NGFR ELISA Kit for Human(Homo sapiens) | EIAab.comNGFR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NGFR(Gene name) > Human

NGFR (Gene name),

Tumor necrosis factor receptor superfamily member 16 (Protein name ), TNR16_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NGFR(TNFRSF16);

Protein name:

Tumor necrosis factor receptor superfamily member 16;

Alternative:

Low affinity neurotrophin receptor p75NTR;Gp80-LNGFR;p75 ICD;Low-affinity nerve growth factor receptor(NGF receptor);

CD:

CD271;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1.

Function:

Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

427

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

427:

LLAALRRIQR | ADLVESLCSE | STATSPV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P08138

KEGG:

hsa:4804

MIM:

162010

UniGene:

Hs.415768

Pfam:

PF00531

STRING:

9606.ENSP00000172229

String:

P08138

Uniprot:

P08138

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

E9231r

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Manual:

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96T

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

E9231c

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96T

ELISA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

E9231m

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96T

ELISA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

E9231h

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96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

U9231r

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MSDS:

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Packing:

96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

U9231m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

U9231h

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MSDS:

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Packing:

96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

U9231c

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

P9231Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

P9231Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 16

Cat.:

P9231Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 16

Protein for Human Tumor necrosis factor receptor superfamily member 16

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Expression and structure of the human NGF receptor."
Johnson D. , Lanahan A. , Buck C.R. , Sehgal A. , Morgan C. , Mercer E. , Bothwell M. , Chao M.
Cell47:545-554(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Cerebellum.
tissue: Thymus.
3.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
6.

"A constitutive promoter directs expression of the nerve growth factor receptor gene."
Sehgal A. , Patil N. , Chao M.
Mol. Cell. Biol.8:3160-3167(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
7.

"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction."
Ye X. , Mehlen P. , Rabizadeh S. , VanArsdale T. , Zhang H. , Shin H. , Wang J.J.L. , Leo E. , Zapata J.M. , Hauser C.A. , Reed J.C. , Bredesen D.E.
J. Biol. Chem.274:30202-30208(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF2; TRAF4 AND TRAF6
8.

"Association of the p75 neurotrophin receptor with TRAF6."
Khursigara G. , Orlinick J.R. , Chao M.V.
J. Biol. Chem.274:2597-2600(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF6
9.

"Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation."
Irie S. , Hachiya T. , Rabizadeh S. , Maruyama W. , Mukai J. , Li Y. , Reed J.C. , Bredesen D.E. , Sato T.A.
FEBS Lett.460:191-198(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN13
10.

"The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor."
Wooten M.W. , Seibenhener M.L. , Mamidipudi V. , Diaz-Meco M.T. , Barker P.A. , Moscat J.
J. Biol. Chem.276:7709-7712(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRAF6 AND SQSTM1
11.

"RanBPM is a novel binding protein for p75NTR."
Bai D. , Chen H. , Huang B.-R.
Biochem. Biophys. Res. Commun.309:552-557(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RANBP9
tissue: Brain.
12.

"LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex."
Mi S. , Lee X. , Shao Z. , Thill G. , Ji B. , Relton J. , Levesque M. , Allaire N. , Perrin S. , Sands B. , Crowell T. , Cate R.L. , McCoy J.M. , Pepinsky R.B.
Nat. Neurosci.7:221-228(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH LINGO1
13.

"O-linked oligosaccharide on the 75-kDa neurotrophin receptor."
Chapman B.S. , Eckart M.R. , Kaufman S.E. , Lapointe G.R.
J. Neurochem.66:1707-1716(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF O-LINKED CARBOHYDRATE
14.

"p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
Baeza-Raja B. , Eckel-Mahan K. , Zhang L. , Vagena E. , Tsigelny I.F. , Sassone-Corsi P. , Ptacek L.J. , Akassoglou K.
J. Neurosci.33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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