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Index > Protein center > KITLG(Gene name) > Human
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  • KITLG (Gene name),
  • Kit ligand (Protein name ),  SCF_HUMAN from NCBI database.
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  • Gene name:
    KITLG(MGF;SCF);
    Protein name:
    Kit ligand;
    Alternative:
    Stem cell factor(SCF);Mast cell growth factor(MGF);c-Kit ligand;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.
    Function:
    Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
    Subcellular Location:
    Soluble KIT ligand Secreted
    Protein Attributes:
    Sequence length:
    273
    Sequence:
    50:
    MKKTQTWILT | CIYLQLLLFN | PLVKTEGICR | NRVTNNVKDV | TKLVANLPKD | 
    100:
    YMITLKYVPG | MDVLPSHCWI | SEMVVQLSDS | LTDLLDKFSN | ISEGLSNYSI | 
    150:
    IDKLVNIVDD | LVECVKENSS | KDLKKSFKSP | EPRLFTPEEF | FRIFNRSIDA | 
    200:
    FKDFVVASET | SDCVVSSTLS | PEKDSRVSVT | KPFMLPPVAA | SSLRNDSSSS | 
    250:
    NRKAKNPPGD | SSLHWAAMAL | PALFSLIIGF | AFGALYWKKR | QPSLTRAVEN | 
    273:
    IQINEEDNEI | SMLQEKEREF | QEV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    KEGG:
    SMR:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Kit ligand
    Cat.:
    E0120r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Kit ligand
    Cat.:
    E0120h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Kit ligand
    Cat.:
    E0120m
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    MSDS:
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    96T
    Range:
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    ELISA Kit for Human Kit ligand
    Cat.:
    E0120b
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Kit ligand
    Cat.:
    E0120c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Kit ligand
    Cat.:
    E0120d
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Kit ligand
    Cat.:
    E0120p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kit ligand
    Cat.:
    U0120p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kit ligand
    Cat.:
    U0120c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kit ligand
    Cat.:
    U0120d
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Kit ligand
    Cat.:
    U0120r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kit ligand
    Cat.:
    U0120h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Kit ligand
    Cat.:
    U0120b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Kit ligand
    Cat.:
    U0120m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Kit ligand
    Cat.:
    P0120Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kit ligand
    Cat.:
    P0120Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kit ligand
    Polyclonal Antibody for Human Kit ligand
    Polyclonal Antibody for Human Kit ligand
    Cat.:
    P0120Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Kit ligand
    Polyclonal Antibody for Human Kit ligand
    Monoclonal Antibody for Human Kit ligand
    Monoclonal Antibody for Human Kit ligand
    Monoclonal Antibody for Human Kit ligand
    Monoclonal Antibody for Human Kit ligand
    Monoclonal Antibody for Human Kit ligand
    Monoclonal Antibody for Human Kit ligand
    Monoclonal Antibody for Human Kit ligand
    Protein for Human Kit ligand
    Protein for Human Kit ligand
    Protein for Human Kit ligand
    Protein for Human Kit ligand
    Protein for Human Kit ligand
    Protein for Human Kit ligand
    Protein for Human Kit ligand

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    Precision
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Alternate splicing of mRNAs encoding human mast cell growth factor and localization of the gene to chromosome 12q22-q24."
      Anderson D.M. , Williams D.E. , Tushinski R. , Gimpel S. , Eisenman J. , Cannizzaro L.A. , Aronson M. , Croce C.M. , Huebner K. , Cosman D.
      Cell Growth Differ.2:373-378(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "Parathyroid hormone-regulated production of stem cell factor in human osteoblasts and osteoblast-like cells."
      Blair H.C. , Julian B.A. , Cao X. , Jordan S.E. , Dong S.S.
      Biochem. Biophys. Res. Commun.255:778-784(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      Han C. , Peng X. , Yuan J. , Qiang B.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Tongue.
      tissue: Trachea.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Amygdala.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Colon.
    9. 9.
      "Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells."
      Lu H.S. , Clogston C.L. , Wypych J. , Parker V.P. , Lee T.D. , Swiderek K. , Baltera R.F. Jr. , Patel A.C. , Chang D.C. , Brankow D.W. , Liu X.-D. , Ogden S.G. , Karkare S.B. , Hu S.S. , Zsebo K.M. , Langley K.E.
      Arch. Biochem. Biophys.298:150-158(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-40; 64-79; 87-102; 110-149 AND 154-190 (ISOFORM 1);DISULFIDE BONDS;SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING;GLYCOSYLATION AT ASN-90; ASN-118; ASN-145; SER-167; THR-168 AND THR-180
    10. 10.
      "Expression of two types of kit ligand mRNAs in human tumor cells."
      Toyota M. , Hinoda Y. , Itoh F. , Tsujisaki M. , Imai K. , Yachi A.
      Int. J. Hematol.55:301-304(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 167-248 (ISOFORM 2)
    11. 11.
      "Stem cell factor/c-kit system in spermatogenesis."
      Mauduit C. , Hamamah S. , Benahmed M.
      Hum. Reprod. Update5:535-545(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    12. 12.
      "Signal transduction via the stem cell factor receptor/c-Kit."
      Ronnstrand L.
      Cell. Mol. Life Sci.61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    13. 13.
      "Normal and oncogenic forms of the receptor tyrosine kinase kit."
      Lennartsson J. , Jelacic T. , Linnekin D. , Shivakrupa R.
      Stem Cells23:16-43(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SHEP7
    15. 15.
      "A molecular basis for classic blond hair color in Europeans."
      Guenther C.A. , Tasic B. , Luo L. , Bedell M.A. , Kingsley D.M.
      Nat. Genet.46:748-752(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM LINKED TO BLOND HAIR COLOR
    16. 16.
      "Structure of the active core of human stem cell factor and analysis of binding to its receptor kit."
      Jiang X. , Gurel O. , Mendiaz E.A. , Stearns G.W. , Clogston C.L. , Lu H.S. , Osslund T.D. , Syed R.S. , Langley K.E. , Hendrickson W.A.
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