TNFSF12 ELISA Kit for Human(Homo sapiens) | EIAab.comTNFSF12 ELISA Kit for Human(Homo sapiens)

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TNFSF12 (Gene name),

Tumor necrosis factor ligand superfamily member 12 (Protein name ), TNF12_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TNFSF12(UNQ181/PRO207;APO3L;DR3LG);

Protein name:

Tumor necrosis factor ligand superfamily member 12;

Alternative:

TNF-related weak inducer of apoptosis(TWEAK);APO3 ligand;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q.

Function:

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.

Subcellular Location:

Tumor necrosis factor ligand superfamily member 12, secreted form Secreted

Protein Attributes:

Sequence length:

249

Sequence:

50:

100:

150:

200:

249:

SSLGPQLRLC | QVSGLLALRP | GSSLRIRTLP | WAHLKAAPFL | TYFGLFQVH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O43508

Pfam:

PF00229

UniGene:

Hs.54673

KEGG:

hsa:8742

KEGG:

hsa:407977

String:

O43508

MIM:

602695

STRING:

9606.ENSP00000293826

Uniprot:

O43508

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ELISA Kit for Human Tumor necrosis factor ligand superfamily member 12

Cat.:

E1883h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Tumor necrosis factor ligand superfamily member 12

Cat.:

E1883m

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MSDS:

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Packing:

96T

CLIA Kit for Human Tumor necrosis factor ligand superfamily member 12

Cat.:

U1883m

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MSDS:

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Packing:

96T

CLIA Kit for Human Tumor necrosis factor ligand superfamily member 12

Cat.:

U1883h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 12

Cat.:

P1883Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 12

Cat.:

P1883Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 12

Protein for Human Tumor necrosis factor ligand superfamily member 12

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis."
Chicheportiche Y. , Bourdon P.R. , Xu H. , Hsu Y.-M. , Scott H. , Hession C. , Garcia I. , Browning J.L.
J. Biol. Chem.272:32401-32410(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);N-TERMINUS OF SOLUBLE FORM
tissue: Fetal liver.
tissue: Tonsil.
2.

"Identification of a ligand for the death-domain-containing receptor Apo3."
Marsters S.A. , Sheridan J.P. , Pitti R.M. , Brush J. , Goddard A. , Ashkenazi A.
Curr. Biol.8:525-528(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal kidney.
3.

"An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein."
Pradet-Balade B. , Medema J.P. , Lopez-Fraga M. , Lozano J.C. , Kolfschoten G.M. , Picard A. , Martinez-A C. , Garcia-Sanz J.A. , Hahne M.
EMBO J.21:5711-5720(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM TWE-PRIL);SUBCELLULAR LOCATION
4.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Tonsil.
7.

"TWEAK induces angiogenesis and proliferation of endothelial cells."
Lynch C.N. , Wang Y.C. , Lund J.K. , Chen Y.-W. , Leal J.A. , Wiley S.R.
J. Biol. Chem.274:8455-8459(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome."
Tian X.-L. , Kadaba R. , You S.-A. , Liu M. , Timur A.A. , Yang L. , Chen Q. , Szafranski P. , Rao S. , Wu L. , Housman D.E. , DiCorleto P.E. , Driscoll D.J. , Borrow J. , Wang Q.
Nature427:640-645(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AGGF1/VG5Q
9.

"TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor."
Wiley S.R. , Winkles J.A.
Cytokine Growth Factor Rev.14:241-249(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
10.

"Crystal structure of human TWEAK in complex with the Fab fragment of a neutralizing antibody reveals insights into receptor binding."
Lammens A. , Baehner M. , Kohnert U. , Niewoehner J. , von Proff L. , Schraeml M. , Lammens K. , Hopfner K.P.
PLoS ONE8:E62697-E62697(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 97-249 IN COMPLEX WITH THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY;FUNCTION;SUBUNIT;DISULFIDE BOND

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