TNFRSF10B ELISA Kit for Human(Homo sapiens) | EIAab.comTNFRSF10B ELISA Kit for Human(Homo sapiens)

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Index > Protein center > TNFRSF10B(Gene name) > Human

TNFRSF10B (Gene name),

Tumor necrosis factor receptor superfamily member 10B (Protein name ), TR10B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

TNFRSF10B(UNQ160/PRO186;DR5;KILLER;TRAILR2;TRICK2;ZTNFR9);

Protein name:

Tumor necrosis factor receptor superfamily member 10B;

Alternative:

TNF-related apoptosis-inducing ligand receptor 2(TRAIL receptor 2;TRAIL-R2);Death receptor 5;

CD:

CD262;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotrimer. Can interact with TRADD and RIPK1.

Function:

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

440

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

440:

TLLDALETLG | ERLAKQKIED | HLLSSGKFMY | LEGNADSAMS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8795

SMR:

O14763

MIM:

275355

STRING:

9606.ENSP00000276431

UniGene:

Hs.521456

Pfam:

PF00531

String:

O14763

Uniprot:

O14763

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 10B

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E8953h

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96T

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ELISA Kit for Human Tumor necrosis factor receptor superfamily member 10B

Cat.:

E8953m

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Packing:

96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 10B

Cat.:

U8953h

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Packing:

96T

CLIA Kit for Human Tumor necrosis factor receptor superfamily member 10B

Cat.:

U8953m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10B

Cat.:

P8953Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10B

Cat.:

P8953Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Tumor necrosis factor receptor superfamily member 10B

Protein for Human Tumor necrosis factor receptor superfamily member 10B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL."
Screaton G.R. , Mongkolsapaya J. , Xu X.-N. , Cowper A.E. , McMichael A.J. , Bell J.I.
Curr. Biol.7:693-696(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT);ALTERNATIVE SPLICING;VARIANTS LEU-32; VAL-67 AND ALA-191
2.

"TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL."
Walczak H. , Degli-Esposti M.A. , Johnson R.S. , Smolak P.J. , Waugh J.Y. , Boiani N. , Timour M.S. , Gerhart M.J. , Schooley K.A. , Smith C.A. , Goodwin R.G. , Rauch C.T.
EMBO J.16:5386-5397(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);PROTEIN SEQUENCE OF N-TERMINUS;VARIANT ALA-191
tissue: Foreskin fibroblast.
3.

"Characterization of two receptors for TRAIL."
Schneider P. , Bodmer J.-L. , Thome M. , Hofmann K. , Holler N. , Tschopp J.
FEBS Lett.416:329-334(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);CHARACTERIZATION;VARIANTS LEU-32; VAL-67 AND ALA-191
tissue: Liver.
tissue: Spleen.
4.

"Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway."
Chaudhary P.M. , Eby M. , Jasmin A. , Bookwalter A. , Murray J. , Hood L.
Immunity7:821-830(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANTS LEU-32 AND VAL-67
5.

"Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL."
MacFarlane M. , Ahmad M. , Srinivasula S.M. , Fernandes-Alnemri T. , Cohen G.M. , Alnemri E.S.
J. Biol. Chem.272:25417-25420(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANTS LEU-32 AND VAL-67
6.

"KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene."
Wu G.S. , Burns T.F. , McDonald E.R. III , Jiang W. , Meng R. , Krantz I.D. , Kao G. , Gan D.D. , Zhou J.Y. , Muschel R. , Hamilton S.R. , Spinner N.B. , Markowitz S. , Wu G. , el-Deiry W.S.
Nat. Genet.17:141-143(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
tissue: Ovary.
7.

"An antagonist decoy receptor and a death domain-containing receptor for TRAIL."
Pan G. , Ni J. , Wei Y.-F. , Yu G.-L. , Gentz R. , Dixit V.M.
Science277:815-818(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
8.

"Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors."
Sheridan J.P. , Marsters S.A. , Pitti R.M. , Gurney A. , Skubatch M. , Baldwin D.T. , Ramakrishnan L. , Gray C.L. , Baker K. , Wood W.I. , Goddard A.D. , Godowski P.J. , Ashkenazi A.
Science277:818-821(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANT LEU-32
9.

"Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas."
Arai T. , Akiyama Y. , Okabe S. , Saito K. , Iwai T. , Yuasa Y.
Cancer Lett.133:197-204(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING;VARIANTS LEU-32; VAL-67 AND ALA-191
10.

Cao X. , Zhang W. , Wan T.
Submitted (1999-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
11.

"Homo sapiens homolog of tumor necrosis factor receptor."
Farrah T. , Vu T. , Gilbert T. , Gross J. , O'Hara P.
Submitted (1999-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANTS LEU-32 AND VAL-67
12.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT);VARIANT LEU-32
13.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT LEU-32
tissue: Colon endothelium.
14.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
15.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG);VARIANTS LEU-32 AND ALA-191
tissue: Cervix.
16.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
17.

"CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells."
Yamaguchi H. , Wang H.G.
J. Biol. Chem.279:45495-45502(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
18.

"Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses."
Smith W. , Tomasec P. , Aicheler R. , Loewendorf A. , Nemcovicova I. , Wang E.C. , Stanton R.J. , Macauley M. , Norris P. , Willen L. , Ruckova E. , Nomoto A. , Schneider P. , Hahn G. , Zajonc D.M. , Ware C.F. , Wilkinson G.W. , Benedict C.A.
Cell Host Microbe13:324-335(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HUMAN CYTOMEGALOVIRUS PROTEIN UL141
19.

"Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5."
Hymowitz S.G. , Christinger H.W. , Fuh G. , Ultsch M. , O'Connell M. , Kelley R.F. , Ashkenazi A. , de Vos A.M.
Mol. Cell4:563-571(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 54-183
20.

"Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation."
Mongkolsapaya J. , Grimes J.M. , Chen N. , Xu X.-N. , Stuart D.I. , Jones E.Y. , Screaton G.R.
Nat. Struct. Biol.6:1048-1053(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 69-184
21.

"Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions."
Nemcovicova I. , Benedict C.A. , Zajonc D.M.
PLoS Pathog.9:E1003224-E1003224(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 58-184;INTERACTION WITH HUMAN CYTOMEGALOVIRUS PROTEIN UL141

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