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Index > Protein center > TEK(Gene name) > Human
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  • TEK (Gene name),
  • Angiopoietin-1 receptor (Protein name ),  TIE2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TEK(TIE2;VMCM;VMCM1);
    Protein name:
    Angiopoietin-1 receptor;
    Alternative:
    p140 TEK;Tyrosine-protein kinase receptor TIE-2(hTIE2);p140 TEK;Tyrosine-protein kinase receptor TIE-2(hTIE2);Tunica interna endothelial cell kinase;Tyrosine-protein kinase receptor TEK;
    CD:
    CD202b;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PTPRB.
    Function:
    This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1124
    Sequence:
    50:
    MDSLASLVLC | GVSLLLSGTV | EGAMDLILIN | SLPLVSDAET | SLTCIASGWR | 
    100:
    PHEPITIGRD | FEALMNQHQD | PLEVTQDVTR | EWAKKVVWKR | EKASKINGAY | 
    150:
    FCEGRVRGEA | IRIRTMKMRQ | QASFLPATLT | MTVDKGDNVN | ISFKKVLIKE | 
    200:
    EDAVIYKNGS | FIHSVPRHEV | PDILEVHLPH | AQPQDAGVYS | ARYIGGNLFT | 
    250:
    SAFTRLIVRR | CEAQKWGPEC | NHLCTACMNN | GVCHEDTGEC | ICPPGFMGRT | 
    300:
    CEKACELHTF | GRTCKERCSG | QEGCKSYVFC | LPDPYGCSCA | TGWKGLQCNE | 
    350:
    ACHPGFYGPD | CKLRCSCNNG | EMCDRFQGCL | CSPGWQGLQC | EREGIQRMTP | 
    400:
    KIVDLPDHIE | VNSGKFNPIC | KASGWPLPTN | EEMTLVKPDG | TVLHPKDFNH | 
    450:
    TDHFSVAIFT | IHRILPPDSG | VWVCSVNTVA | GMVEKPFNIS | VKVLPKPLNA | 
    500:
    PNVIDTGHNF | AVINISSEPY | FGDGPIKSKK | LLYKPVNHYE | AWQHIQVTNE | 
    550:
    IVTLNYLEPR | TEYELCVQLV | RRGEGGEGHP | GPVRRFTTAS | IGLPPPRGLN | 
    600:
    LLPKSQTTLN | LTWQPIFPSS | EDDFYVEVER | RSVQKSDQQN | IKVPGNLTSV | 
    650:
    LLNNLHPREQ | YVVRARVNTK | AQGEWSEDLT | AWTLSDILPP | QPENIKISNI | 
    700:
    THSSAVISWT | ILDGYSISSI | TIRYKVQGKN | EDQHVDVKIK | NATITQYQLK | 
    750:
    GLEPETAYQV | DIFAENNIGS | SNPAFSHELV | TLPESQAPAD | LGGGKMLLIA | 
    800:
    ILGSAGMTCL | TVLLAFLIIL | QLKRANVQRR | MAQAFQNVRE | EPAVQFNSGT | 
    850:
    LALNRKVKNN | PDPTIYPVLD | WNDIKFQDVI | GEGNFGQVLK | ARIKKDGLRM | 
    900:
    DAAIKRMKEY | ASKDDHRDFA | GELEVLCKLG | HHPNIINLLG | ACEHRGYLYL | 
    950:
    AIEYAPHGNL | LDFLRKSRVL | ETDPAFAIAN | STASTLSSQQ | LLHFAADVAR | 
    1000:
    GMDYLSQKQF | IHRDLAARNI | LVGENYVAKI | ADFGLSRGQE | VYVKKTMGRL | 
    1050:
    PVRWMAIESL | NYSVYTTNSD | VWSYGVLLWE | IVSLGGTPYC | GMTCAELYEK | 
    1100:
    LPQGYRLEKP | LNCDDEVYDL | MRQCWREKPY | ERPSFAQILV | SLNRMLEERK | 
    1124:
    TYVNTTLYEK | FTYAGIDCSA | EEAA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    Pfam:
    UniGene:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Angiopoietin-1 receptor
    Cat.:
    E0126h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Angiopoietin-1 receptor
    Cat.:
    E0126m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Angiopoietin-1 receptor
    Cat.:
    E0126b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Angiopoietin-1 receptor
    Cat.:
    U0126m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Angiopoietin-1 receptor
    Cat.:
    U0126h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Angiopoietin-1 receptor
    Cat.:
    U0126b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Angiopoietin-1 receptor
    Cat.:
    P0126Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Angiopoietin-1 receptor
    Polyclonal Antibody for Human Angiopoietin-1 receptor
    Cat.:
    P0126Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Angiopoietin-1 receptor
    Monoclonal Antibody for Human Angiopoietin-1 receptor
    Monoclonal Antibody for Human Angiopoietin-1 receptor
    Protein for Human Angiopoietin-1 receptor
    Protein for Human Angiopoietin-1 receptor
    Protein for Human Angiopoietin-1 receptor

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta."
