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Index > Protein center > Ngfr(Gene name) > Rat
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  • Ngfr (Gene name),
  • Tumor necrosis factor receptor superfamily member 16 (Protein name ),  TNR16_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ngfr(Tnfrsf16);
    Protein name:
    Tumor necrosis factor receptor superfamily member 16;
    Alternative:
    Low affinity neurotrophin receptor p75NTR;Gp80-LNGFR;p75 ICD;Low-affinity nerve growth factor receptor(NGF receptor);
    CD:
    CD271;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (By similarity). Interacts with BEX1. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
    Function:
    Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    425
    Sequence:
    50:
    MRRAGAACSA | MDRLRLLLLL | ILGVSSGGAK | ETCSTGLYTH | SGECCKACNL | 
    100:
    GEGVAQPCGA | NQTVCEPCLD | NVTFSDVVSA | TEPCKPCTEC | LGLQSMSAPC | 
    150:
    VEADDAVCRC | AYGYYQDEET | GHCEACSVCE | VGSGLVFSCQ | DKQNTVCEEC | 
    200:
    PEGTYSDEAN | HVDPCLPCTV | CEDTERQLRE | CTPWADAECE | EIPGRWIPRS | 
    250:
    TPPEGSDSTA | PSTQEPEVPP | EQDLVPSTVA | DMVTTVMGSS | QPVVTRGTTD | 
    300:
    NLIPVYCSIL | AAVVVGLVAY | IAFKRWNSCK | QNKQGANSRP | VNQTPPPEGE | 
    350:
    KLHSDSGISV | DSQSLHDQQT | HTQTASGQAL | KGDGNLYSSL | PLTKREEVEK | 
    400:
    LLNGDTWRHL | AGELGYQPEH | IDSFTHEACP | VRALLASWGA | QDSATLDALL | 
    425:
    AALRRIQRAD | IVESLCSEST | ATSPV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    E9231r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    E9231c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    E9231m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    E9231h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    U9231r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    U9231m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    U9231h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    U9231c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    P9231Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    P9231Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Polyclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Cat.:
    P9231Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Monoclonal Antibody for Rat Tumor necrosis factor receptor superfamily member 16
    Protein for Rat Tumor necrosis factor receptor superfamily member 16
    Protein for Rat Tumor necrosis factor receptor superfamily member 16
    Protein for Rat Tumor necrosis factor receptor superfamily member 16
    Protein for Rat Tumor necrosis factor receptor superfamily member 16

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    References
    1. 1.
      "Gene transfer and molecular cloning of the rat nerve growth factor receptor."
      Radeke M.J. , Misko T.P. , Hsu C. , Herzenberg L.A. , Shooter E.M.
      Nature325:593-597(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter."
      Metsis M. , Timmusk T. , Allikmets R. , Saarma M. , Persson H.
      Gene121:247-254(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
      tissue: Liver.
    3. 3.
      "Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR."
      Bibel M. , Hoppe E. , Barde Y.A.
      EMBO J.18:616-622(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NTRK2
    4. 4.
      "NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis."
      Salehi A.H. , Roux P.P. , Kubu C.J. , Zeindler C. , Bhakar A. , Tannis L.-L. , Verdi J.M. , Barker P.A.
      Neuron27:279-288(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;INTERACTION WITH MAGED1
      strain: Sprague-Dawley.
      tissue: Neural crest.
    5. 5.
      "An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors."
      Kong H. , Boulter J. , Weber J.L. , Lai C. , Chao M.V.
      J. Neurosci.21:176-185(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIDINS220
    6. 6.
      "PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor."
      Frankowski H. , Castro-Obregon S. , del Rio G. , Rao R.V. , Bredesen D.E.
      NeuroMolecular Med.1:153-170(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NRADD
    7. 7.
      "Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein."
      Chang M.-S. , Arevalo J.C. , Chao M.V.
      J. Neurosci. Res.78:186-192(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NTRK1 AND KIDINS220;DOMAIN
    8. 8.
      "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle."
      Vilar M. , Murillo-Carretero M. , Mira H. , Magnusson K. , Besset V. , Ibanez C.F.
      EMBO J.25:1219-1230(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BEX1
    9. 9.
      "NMR structure of the death domain of the p75 neurotrophin receptor."
      Liepinsh E. , Ilag L.L. , Otting G. , Ibanez C.F.
      EMBO J.16:4999-5005(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 334-418
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