Lymphotoxin-alpha (Protein name
), TNFB_CANFA from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
LTA(TNFB;TNFSF1);
Protein name:
Lymphotoxin-alpha(LT-alpha);
Alternative:
Tumor necrosis factor ligand superfamily member 1;TNF-beta;
Organism:
Dog (Canis familiarisCanis lupus familiaris).
General Annotation
Sub Unit:
Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
Function:
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular Location:
Secreted
Membrane
The homotrimer is secreted (By similarity). The heterotrimer is membrane-associated.
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Precision
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Recovery
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Linearity
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References
1.
"Gemomic map of a portion of the canine MHC class I histocompatibility complex." Wagner J.L.
,
Palti Y.
,
DiDario D.D.
Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]