      Ziegler S.F. , Bird T.A. , Schneringer J.A. , Schooley K.A. , Baum P.R.
      Oncogene8:663-670(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY;TISSUE SPECIFICITY;VARIANT PRO-346
      tissue: Placenta.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3);VARIANT PRO-346
      tissue: Brain.
      tissue: Placenta.
    3. 3.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT PRO-346
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT PRO-346
      tissue: Pancreas.
    6. 6.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-37
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR ANGPT1 AND ANGPT2;INTERACTION WITH ANGPT1 AND ANGPT2;AUTOPHOSPHORYLATION
    8. 8.
      "Identification of a soluble form of the angiopoietin receptor TIE-2 released from endothelial cells and present in human blood."
      Reusch P. , Barleon B. , Weindel K. , Martiny-Baron G. , Godde A. , Siemeister G. , Marme D.
      Angiogenesis4:123-131(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING;TISSUE SPECIFICITY
    9. 9.
      "Mechanistic effects of autophosphorylation on receptor tyrosine kinase catalysis: enzymatic characterization of Tie2 and phospho-Tie2."
      Murray B.W. , Padrique E.S. , Pinko C. , McTigue M.A.
      Biochemistry40:10243-10253(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;ENZYME REGULATION;IDENTIFICATION BY MASS SPECTROMETRY;PHOSPHORYLATION AT TYR-860; TYR-992 AND TYR-1108
    10. 10.
      "Tie-2-dependent activation of RhoA and Rac1 participates in endothelial cell motility triggered by angiopoietin-1."
      Cascone I. , Audero E. , Giraudo E. , Napione L. , Maniero F. , Philips M.R. , Collard J.G. , Serini G. , Bussolino F.
      Blood102:2482-2490(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; ENDOTHELIAL CELL MIGRATION AND REORGANIZATION OF THE ACTIN CYTOSKELETON
    11. 11.
      "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
      Hughes D.P. , Marron M.B. , Brindle N.P.
      Circ. Res.92:630-636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNIP2;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-855
    12. 12.
      "Biological characterization of angiopoietin-3 and angiopoietin-4."
      Lee H.J. , Cho C.H. , Hwang S.J. , Choi H.H. , Kim K.T. , Ahn S.Y. , Kim J.H. , Oh J.L. , Lee G.M. , Koh G.Y.
      FASEB J.18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1;DOMAIN;INTERACTION WITH ANGPT1; ANGPT2 AND ANGPT4
    13. 13.
      "Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells."
      Audero E. , Cascone I. , Maniero F. , Napione L. , Arese M. , Lanfrancone L. , Bussolino F.
