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Index > Protein center > TNFSF11(Gene name) > Human
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  • TNFSF11 (Gene name),
  • Tumor necrosis factor ligand superfamily member 11 (Protein name ),  TNF11_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TNFSF11(OPGL;RANKL;TRANCE);
    Protein name:
    Tumor necrosis factor ligand superfamily member 11;
    Alternative:
    TNF-related activation-induced cytokine(TRANCE);Receptor activator of nuclear factor kappa-B ligand(RANKL);Osteoclast differentiation factor(ODF);Osteoprotegerin ligand(OPGL);
    CD:
    CD254;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer.
    Function:
    Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
    Subcellular Location:
    Tumor necrosis factor ligand superfamily member 11, soluble form Secreted
    Protein Attributes:
    Sequence length:
    317
    Sequence:
    50:
    MRRASRDYTK | YLRGSEEMGG | GPGAPHEGPL | HAPPPPAPHQ | PPAASRSMFV | 
    100:
    ALLGLGLGQV | VCSVALFFYF | RAQMDPNRIS | EDGTHCIYRI | LRLHENADFQ | 
    150:
    DTTLESQDTK | LIPDSCRRIK | QAFQGAVQKE | LQHIVGSQHI | RAEKAMVDGS | 
    200:
    WLDLAKRSKL | EAQPFAHLTI | NATDIPSGSH | KVSLSSWYHD | RGWAKISNMT | 
    250:
    FSNGKLIVNQ | DGFYYLYANI | CFRHHETSGD | LATEYLQLMV | YVTKTSIKIP | 
    300:
    SSHTLMKGGS | TKYWSGNSEF | HFYSINVGGF | FKLRSGEEIS | IEVSNPSLLD | 
    317:
    PDQDATYFGA | FKVRDID
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    UniGene:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    E0855r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    E0855m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    E0855h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    U0855h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    U0855m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    U0855r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    P0855Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    P0855Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
    Cat.:
    P0855Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
    Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
    Protein for Human Tumor necrosis factor ligand superfamily member 11
    Protein for Human Tumor necrosis factor ligand superfamily member 11
    Protein for Human Tumor necrosis factor ligand superfamily member 11

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."
      Anderson D.M. , Maraskovsky E. , Billingsley W.L. , Dougall W.C. , Tometsko M.E. , Roux E.R. , Teepe M.C. , DuBose R.F. , Cosman D. , Galibert L.
      Nature390:175-179(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Bone marrow.
      tissue: Peripheral blood.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Lymph node.
    3. 3.
      "Determination of human RANKL isoforms."
      Ikeda T. , Kuroyama H. , Hirokawa K.
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
    4. 4.
      "Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation."
      Nagai M. , Kyakumoto S. , Sato N.
      Biochem. Biophys. Res. Commun.269:532-536(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Tongue.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    6. 6.
      "TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells."
      Wong B.R. , Rho J. , Arron J. , Robinson E. , Orlinick J. , Chao M. , Kalachikov S. , Cayani E. , Bartlett F.S. III , Frankel W.N. , Lee S.Y. , Choi Y.
      J. Biol. Chem.272:25190-25194(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-317
      tissue: Thymocyte.
    7. 7.
      "Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin."
      Luan X. , Lu Q. , Jiang Y. , Zhang S. , Wang Q. , Yuan H. , Zhao W. , Wang J. , Wang X.
      J. Immunol.189:245-252(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 162-317 IN COMPLEX WITH TNFRSF11B;FUNCTION;MUTAGENESIS OF ARG-223 AND LYS-257;INTERACTION WITH TNFRSF11B
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OPTB2 LYS-199
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