Gene name:
TNFSF11 (OPGL;RANKL;TRANCE) ;
Protein name:
Tumor necrosis factor ligand superfamily member 11 ;
Alternative:
Osteoprotegerin ligand (OPGL) ;Osteoclast differentiation factor (ODF) ;TNF-related activation-induced cytokine (TRANCE) ;Receptor activator of nuclear factor kappa-B ligand (RANKL) ;
CD:
CD254 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.
Subcellular Location:
Tumor necrosis factor ligand superfamily member 11, soluble form
Secreted
Protein Attributes:
50:
MRRASRDYTK | YLRGSEEMGG | GPGAPHEGPL | HAPPPPAPHQ | PPAASRSMFV |
100:
ALLGLGLGQV | VCSVALFFYF | RAQMDPNRIS | EDGTHCIYRI | LRLHENADFQ |
150:
DTTLESQDTK | LIPDSCRRIK | QAFQGAVQKE | LQHIVGSQHI | RAEKAMVDGS |
200:
WLDLAKRSKL | EAQPFAHLTI | NATDIPSGSH | KVSLSSWYHD | RGWAKISNMT |
250:
FSNGKLIVNQ | DGFYYLYANI | CFRHHETSGD | LATEYLQLMV | YVTKTSIKIP |
300:
SSHTLMKGGS | TKYWSGNSEF | HFYSINVGGF | FKLRSGEEIS | IEVSNPSLLD |
317:
PDQDATYFGA | FKVRDID
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 11
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 11
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 11
Protein for Human Tumor necrosis factor ligand superfamily member 11
Protein for Human Tumor necrosis factor ligand superfamily member 11
Protein for Human Tumor necrosis factor ligand superfamily member 11
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Victoria Clérigues, Maria Isabel Guillén, Miguel Angel Castejón, Francisco Gomard, Vicente Mirabete, Maria José Alcaraz
[2].
Sun Kyoung Lee, Kwang-Kyun Park, Jung Han Yoon Park, Soon Sung Lim, Won-Yoon Chung
[3].
SK Lee, KK Park, JHY Park, et al.
[4].
Lee S K, Park K K, Kim K R, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Bone marrow .
tissue :
Peripheral blood .
2.
"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Lymph node .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Tongue .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lung .
6.
"TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells."
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7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 162-317 IN COMPLEX WITH TNFRSF11B;FUNCTION;MUTAGENESIS OF ARG-223 AND LYS-257;INTERACTION WITH TNFRSF11B
8.
"Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL."
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Frattini A.
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Guerrini M.M.
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Pangrazio A.
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Nat. Genet.39:960-962(2007)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT OPTB2 LYS-199