Gene name:
Ngfr (Tnfrsf16) ;
Protein name:
Tumor necrosis factor receptor superfamily member 16 ;
Alternative:
Low-affinity nerve growth factor receptor (NGF receptor) ;Low affinity neurotrophin receptor p75NTR ;
CD:
CD271 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts with BEX1. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1.
Function:
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells (By similarity). Binds to rabies virus glycoprotein Gs.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MDRLRLLLLL | LLLLGVSFGG | AKETCSTGMY | THSGECCKAC | NLGEGVAQPC |
100:
GANQTVCEPC | LDSVTFSDVV | SATEPCKPCT | ECLGLQSMSA | PCVEADDAVC |
150:
RCSYGYYQDE | ETGRCEACSV | CGVGSGLVFS | CQDKQNTVCE | ECPEGTYSDE |
200:
ANHVDPCLPC | TVCEDTERQL | RECTPWADAE | CEEIPGRWIT | RSTPPEGSDV |
250:
TTPSTQEPEA | PPERDLIAST | VADTVTTVMG | SSQPVVTRGT | ADNLIPVYCS |
300:
ILAAVVVGLV | AYIAFKRWNS | CKQNKQGANS | RPVNQTPPPE | GEKLHSDSGI |
350:
SVDSQSLHDQ | QTHTQTASAQ | ALKGDGNLYS | SLPLTKREEV | EKLLNGDTWR |
400:
HLAGELGYQP | EHIDSFTHEA | CPVRALLASW | GAQDSATLDA | LLAALRRIQR |
417:
ADIVESLCSE | STATSPV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Mouse
Human
ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
ELISA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
CLIA Kit for Mouse Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Polyclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Monoclonal Antibody for Mouse Tumor necrosis factor receptor superfamily member 16
Protein for Mouse Tumor necrosis factor receptor superfamily member 16
Protein for Mouse Tumor necrosis factor receptor superfamily member 16
Protein for Mouse Tumor necrosis factor receptor superfamily member 16
Protein for Mouse Tumor necrosis factor receptor superfamily member 16
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
A .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NGFRAP1
3.
"p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity."
Baeza-Raja B.
,
Li P.
,
Le Moan N.
,
Sachs B.D.
,
Schachtrup C.
,
Davalos D.
,
Vagena E.
,
Bridges D.
,
Kim C.
,
Saltiel A.R.
,
Olefsky J.M.
,
Akassoglou K.
Proc. Natl. Acad. Sci. U.S.A.109:5838-5843(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH RAB31
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION