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Index > Protein center > TIMP3(Gene name) > Human
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  • TIMP3 (Gene name),
  • Metalloproteinase inhibitor 3 (Protein name ),  TIMP3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TIMP3;
    Protein name:
    Metalloproteinase inhibitor 3;
    Alternative:
    Tissue inhibitor of metalloproteinases 3(TIMP-3);Protein MIG-5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with EFEMP1.
    Function:
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    211
    Sequence:
    50:
    MTPWLGLIVL | LGSWSLGDWG | AEACTCSPSH | PQDAFCNSDI | VIRAKVVGKK | 
    100:
    LVKEGPFGTL | VYTIKQMKMY | RGFTKMPHVQ | YIHTEASESL | CGLKLEVNKY | 
    150:
    QYLLTGRVYD | GKMYTGLCNF | VERWDQLTLS | QRKGLNYRYH | LGCNCKIKSC | 
    200:
    YYLPCFVTSK | NECLWTDMLS | NFGYPGYQSK | HYACIRQKGG | YCSWYRGWAP | 
    211:
    PDKSIINATD | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    E0129m
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    96T
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    ELISA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    E0129b
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    Packing:
    96T
    ELISA Kit for Human Metalloproteinase inhibitor 3
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    E0129h
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    ELISA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    E0129c
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    96T
    ELISA Kit for Human Metalloproteinase inhibitor 3
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    ELISA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    E0129r
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    Packing:
    96T
    CLIA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    U0129b
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    96T
    CLIA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    U0129h
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    Packing:
    96T
    CLIA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    U0129r
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    Packing:
    96T
    CLIA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    U0129m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Metalloproteinase inhibitor 3
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    CLIA Kit for Human Metalloproteinase inhibitor 3
    Cat.:
    U0129c
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    Packing:
    96T
    Polyclonal Antibody for Human Metalloproteinase inhibitor 3
    Cat.:
    P0129Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Metalloproteinase inhibitor 3
    Polyclonal Antibody for Human Metalloproteinase inhibitor 3
    Cat.:
    P0129Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Metalloproteinase inhibitor 3
    Cat.:
    P0129Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Metalloproteinase inhibitor 3
    Polyclonal Antibody for Human Metalloproteinase inhibitor 3
    Monoclonal Antibody for Human Metalloproteinase inhibitor 3
    Monoclonal Antibody for Human Metalloproteinase inhibitor 3
    Monoclonal Antibody for Human Metalloproteinase inhibitor 3
    Monoclonal Antibody for Human Metalloproteinase inhibitor 3
    Monoclonal Antibody for Human Metalloproteinase inhibitor 3
    Monoclonal Antibody for Human Metalloproteinase inhibitor 3
    Protein for Human Metalloproteinase inhibitor 3
    Protein for Human Metalloproteinase inhibitor 3
    Protein for Human Metalloproteinase inhibitor 3
    Protein for Human Metalloproteinase inhibitor 3
    Protein for Human Metalloproteinase inhibitor 3
    Protein for Human Metalloproteinase inhibitor 3

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    Linearity
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    References
    1. 1.
      "Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family."
      Uria J.A. , Ferrando A.A. , Velasco G. , Freije J.M. , Lopez-Otin C.
      Cancer Res.54:2091-2094(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Mammary carcinoma.
    2. 2.
      "Cloning and characterization of human tissue inhibitor of metalloproteinases-3."
      Wilde C.G. , Hawkins P.R. , Coleman R.T. , Levine W.B. , Delegeane A.M. , Okamoto P.M. , Ito L.Y. , Scott R.W. , Seilhamer J.J.
      DNA Cell Biol.13:711-718(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family."
      Silbiger S.M. , Jacobsen V.L. , Cupples R.L. , Koski R.A.
      Gene141:293-297(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Kidney.
    4. 4.
      "A novel member of human tissue inhibitor of metalloproteinases (TIMP) gene family is regulated during G1 progression, mitogenic stimulation, differentiation, and senescence."
      Wick M. , Buerger C. , Bruesselbach S. , Lucibello F. , Mueller R.
      J. Biol. Chem.269:18953-18960(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3)."
      Stoehr H. , Roomp K. , Felbor U. , Weber B.H.F.
      Genome Res.5:483-487(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "TIMP-3 is expressed in the human retinal pigment epithelium."
      Ruiz A.C. , Brett P. , Bok D.
      Biochem. Biophys. Res. Commun.226:467-474(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    10. 10.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
    13. 13.
      "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22."
      Apte S.S. , Mattei M.-G. , Olsen B.R.
      Genomics19:86-90(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-211
      tissue: Placenta.
    14. 14.
      "Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix."
      Kishnani N.S. , Staskus P.W. , Yang T.-T. , Masiarz F.R. , Hawkes S.P.
      Matrix Biol.14:479-488(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-41
    15. 15.
      "Cloning and partial structure of the gene encoding human tissue inhibitor of metalloproteinases-3."
      Hammani K. , Henriet P.M. , Silbiger S.M. , DeClerck Y.A.
      Gene170:287-288(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 42-211
      tissue: Placenta.
    16. 16.
      "Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations."
      Klenotic P.A. , Munier F.L. , Marmorstein L.Y. , Anand-Apte B.
      J. Biol. Chem.279:30469-30473(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EFEMP1
    17. 17.
      "Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex."
      Wisniewska M. , Goettig P. , Maskos K. , Belouski E. , Winters D. , Hecht R. , Black R. , Bode W.
      J. Mol. Biol.381:1307-1319(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 24-144 IN COMPLEX WITH TACE;DISULFIDE BONDS
    18. 18.
      "Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy."
      Weber B.H.F. , Vogt G. , Pruett R.C. , Stoehr H. , Felbor U.
      Nat. Genet.8:352-356(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SFD CYS-191 AND CYS-204
    19. 19.
      "A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features."
      Felbor U. , Stoehr H. , Amann T. , Schoenherr U. , Weber B.H.F.
      Hum. Mol. Genet.4:2415-2416(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SFD CYS-179
    20. 20.
      "Night blindness in Sorsby's fundus dystrophy reversed by vitamin A."
      Jacobson S.G. , Cideciyan A.V. , Regunath G. , Rodriguez F.J. , Vandenburgh K. , Sheffield V.C. , Stone E.M.
      Nat. Genet.11:27-32(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SFD CYS-190
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      "A second independent Tyr168Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy."
      Felbor U. , Stoehr H. , Amann T. , Schoenherr U. , Apfelstedt-Sylla E. , Weber B.H.F.
      J. Med. Genet.33:233-236(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SFD CYS-191
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      "Autosomal recessive Sorsby fundus dystrophy revisited: molecular evidence for dominant inheritance."
      Felbor U. , Suvanto E.A. , Forsius H.R. , Eriksson A.W. , Weber B.H.
      Am. J. Hum. Genet.60:57-62(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SFD CYS-189
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