TLR2 ELISA Kit for Human(Homo sapiens) | EIAab.comTLR2 ELISA Kit for Human(Homo sapiens)

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TLR2 (Gene name),

Toll-like receptor 2 (Protein name ), TLR2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

TLR2(TIL4);

Protein name:

Toll-like receptor 2;

Alternative:

Toll/interleukin-1 receptor-like protein 4;

CD:

CD282;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3.

Function:

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

784

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

784:

KLRKIMNTKT | YLEWPMDEAQ | REGFWVNLRA | AIKS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O60603

MIM:

246300

KEGG:

hsa:7097

STRING:

9606.ENSP00000260010

SMR:

O60603

Pfam:

PF01582

Pfam:

PF00560

UniGene:

Hs.519033

Uniprot:

O60603

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ELISA Kit for Human Toll-like receptor 2

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E0663h

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96T

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ELISA Kit for Human Toll-like receptor 2

Cat.:

E0663m

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96T

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ELISA Kit for Human Toll-like receptor 2

Cat.:

E0663d

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96T

ELISA Kit for Human Toll-like receptor 2

Cat.:

E0663b

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96T

CLIA Kit for Human Toll-like receptor 2

Cat.:

U0663b

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96T

CLIA Kit for Human Toll-like receptor 2

Cat.:

U0663d

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96T

CLIA Kit for Human Toll-like receptor 2

Cat.:

U0663m

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Packing:

96T

CLIA Kit for Human Toll-like receptor 2

Cat.:

U0663h

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96T

Polyclonal Antibody for Human Toll-like receptor 2

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P0663Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Toll-like receptor 2

Cat.:

P0663Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Toll-like receptor 2

Monoclonal Antibody for Human Toll-like receptor 2

Protein for Human Toll-like receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Assessment of TLR-2 concentration in tick-borne encephalitis and neuroborreliosis"

P Penza, P Czupryna, O Zajkowska, et al.

From:Scandinavian Journal of Clinical and Laboratory Investigation

[2].

"Development of a Porcine Bladder Acellular Matrix with Well-Preserved Extracellular Bioactive Factors for Tissue Engineering"

Bin Yang, Yifen Zhang, Liuhua Zhou, Zeyu Sun,Junhua Zheng, Yun Chen, and Yutian Dai,

From:TISSUE ENGINEERING

References

1.

"Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans."
Chaudhary P.M. , Ferguson C. , Nguyen V. , Nguyen O. , Massa H.F. , Eby M. , Jasmin A. , Trask B.J. , Hood L. , Nelson P.S.
Blood91:4020-4027(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Leukocyte.
tissue: Prostate.
2.

"A family of human receptors structurally related to Drosophila Toll."
Rock F.L. , Hardiman G. , Timans J.C. , Kastelein R.A. , Bazan J.F.
Proc. Natl. Acad. Sci. U.S.A.95:588-593(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling."
Yang R.-B. , Mark M.R. , Gray A.M. , Huang A. , Xie M.-H. , Zhang M. , Goddard A.D. , Wood W.I. , Gurney A.L. , Godowski P.J.
Nature395:284-288(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];RESPONSE TO LIPOPOLYSACCHARIDE
tissue: Fetal lung.
4.

"Natural selection in the TLR-related genes in the course of primate evolution."
Nakajima T. , Ohtani H. , Satta Y. , Uno Y. , Akari H. , Ishida T. , Kimura A.
Immunogenetics60:727-735(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
Georgel P. , Macquin C. , Bahram S.
PLoS ONE4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS HIS-631 AND GLN-753
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Blood.
8.

"Cloning and sequencing of extracellular domain and its N-terminal and C-terminal fragments of Toll-like receptor 2."
Zhang L. , Yu W.B. , Ma Y.Y.
Di 4 Jun Yi Da Xue Xue Bao23:1085-1089(2002)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-586
9.

"Cell activation and apoptosis by bacterial lipoproteins through Toll-like receptor-2."
Aliprantis A.O. , Yang R.-B. , Mark M.R. , Suggett S. , Devaux B. , Radolf J.D. , Klimpel G.R. , Godowski P.J. , Zychlinsky A.
Science285:736-739(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RESPONSE TO BACTERIAL LIPOPROTEINS
10.

"A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling."
Yamamoto M. , Sato S. , Mori K. , Hoshino K. , Takeuchi O. , Takeda K. , Akira S.
J. Immunol.169:6668-6672(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TICAM1
11.

"Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion."
Weber A.N. , Morse M.A. , Gay N.J.
J. Biol. Chem.279:34589-34594(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-114; ASN-199 AND ASN-442;MUTAGENESIS OF ASN-114; ASN-199; THR-416 AND ASN-442
12.

"TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3."
Boada-Romero E. , Letek M. , Fleischer A. , Pallauf K. , Ramon-Barros C. , Pimentel-Muinos F.X.
EMBO J.32:566-582(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG16L1
13.

"Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."
Xu Y. , Tao X. , Shen B. , Horng T. , Medzhitov R. , Manley J.L. , Tong L.
Nature408:111-115(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 639-784;MUTAGENESIS
14.

"Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide."
Jin M.S. , Kim S.E. , Heo J.Y. , Lee M.E. , Kim H.M. , Paik S.-G. , Lee H. , Lee J.-O.
Cell130:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-509 IN COMPLEX WITH TLR1 AND BACTERIAL LIPOPEPTIDE ANALOG;DISULFIDE BONDS;GLYCOSYLATION AT ASN-114; ASN-199; ASN-414 AND ASN-442
15.

"Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients."
Kang T.-J. , Chae G.-T.
FEMS Immunol. Med. Microbiol.31:53-58(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-677;ASSOCIATION WITH LEPROSIS
16.

"A Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling."
Bochud P.-Y. , Hawn T.R. , Aderem A.
J. Immunol.170:3451-3454(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-677;ASSOCIATION WITH LEPROSIS
17.

"Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
Ben-Ali M. , Corre B. , Manry J. , Barreiro L.B. , Quach H. , Boniotto M. , Pellegrini S. , Quintana-Murci L.
Hum. Mutat.32:643-652(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-89; ILE-411; HIS-571; HIS-631; ARG-636 AND GLN-753;CHARACTERIZATION OF VARIANTS ILE-411; HIS-631 AND GLN-753

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