Gene name:
TNFRSF1B (TNFBR;TNFR2) ;
Protein name:
Tumor necrosis factor receptor superfamily member 1B ;
Alternative:
Tumor necrosis factor receptor type II (TNF-RII;TNFR-II) ;Tumor necrosis factor receptor 2 (TNF-R2) ;p80 TNF-alpha receptor ;p75 ;
CD:
CD120b ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds to TRAF2. Interacts with BMX.
Function:
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
Subcellular Location:
Tumor necrosis factor-binding protein 2
Secreted
Protein Attributes:
50:
MAPVAVWAAL | AVGLELWAAA | HALPAQVAFT | PYAPEPGSTC | RLREYYDQTA |
100:
QMCCSKCSPG | QHAKVFCTKT | SDTVCDSCED | STYTQLWNWV | PECLSCGSRC |
150:
SSDQVETQAC | TREQNRICTC | RPGWYCALSK | QEGCRLCAPL | RKCRPGFGVA |
200:
RPGTETSDVV | CKPCAPGTFS | NTTSSTDICR | PHQICNVVAI | PGNASMDAVC |
250:
TSTSPTRSMA | PGAVHLPQPV | STRSQHTQPT | PEPSTAPSTS | FLLPMGPSPP |
300:
AEGSTGDFAL | PVGLIVGVTA | LGLLIIGVVN | CVIMTQVKKK | PLCLQREAKV |
350:
PHLPADKARG | TQGPEQQHLL | ITAPSSSSSS | LESSASALDR | RAPTRNQPQA |
400:
PGVEASGAGE | ARASTGSSDS | SPGGHGTQVN | VTCIVNVCSS | SDHSSQCSSQ |
450:
ASSTMGDTDS | SPSESPKDEQ | VPFSKEECAF | RSQLETPETL | LGSTEEKPLP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B
ELISA Kit for Human Tumor necrosis factor receptor superfamily member 1B
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B
CLIA Kit for Human Tumor necrosis factor receptor superfamily member 1B
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 1B
Protein for Human Tumor necrosis factor receptor superfamily member 1B
Protein for Human Tumor necrosis factor receptor superfamily member 1B
Protein for Human Tumor necrosis factor receptor superfamily member 1B
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Klaus F. Hofmann-Kiefer, D. Chappell, J. Knabl,H.G. Frank, N. Martinoff, P. Conzen, B.F. Becker, M. Rehm
[2].
Wang Z L, Gao S, Li L, et al
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