Gene name:
SCARB1 (CD36L1;CLA1) ;
Protein name:
Scavenger receptor class B member 1 (SRB1) ;
Alternative:
CD36 antigen-like 1 ;CD36 and LIMPII analogous 1 (CLA-1) ;SR-BI ;Collagen type I receptor, thrombospondin receptor-like 1 ;
CD:
CD36 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Plays a critical role in HCV attachment and/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer. The C-terminal region binds to PDZK1.
Function:
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Membrane
caveola
Multi-pass membrane protein
Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Protein Attributes:
50:
MGCSAKARWA | AGALGVAGLL | CAVLGAVMIV | MVPSLIKQQV | LKNVRIDPSS |
100:
LSFNMWKEIP | IPFYLSVYFF | DVMNPSEILK | GEKPQVRERG | PYVYREFRHK |
150:
SNITFNNNDT | VSFLEYRTFQ | FQPSKSHGSE | SDYIVMPNIL | VLGAAVMMEN |
200:
KPMTLKLIMT | LAFTTLGERA | FMNRTVGEIM | WGYKDPLVNL | INKYFPGMFP |
250:
FKDKFGLFAE | LNNSDSGLFT | VFTGVQNISR | IHLVDKWNGL | SKVDFWHSDQ |
300:
CNMINGTSGQ | MWPPFMTPES | SLEFYSPEAC | RSMKLMYKES | GVFEGIPTYR |
350:
FVAPKTLFAN | GSIYPPNEGF | CPCLESGIQN | VSTCRFSAPL | FLSHPHFLNA |
400:
DPVLAEAVTG | LHPNQEAHSL | FLDIHPVTGI | PMNCSVKLQL | SLYMKSVAGI |
450:
GQTGKIEPVV | LPLLWFAESG | AMEGETLHTF | YTQLVLMPKV | MHYAQYVLLA |
500:
LGCVLLLVPV | ICQIRSQVGA | GQRAARADSH | SLACWGKGAS | DRTLWPTAAW |
550:
SPPPAAVLRL | CRSGSGHCWG | LRSTLASFAC | RVATTLPVLE | GLGPSLGGGT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Mouse
Bovine
Polyclonal Antibody for Human SRB1
Polyclonal Antibody for Human SRB1
Polyclonal Antibody for Human SRB1
Polyclonal Antibody for Human SRB1
Polyclonal Antibody for Human SRB1
Monoclonal Antibody for Human SRB1
Monoclonal Antibody for Human SRB1
Monoclonal Antibody for Human SRB1
Monoclonal Antibody for Human SRB1
Monoclonal Antibody for Human SRB1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
MOHD KAMAL NIK HASAN, IHSAN SAFWAN KAMARAZAMAN
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue :
Promyelocyte .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
tissue :
Liver .
tissue :
Prostate .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION
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Nature466:707-713(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN HDLCQ16
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SER-2
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SER-2; ILE-135 AND SER-167
14.
"Genetic variant of the scavenger receptor BI in humans."
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N. Engl. J. Med.364:136-145(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SER-297;INVOLVEMENT IN HDLCQ16