Gene name:
TEK (TIE2;VMCM;VMCM1) ;
Protein name:
Angiopoietin-1 receptor ;
Alternative:
Tyrosine-protein kinase receptor TEK ;Tunica interna endothelial cell kinase ;p140 TEK ;Tyrosine-protein kinase receptor TIE-2 (hTIE2) ;p140 TEK ;Tyrosine-protein kinase receptor TIE-2 (hTIE2) ;
CD:
CD202b ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with PTPRB.
Function:
This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MDSLASLVLC | GVSLLLSGTV | EGAMDLILIN | SLPLVSDAET | SLTCIASGWR |
100:
PHEPITIGRD | FEALMNQHQD | PLEVTQDVTR | EWAKKVVWKR | EKASKINGAY |
150:
FCEGRVRGEA | IRIRTMKMRQ | QASFLPATLT | MTVDKGDNVN | ISFKKVLIKE |
200:
EDAVIYKNGS | FIHSVPRHEV | PDILEVHLPH | AQPQDAGVYS | ARYIGGNLFT |
250:
SAFTRLIVRR | CEAQKWGPEC | NHLCTACMNN | GVCHEDTGEC | ICPPGFMGRT |
300:
CEKACELHTF | GRTCKERCSG | QEGCKSYVFC | LPDPYGCSCA | TGWKGLQCNE |
350:
ACHPGFYGPD | CKLRCSCNNG | EMCDRFQGCL | CSPGWQGLQC | EREGIQRMTP |
400:
KIVDLPDHIE | VNSGKFNPIC | KASGWPLPTN | EEMTLVKPDG | TVLHPKDFNH |
450:
TDHFSVAIFT | IHRILPPDSG | VWVCSVNTVA | GMVEKPFNIS | VKVLPKPLNA |
500:
PNVIDTGHNF | AVINISSEPY | FGDGPIKSKK | LLYKPVNHYE | AWQHIQVTNE |
550:
IVTLNYLEPR | TEYELCVQLV | RRGEGGEGHP | GPVRRFTTAS | IGLPPPRGLN |
600:
LLPKSQTTLN | LTWQPIFPSS | EDDFYVEVER | RSVQKSDQQN | IKVPGNLTSV |
650:
LLNNLHPREQ | YVVRARVNTK | AQGEWSEDLT | AWTLSDILPP | QPENIKISNI |
700:
THSSAVISWT | ILDGYSISSI | TIRYKVQGKN | EDQHVDVKIK | NATITQYQLK |
750:
GLEPETAYQV | DIFAENNIGS | SNPAFSHELV | TLPESQAPAD | LGGGKMLLIA |
800:
ILGSAGMTCL | TVLLAFLIIL | QLKRANVQRR | MAQAFQNVRE | EPAVQFNSGT |
850:
LALNRKVKNN | PDPTIYPVLD | WNDIKFQDVI | GEGNFGQVLK | ARIKKDGLRM |
900:
DAAIKRMKEY | ASKDDHRDFA | GELEVLCKLG | HHPNIINLLG | ACEHRGYLYL |
950:
AIEYAPHGNL | LDFLRKSRVL | ETDPAFAIAN | STASTLSSQQ | LLHFAADVAR |
1000:
GMDYLSQKQF | IHRDLAARNI | LVGENYVAKI | ADFGLSRGQE | VYVKKTMGRL |
1050:
PVRWMAIESL | NYSVYTTNSD | VWSYGVLLWE | IVSLGGTPYC | GMTCAELYEK |
1100:
LPQGYRLEKP | LNCDDEVYDL | MRQCWREKPY | ERPSFAQILV | SLNRMLEERK |
1124:
TYVNTTLYEK | FTYAGIDCSA | EEAA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Human Angiopoietin-1 receptor
ELISA Kit for Human Angiopoietin-1 receptor
ELISA Kit for Human Angiopoietin-1 receptor
CLIA Kit for Human Angiopoietin-1 receptor
CLIA Kit for Human Angiopoietin-1 receptor
CLIA Kit for Human Angiopoietin-1 receptor
Polyclonal Antibody for Human Angiopoietin-1 receptor
Polyclonal Antibody for Human Angiopoietin-1 receptor
Polyclonal Antibody for Human Angiopoietin-1 receptor
Monoclonal Antibody for Human Angiopoietin-1 receptor
Monoclonal Antibody for Human Angiopoietin-1 receptor
Monoclonal Antibody for Human Angiopoietin-1 receptor
Protein for Human Angiopoietin-1 receptor
Protein for Human Angiopoietin-1 receptor
Protein for Human Angiopoietin-1 receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY;TISSUE SPECIFICITY;VARIANT PRO-346
tissue :
Placenta .
