Gene name:
FASLG (APT1LG1;CD95L;FASL;TNFSF6) ;
Protein name:
Tumor necrosis factor ligand superfamily member 6 ;
Alternative:
CD95 ligand (CD95-L) ;Apoptosis antigen ligand (APTL) ;Fas antigen ligand (Fas ligand) ;
CD:
CD178 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotrimer (Probable). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.
Function:
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Secreted
Cytoplasmic vesicle lumen
Lysosome lumen
May be released into the extracellular fluid, probably by cleavage form the cell surface. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination.
Protein Attributes:
50:
MQQPFNYPYP | QIYWVDSSAS | SPWAPPGTVL | PCPTSVPRRP | GQRRPPPPPP |
100:
PPPLPPPPPP | PPLPPLPLPP | LKKRGNHSTG | LCLLVMFFMV | LVALVGLGLG |
150:
MFQLFHLQKE | LAELRESTSQ | MHTASSLEKQ | IGHPSPPPEK | KELRKVAHLT |
200:
GKSNSRSMPL | EWEDTYGIVL | LSGVKYKKGG | LVINETGLYF | VYSKVYFRGQ |
250:
SCNNLPLSHK | VYMRNSKYPQ | DLVMMEGKMM | SYCTTGQMWA | RSSYLGAVFN |
281:
LTSADHLYVN | VSELSLVNFE | ESQTFFGLYK | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Pig
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
ELISA Kit for Human Tumor necrosis factor ligand superfamily member 6
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
CLIA Kit for Human Tumor necrosis factor ligand superfamily member 6
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Polyclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Monoclonal Antibody for Human Tumor necrosis factor ligand superfamily member 6
Protein for Human Tumor necrosis factor ligand superfamily member 6
Protein for Human Tumor necrosis factor ligand superfamily member 6
Protein for Human Tumor necrosis factor ligand superfamily member 6
Protein for Human Tumor necrosis factor ligand superfamily member 6
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Leukocyte .
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more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Blood .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10
tissue :
Blood .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN ALPS1B
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION;MUTAGENESIS OF PRO-206; TYR-218 AND PHE-275
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC PROCESSING
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Cell Death Differ.14:1678-1687(2007)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION OF FASL INTRACELLULAR DOMAIN;CLEAVAGE BY ADAM10 AND SPPL2A;SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;PHOSPHORYLATION;INTERACTION WITH FGR; FYN AND LYN;SUBCELLULAR LOCATION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ARHGAP9; BAIAP2L1; BTK; CACNB3; CACNB4; CRK; DLG2; DNMBP; DOCK4; EPS8L3; FYB; FYN; HCK; ITK; ITSN2; KALRN; LYN; MACC1; MIA; MPP4; MYO15A; NCF1; NCK1; NCK2; NCKIPSD; OSTF1; PIK3R1; PSTPIP1; RIMBP3C; SAMSN1; SH3GL3; SH3PXD2B; SH3PXD2A; SH3RF2; SKAP2; SNX33; SNX9; SORBS3; SPTA1; SRC; SRGAP1; SRGAP2; SRGAP3; TEC; TJP3 AND YES1