Superoxide dismutase [Cu-Zn] (Protein name
), SODC_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Related Databases
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Citations (3)
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Gene name:
SOD1;
Protein name:
Superoxide dismutase [Cu-Zn];
Alternative:
Superoxide dismutase 1(hSod1);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not.
Function:
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Location:
Cytoplasm
The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
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s
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Precision
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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤9.2%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤11.9%
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Recovery
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Recovery was determined by spiking various levels of SODC into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
100
94-106
Plasma
99
92-107
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Linearity
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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of SODC and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
95-104%
97-103%
92-109%
94-107%
EDTA plasma(n=5)
92-106%
96-101%
91-107%
93-106%
heparin plasma(n=5)
93-103%
94-105%
94-105%
95-103%
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.
Lu X.
,
Hui L.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]
7.
"Direct sequencing and cloning of superoxide dismutase 1 from peripheral blood." Staege M.S.
,
Bergmann S.
,
Heins S.
Submitted (2006-11) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA]
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L.
,
Schick M.
,
Neubert P.
,
Schatten R.
,
Henze S.
,
Korn B.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Cited for: PROTEIN SEQUENCE OF 2-154;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-56 AND 120-154;VARIANTS ALS1 GLN-49; ARG-94; THR-113; THR-114; HIS-126 AND THR-150
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 120-154;VARIANT ALS1 THR-152
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PALMITOYLATION AT CYS-7;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-7
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Cited for: SUCCINYLATION AT LYS-123;DESUCCINYLATION BY SIRT5;MUTAGENESIS OF LYS-123
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Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF VARIANT ALS1 ARG-38
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Cited for: X-RAY CRYSTALLOGRAPHY (1.02 ANGSTROMS) OF MUTANT GLU-51/GLU-52/GLN-134;SUBUNIT;MUTAGENESIS OF 51-PHE-GLY-52 AND GLU-134
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Cited for: STRUCTURE BY NMR OF MUTANT GLU51/GLU-52/GLN-134;SUBUNIT
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Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH COPPER AND ZINC IONS;DISULFIDE BOND;SUBUNIT;CHARACTERIZATION OF VARIANTS ALS1 VAL-5 AND ARG-44
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Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF VARIANTS ALS1 ASN-135 AND ARG-47;FORMATION OF FIBRILLAR AGGREGATES
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Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF VARIANTS ALS1 VAL-5 AND THR-114;CHARACTERIZATION OF VARIANTS ALS1 VAL-5 AND THR-114
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Cited for: STRUCTURE BY NMR OF MUTANT ALA-7/SER-112;SUBUNIT
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Cited for: X-RAY CRYSTALLOGRAPHY (1.07 ANGSTROMS) IN COMPLEXES WITH COPPER AND ZINC IONS;DISULFIDE BOND;SUBUNIT
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Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF MUTANTS ALA-7/ALA-112 AND ALA-7/ALA-58/ALA-112/ALA-147;MUTAGENESIS OF CYS-7; CYS-58; CYS-112 AND CYS-147
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Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MUTANT SER-81/SER-84 IN COMPLEX WITH COPPER IONS;SUBUNIT;MUTAGENESIS OF HIS-81 AND ASP-84;COFACTOR
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Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) IN COMPLEX WITH COPPER AND ZINC IONS;SUBUNIT;FORMATION OF FIBRILLAR AGGREGATES BY ZINC-DEPLETED SOD1
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Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF VARIANT ALS1 ARG-86;CHARACTERIZATION OF VARIANT ALS1 ARG-86
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Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF VARIANT ALS1 ARG-86
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Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 2-154 IN COMPLEX WITH ZINC
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Cited for: VARIANTS ALS1 SER-145; THR-146 AND PHE-LEU-GLN-119 INS
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Cited for: CHARACTERIZATION OF VARIANTS ALS1 VAL-5; ARG-38; ARG-47; GLN-49; ARG-86 AND THR-114
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Cited for: CHARACTERIZATION OF VARIANTS ALS1 ARG-38; ARG-47; ARG-86 AND ALA-94;INTERACTION WITH RNF19A;UBIQUITINATION
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Cited for: VARIANTS ALS1 VAL-9; CYS-21; LEU-23; ARG-49; ARG-55; ALA-88; THR-90; MET-98; LEU-119; GLY-125 AND ARG-148
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Cited for: CHARACTERIZATION OF VARIANTS ALS1 ARG-38; ARG-86 AND ARG-94;MUTAGENESIS OF CYS-7; 51-PHE-GLY-52; CYS-58; HIS-81; ASP-84; CYS-112 AND CYS-147;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: CHARACTERIZATION OF VARIANTS ALS1 ARG-55; ALA-91; ALA-94; ASP-94; MET-98 AND PHE-145
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Cited for: CHARACTERIZATION OF VARIANTS ALS1 ARG-86 AND ALA-94;UBIQUITINATION BY MARCH5;SUBCELLULAR LOCATION