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Nat. Genet.36:40-45(2004)
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT PRO-346
tissue :
Brain .
tissue :
Placenta .
3.
"DNA sequence and analysis of human chromosome 9."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT PRO-346
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-346
tissue :
Pancreas .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 23-37
7.
"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."
Maisonpierre P.C.
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Suri C.
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Jones P.F.
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Bartunkova S.
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Wiegand S.J.
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Radziejewski C.
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Science277:55-60(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS RECEPTOR FOR ANGPT1 AND ANGPT2;INTERACTION WITH ANGPT1 AND ANGPT2;AUTOPHOSPHORYLATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CATALYTIC ACTIVITY;ENZYME REGULATION;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-860; TYR-992 AND TYR-1108
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; ENDOTHELIAL CELL MIGRATION AND REORGANIZATION OF THE ACTIN CYTOSKELETON
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TNIP2;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-855
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1;DOMAIN;INTERACTION WITH ANGPT1; ANGPT2 AND ANGPT4
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS ANGPT1 RECEPTOR IN PHOSPHORYLATION OF SHC1 AND PIK3R1; REGULATION OF CELL MIGRATION AND ANGIOGENESIS;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-1102;PHOSPHORYLATION AT TYR-1102;CATALYTIC ACTIVITY;INTERACTION WITH SHC1
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TIE1;SUBCELLULAR LOCATION;FUNCTION AS RECEPTOR FOR ANGPT1 IN PHOSPHORYLATION OF TIE1;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-855
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS ANGPT1 RECEPTOR IN ACTIVATION OF AKT1 OR MAPK1/ERK2 AND MAPK3/ERK1; REGULATION OF ENDOTHELIAL CELL MIGRATION AND CELL SPREADING;SUBCELLULAR LOCATION
16.
"Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts."
Saharinen P.
,
Eklund L.
,
Miettinen J.
,
Wirkkala R.
,
Anisimov A.
,
Winderlich M.
,
Nottebaum A.
,
Vestweber D.
,
Deutsch U.
,
Koh G.Y.
,
Olsen B.R.
,
Alitalo K.
Nat. Cell Biol.10:527-537(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION AS ANGPT1 RECEPTOR IN ACTIVATION OF AKT1 OR MAPK1/ERK2 AND MAPK3/ERK1; REGULATION OF ENDOTHELIAL CELL MIGRATION AND REGULATION OF FOCAL ADHESION ASSEMBLY;INTERACTION WITH TIE1;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION
17.
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Cited for : PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPRB
18.
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Cited for : INTERACTION WITH CBL;SUBCELLULAR LOCATION;UBIQUITINATION
19.
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Cited for : INTERACTION WITH PTPRB
20.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-596
tissue :
Liver .
21.
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Cited for : FUNCTION AS RECEPTOR FOR ANGPT1 AND ANGPT2 IN ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND AKT1; STIMULATION OF ENDOTHELIAL CELL SURVIVAL AND MIGRATION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION
22.
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Cited for : REVIEW ON FUNCTION; INTERACTION WITH EFFECTOR AND SCAFFOLDING PROTEINS;ROLE IN DISEASE
23.
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Cited for : REVIEW ON SUBCELLULAR LOCATION AND CONTEXT-SPECIFIC SIGNALING
24.
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Cited for : REVIEW
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
26.
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Cited for : REVIEW ON SIGNALING;ENZYME REGULATION;ROLE IN DISEASE
27.
"Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail."
Shewchuk L.M.
,
Hassell A.M.
,
Ellis B.
,
Holmes W.D.
,
Davis R.
,
Horne E.L.
,
Kadwell S.H.
,
McKee D.D.
,
Moore J.T.
Structure8:1105-1113(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 808-1124;ACTIVE SITE;ENZYME REGULATION;PREDICTION OF ATP-BINDING REGION
28.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 23-445 ALONE AND IN COMPLEX WITH ANGPT2;GLYCOSYLATION AT ASN-140;DISULFIDE BONDS
29.
"Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors."
Hodous B.L.
,
Geuns-Meyer S.D.
,
Hughes P.E.
,
Albrecht B.K.
,
Bellon S.
,
Caenepeel S.
,
Cee V.J.
,
Chaffee S.C.
,
Emery M.
,
Fretland J.
,
Gallant P.
,
Gu Y.
,
Johnson R.E.
,
Kim J.L.
,
Long A.M.
,
Morrison M.
,
Olivieri P.R.
,
Patel V.F.
,
Polverino A.
,
Rose P.
,
Wang L.
,
Zhao H.
more...
Bioorg. Med. Chem. Lett.17:2886-2889(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 808-1124 IN COMPLEX WITH TRIAZINE DERIVATIVE;ENZYME REGULATION
30.
"Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor."
Hodous B.L.
,
Geuns-Meyer S.D.
,
Hughes P.E.
,
Albrecht B.K.
,
Bellon S.
,
Bready J.
,
Caenepeel S.
,
Cee V.J.
,
Chaffee S.C.
,
Coxon A.
,
Emery M.
,
Fretland J.
,
Gallant P.
,
Gu Y.
,
Hoffman D.
,
Johnson R.E.
,
Kendall R.
,
Kim J.L.
,
Long A.M.
,
Morrison M.
,
Olivieri P.R.
,
Patel V.F.
,
Polverino A.
,
Rose P.
,
Tempest P.
,
Wang L.
,
Whittington D.A.
,
Zhao H.
more...
J. Med. Chem.50:611-626(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 808-1124 IN COMPLEX WITH TRIAZINE DERIVATIVE;ENZYME REGULATION
31.
"Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo."
Luke R.W.
,
Ballard P.
,
Buttar D.
,
Campbell L.
,
Curwen J.
,
Emery S.C.
,
Griffen A.M.
,
Hassall L.
,
Hayter B.R.
,
Jones C.D.
,
McCoull W.
,
Mellor M.
,
Swain M.L.
,
Tucker J.A.
Bioorg. Med. Chem. Lett.19:6670-6674(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 802-1124 IN COMPLEX WITH THIAZOLOPYRIMIDINE DERIVATIVE;ENZYME REGULATION
32.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 808-1124 IN COMPLEX WITH CEP11207
33.
"Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2."
Vikkula M.
,
Boon L.M.
,
Carraway K.L. III
,
Calvert J.T.
,
Diamonti A.J.
,
Goumnerov B.
,
Pasyk K.A.
,
Marchuk D.A.
,
Warman M.L.
,
Cantley L.C.
,
Mulliken J.B.
,
Olse B.R.
Cell87:1181-1190(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT VMCM TRP-849
34.
"Allelic and locus heterogeneity in inherited venous malformations."
Calvert J.T.
,
Riney T.J.
,
Kontos C.D.
,
Cha E.H.
,
Prieto V.G.
,
Shea C.R.
,
Berg J.N.
,
Nevin N.C.
,
Simpson S.A.
,
Pasyk K.A.
,
Speer M.C.
,
Peters K.G.
,
Marchuk D.A.
Hum. Mol. Genet.8:1279-1289(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS VMCM TRP-849 AND SER-897
35.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] ASN-117
36.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] ASN-117; THR-148; VAL-226; ILE-486; LEU-600; PHE-634; ILE-676; THR-724; ALA-883 AND VAL-1124
37.
"Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects."
Wouters V.
,
Limaye N.
,
Uebelhoer M.
,
Irrthum A.
,
Boon L.M.
,
Mulliken J.B.
,
Enjolras O.
,
Baselga E.
,
Berg J.
,
Dompmartin A.
,
Ivarsson S.A.
,
Kangesu L.
,
Lacassie Y.
,
Murphy J.
,
Teebi A.S.
,
Penington A.
,
Rieu P.
,
Vikkula M.
Eur. J. Hum. Genet.18:414-420(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS VMCM TRP-849; CYS-897; HIS-915; CYS-918; LEU-919; SER-925 AND ASN-1100;CHARACTERIZATION OF VARIANTS VMCM TRP-849; SER-897; HIS-915; CYS-918; LEU-919; SER-925 AND ASN-1100