:

P21583

String:

P21583

MIM:

145250

Uniprot:

P21583

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ELISA Kit for Human Kit ligand

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E0120r

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96T

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ELISA Kit for Human Kit ligand

Cat.:

E0120h

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96T

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ELISA Kit for Human Kit ligand

Cat.:

E0120m

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96T

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ELISA Kit for Human Kit ligand

Cat.:

E0120b

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96T

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ELISA Kit for Human Kit ligand

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E0120c

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96T

ELISA Kit for Human Kit ligand

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E0120d

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96T

ELISA Kit for Human Kit ligand

Cat.:

E0120p

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96T

CLIA Kit for Human Kit ligand

Cat.:

U0120p

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96T

CLIA Kit for Human Kit ligand

Cat.:

U0120c

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96T

CLIA Kit for Human Kit ligand

Cat.:

U0120d

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96T

CLIA Kit for Human Kit ligand

Cat.:

U0120r

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96T

CLIA Kit for Human Kit ligand

Cat.:

U0120h

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96T

CLIA Kit for Human Kit ligand

Cat.:

U0120b

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Kit ligand

Cat.:

U0120m

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96T

Polyclonal Antibody for Human Kit ligand

Cat.:

P0120Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Kit ligand

Cat.:

P0120Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Kit ligand

Cat.:

P0120Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Kit ligand

Monoclonal Antibody for Human Kit ligand

Protein for Human Kit ligand

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Primary structure and functional expression of rat and human stem cell factor DNAs."
Martin F.H. , Suggs S.V. , Langley K.E. , Lu H.S. , Ting J. , Okino K.H. , Morris C.F. , McNiece I.K. , Jacobsen F.W. , Mendiaz E.A. , Birkett N.C. , Smith K.A. , Johnson M.J. , Parker V.P. , Flores J.C. , Patel A.C. , Fisher E.F. , Erjavec H.O. , more...
Cell63:203-211(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24."
Anderson D.M. , Williams D.E. , Tushinski R. , Gimpel S. , Eisenman J. , Cannizzaro L.A. , Aronson M. , Croce C.M. , Huebner K. , Cosman D.
Cell Growth Differ.2:373-378(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

"Parathyroid hormone-regulated production of stem cell factor in human osteoblasts and osteoblast-like cells."
Blair H.C. , Julian B.A. , Cao X. , Jordan S.E. , Dong S.S.
Biochem. Biophys. Res. Commun.255:778-784(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
4.

Han C. , Peng X. , Yuan J. , Qiang B.
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Tongue.
tissue: Trachea.
6.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Amygdala.
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
tissue: Colon.
9.

"Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells."
Lu H.S. , Clogston C.L. , Wypych J. , Parker V.P. , Lee T.D. , Swiderek K. , Baltera R.F. Jr. , Patel A.C. , Chang D.C. , Brankow D.W. , Liu X.-D. , Ogden S.G. , Karkare S.B. , Hu S.S. , Zsebo K.M. , Langley K.E.
Arch. Biochem. Biophys.298:150-158(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-40; 64-79; 87-102; 110-149 AND 154-190 (ISOFORM 1);DISULFIDE BONDS;SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING;GLYCOSYLATION AT ASN-90; ASN-118; ASN-145; SER-167; THR-168 AND THR-180
10.

"Expression of two types of kit ligand mRNAs in human tumor cells."
Toyota M. , Hinoda Y. , Itoh F. , Tsujisaki M. , Imai K. , Yachi A.
Int. J. Hematol.55:301-304(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-248 (ISOFORM 2)
11.

"Stem cell factor/c-kit system in spermatogenesis."
Mauduit C. , Hamamah S. , Benahmed M.
Hum. Reprod. Update5:535-545(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
12.

"Signal transduction via the stem cell factor receptor/c-Kit."
Ronnstrand L.
Cell. Mol. Life Sci.61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
13.

"Normal and oncogenic forms of the receptor tyrosine kinase kit."
Lennartsson J. , Jelacic T. , Linnekin D. , Shivakrupa R.
Stem Cells23:16-43(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
14.

"Genetic determinants of hair, eye and skin pigmentation in Europeans."
Sulem P. , Gudbjartsson D.F. , Stacey S.N. , Helgason A. , Rafnar T. , Magnusson K.P. , Manolescu A. , Karason A. , Palsson A. , Thorleifsson G. , Jakobsdottir M. , Steinberg S. , Palsson S. , Jonasson F. , Sigurgeirsson B. , Thorisdottir K. , Ragnarsson R. , Benediktsdottir K.R. , more...
Nat. Genet.39:1443-1452(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SHEP7
15.

"A molecular basis for classic blond hair color in Europeans."
Guenther C.A. , Tasic B. , Luo L. , Bedell M.A. , Kingsley D.M.
Nat. Genet.46:748-752(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM LINKED TO BLOND HAIR COLOR
16.

"Structure of the active core of human stem cell factor and analysis of binding to its receptor kit."
Jiang X. , Gurel O. , Mendiaz E.A. , Stearns G.W. , Clogston C.L. , Lu H.S. , Osslund T.D. , Syed R.S. , Langley K.E. , Hendrickson W.A.
EMBO J.19:3192-3203(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS);DISULFIDE BONDS
17.

"Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation."
Zhang Z. , Zhang R. , Joachimiak A. , Schlessinger J. , Kong X.P.
Proc. Natl. Acad. Sci. U.S.A.97:7732-7737(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-166;DISULFIDE BONDS
18.

"Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor."
Yuzawa S. , Opatowsky Y. , Zhang Z. , Mandiyan V. , Lax I. , Schlessinger J.
Cell130:323-334(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 26-166 IN COMPLEX WITH KIT;DISULFIDE BONDS
19.

"Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation."
Wang Z.-Q. , Si L. , Tang Q. , Lin D. , Fu Z. , Zhang J. , Cui B. , Zhu Y. , Kong X. , Deng M. , Xia Y. , Xu H. , Le W. , Hu L. , Kong X.
Am. J. Hum. Genet.84:672-677(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FPH SER-36;CHARACTERIZATION OF VARIANT FPH SER-36

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