      J. Biol. Chem.279:13224-13233(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS ANGPT1 RECEPTOR IN PHOSPHORYLATION OF SHC1 AND PIK3R1; REGULATION OF CELL MIGRATION AND ANGIOGENESIS;AUTOPHOSPHORYLATION;MUTAGENESIS OF TYR-1102;PHOSPHORYLATION AT TYR-1102;CATALYTIC ACTIVITY;INTERACTION WITH SHC1
    14. 14.
      "Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2."
      Saharinen P. , Kerkela K. , Ekman N. , Marron M. , Brindle N. , Lee G.M. , Augustin H. , Koh G.Y. , Alitalo K.
      J. Cell Biol.169:239-243(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIE1;SUBCELLULAR LOCATION;FUNCTION AS RECEPTOR FOR ANGPT1 IN PHOSPHORYLATION OF TIE1;AUTOPHOSPHORYLATION;CATALYTIC ACTIVITY;MUTAGENESIS OF LYS-855
    15. 15.
      "Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1."
      Fukuhara S. , Sako K. , Minami T. , Noda K. , Kim H.Z. , Kodama T. , Shibuya M. , Takakura N. , Koh G.Y. , Mochizuki N.
      Nat. Cell Biol.10:513-526(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS ANGPT1 RECEPTOR IN ACTIVATION OF AKT1 OR MAPK1/ERK2 AND MAPK3/ERK1; REGULATION OF ENDOTHELIAL CELL MIGRATION AND CELL SPREADING;SUBCELLULAR LOCATION
    16. 16.
      "Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts."
      Saharinen P. , Eklund L. , Miettinen J. , Wirkkala R. , Anisimov A. , Winderlich M. , Nottebaum A. , Vestweber D. , Deutsch U. , Koh G.Y. , Olsen B.R. , Alitalo K.
      Nat. Cell Biol.10:527-537(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS ANGPT1 RECEPTOR IN ACTIVATION OF AKT1 OR MAPK1/ERK2 AND MAPK3/ERK1; REGULATION OF ENDOTHELIAL CELL MIGRATION AND REGULATION OF FOCAL ADHESION ASSEMBLY;INTERACTION WITH TIE1;AUTOPHOSPHORYLATION;SUBCELLULAR LOCATION
    17. 17.
      "Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells."
      Yacyshyn O.K. , Lai P.F.H. , Forse K. , Teichert-Kuliszewska K. , Jurasz P. , Stewart D.J.
      Angiogenesis12:25-33(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPRB
    18. 18.
      "Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation."
      Wehrle C. , Van Slyke P. , Dumont D.J.
      Biochem. J.423:375-380(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL;SUBCELLULAR LOCATION;UBIQUITINATION
    19. 19.
      "VE-PTP controls blood vessel development by balancing Tie-2 activity."
      Winderlich M. , Keller L. , Cagna G. , Broermann A. , Kamenyeva O. , Kiefer F. , Deutsch U. , Nottebaum A.F. , Vestweber D.
      J. Cell Biol.185:657-671(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPRB
    20. 20.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-596
      tissue: Liver.
    21. 21.
      "Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium."
      Yuan H.T. , Khankin E.V. , Karumanchi S.A. , Parikh S.M.
      Mol. Cell. Biol.29:2011-2022(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR ANGPT1 AND ANGPT2 IN ACTIVATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND AKT1; STIMULATION OF ENDOTHELIAL CELL SURVIVAL AND MIGRATION;CATALYTIC ACTIVITY;AUTOPHOSPHORYLATION
    22. 22.
      "Tie2: a journey from normal angiogenesis to cancer and beyond."
      Martin V. , Liu D. , Fueyo J. , Gomez-Manzano C.
      Histol. Histopathol.23:773-780(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; INTERACTION WITH EFFECTOR AND SCAFFOLDING PROTEINS;ROLE IN DISEASE
    23. 23.
      "Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1."
      Fukuhara S. , Sako K. , Noda K. , Nagao K. , Miura K. , Mochizuki N.
      Exp. Mol. Med.41:133-139(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SUBCELLULAR LOCATION AND CONTEXT-SPECIFIC SIGNALING
    24. 24.
