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Index > Protein center > TNFAIP8(Gene name) > Human
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  • TNFAIP8 (Gene name),
  • Tumor necrosis factor alpha-induced protein 8 (Protein name ),  TFIP8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFAIP8;
    Protein name:
    Tumor necrosis factor alpha-induced protein 8(TNF alpha-induced protein 8);
    Alternative:
    MDC-3.13;Head and neck tumor and metastasis-related protein;SCC-S2;NF-kappa-B-inducible DED-containing protein(NDED);TNF-induced protein GG2-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    198
    Sequence:
    50:
    MHSEAEESKE | VATDVFNSKN | LAVQAQKKIL | GKMVSKSIAT | TLIDDTSSEV | 
    100:
    LDELYRVTRE | YTQNKKEAEK | IIKNLIKTVI | KLAILYRNNQ | FNQDELALME | 
    150:
    KFKKKVHQLA | MTVVSFHQVD | YTFDRNVLSR | LLNECREMLH | QIIQRHLTAK | 
    198:
    SHGRVNNVFD | HFSDCEFLAA | LYNPFGNFKP | HLQKLCDGIN | KMLDEENI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    UniGene:
    Pfam:
    MIM:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human TNF alpha-induced protein 8
    ELISA Kit for Human TNF alpha-induced protein 8
    ELISA Kit for Human TNF alpha-induced protein 8
    ELISA Kit for Human TNF alpha-induced protein 8
    CLIA Kit for Human TNF alpha-induced protein 8
    CLIA Kit for Human TNF alpha-induced protein 8
    CLIA Kit for Human TNF alpha-induced protein 8
    CLIA Kit for Human TNF alpha-induced protein 8
    Polyclonal Antibody for Human TNF alpha-induced protein 8
    Polyclonal Antibody for Human TNF alpha-induced protein 8
    Polyclonal Antibody for Human TNF alpha-induced protein 8
    Polyclonal Antibody for Human TNF alpha-induced protein 8
    Monoclonal Antibody for Human TNF alpha-induced protein 8
    Monoclonal Antibody for Human TNF alpha-induced protein 8
    Monoclonal Antibody for Human TNF alpha-induced protein 8
    Monoclonal Antibody for Human TNF alpha-induced protein 8
    Protein for Human TNF alpha-induced protein 8
    Protein for Human TNF alpha-induced protein 8
    Protein for Human TNF alpha-induced protein 8
    Protein for Human TNF alpha-induced protein 8

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    References
    1. 1.
      "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes."
      Horrevoets A.J.G. , Fontijn R.D. , van Zonneveld A.J. , de Vries C.J.M. , ten Cate J.W. , Pannekoek H.
      Blood93:3418-3431(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY
      tissue: Umbilical vein.
    2. 2.
      "Identification of cellular factors involved in the differentiation of dendritic cells."
      Nietfeld W. , Meyerhans A.F.
      Submitted (1998-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
      tissue: Placenta.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
      tissue: Urinary bladder.
    7. 8.
      "Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein."
      Kumar D. , Whiteside T.L. , Kasid U.
      J. Biol. Chem.275:2973-2978(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-198 (ISOFORM 3);IDENTIFICATION;FUNCTION;INDUCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      tissue: Heart.
    8. 9.
      "Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity."
      You Z. , Ouyang H. , Lopatin D. , Polver P.J. , Wang C.-Y.
      J. Biol. Chem.276:26398-26404(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    9. 10.
      "Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells."
      Kumar D. , Gokhale P. , Broustas C. , Chakravarty D. , Ahmad I. , Kasid U.
      Oncogene23:612-616(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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