      "Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
      Augustin H.G. , Koh G.Y. , Thurston G. , Alitalo K.
      Nat. Rev. Mol. Cell Biol.10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
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      "Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis."
      Fukuhara S. , Sako K. , Noda K. , Zhang J. , Minami M. , Mochizuki N.
      Histol. Histopathol.25:387-396(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    26. 26.
      "Targeting the ANGPT-TIE2 pathway in malignancy."
      Huang H. , Bhat A. , Woodnutt G. , Lappe R.
      Nat. Rev. Cancer10:575-585(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON SIGNALING;ENZYME REGULATION;ROLE IN DISEASE
    27. 27.
      "Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail."
      Shewchuk L.M. , Hassell A.M. , Ellis B. , Holmes W.D. , Davis R. , Horne E.L. , Kadwell S.H. , McKee D.D. , Moore J.T.
      Structure8:1105-1113(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 808-1124;ACTIVE SITE;ENZYME REGULATION;PREDICTION OF ATP-BINDING REGION
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      "Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex."
      Barton W.A. , Tzvetkova-Robev D. , Miranda E.P. , Kolev M.V. , Rajashankar K.R. , Himanen J.P. , Nikolov D.B.
      Nat. Struct. Mol. Biol.13:524-532(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 23-445 ALONE AND IN COMPLEX WITH ANGPT2;GLYCOSYLATION AT ASN-140;DISULFIDE BONDS
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 808-1124 IN COMPLEX WITH TRIAZINE DERIVATIVE;ENZYME REGULATION
    30. 30.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 808-1124 IN COMPLEX WITH TRIAZINE DERIVATIVE;ENZYME REGULATION
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      "Novel thienopyrimidine and thiazolopyrimidine kinase inhibitors with activity against Tie-2 in vitro and in vivo."
      Luke R.W. , Ballard P. , Buttar D. , Campbell L. , Curwen J. , Emery S.C. , Griffen A.M. , Hassall L. , Hayter B.R. , Jones C.D. , McCoull W. , Mellor M. , Swain M.L. , Tucker J.A.
      Bioorg. Med. Chem. Lett.19:6670-6674(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 802-1124 IN COMPLEX WITH THIAZOLOPYRIMIDINE DERIVATIVE;ENZYME REGULATION
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      "Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207."
      Fedorov A.A. , Fedorov E.V. , Pauletti D. , Meyer S.L. , Hudkins R.L. , Almo S.C.
      Submitted (2010-01) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 808-1124 IN COMPLEX WITH CEP11207
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      "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2."
      Vikkula M. , Boon L.M. , Carraway K.L. III , Calvert J.T. , Diamonti A.J. , Goumnerov B. , Pasyk K.A. , Marchuk D.A. , Warman M.L. , Cantley L.C. , Mulliken J.B. , Olse B.R.
      Cell87:1181-1190(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VMCM TRP-849
    34. 34.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VMCM TRP-849 AND SER-897
    35. 35.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-117
    36. 36.
      "Patterns of somatic mutation in human cancer genomes."
      Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
      Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ASN-117; THR-148; VAL-226; ILE-486; LEU-600; PHE-634; ILE-676; THR-724; ALA-883 AND VAL-1124
    37. 37.
      "Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects."
      Wouters V. , Limaye N. , Uebelhoer M. , Irrthum A. , Boon L.M. , Mulliken J.B. , Enjolras O. , Baselga E. , Berg J. , Dompmartin A. , Ivarsson S.A. , Kangesu L. , Lacassie Y. , Murphy J. , Teebi A.S. , Penington A. , Rieu P. , Vikkula M.
      Eur. J. Hum. Genet.18:414-420(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VMCM TRP-849; CYS-897; HIS-915; CYS-918; LEU-919; SER-925 AND ASN-1100;CHARACTERIZATION OF VARIANTS VMCM TRP-849; SER-897; HIS-915; CYS-918; LEU-919; SER-925 AND ASN-1100
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