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Index > Protein center > TREM1(Gene name) > Human
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  • TREM1 (Gene name),
  • Triggering receptor expressed on myeloid cells 1 (Protein name ),  TREM1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    TREM1;
    Protein name:
    Triggering receptor expressed on myeloid cells 1(TREM-1);
    Alternative:
    Triggering receptor expressed on monocytes 1;
    CD:
    CD354;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TYROBP/DAP12.
    Function:
    Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
    Subcellular Location:
    Isoform 2 Secreted
    Protein Attributes:
    Sequence length:
    234
    Sequence:
    50:
    MRKTRLWGLL | WMLFVSELRA | ATKLTEEKYE | LKEGQTLDVK | CDYTLEKFAS | 
    100:
    SQKAWQIIRD | GEMPKTLACT | ERPSKNSHPV | QVGRIILEDY | HDHGLLRVRM | 
    150:
    VNLQVEDSGL | YQCVIYQPPK | EPHMLFDRIR | LVVTKGFSGT | PGSNENSTQN | 
    200:
    VYKIPPTTTK | ALCPLYTSPR | TVTQAPPKST | ADVSTPDSEI | NLTNVTDIIR | 
    234:
    VPVFNIVILL | AGGFLSKSLV | FSVLFAVTLR | SFVP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    MIM:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human TREM-1
    Cat.:
    E0213h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human TREM-1
    Cat.:
    E0213b
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human TREM-1
    Cat.:
    E0213m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human TREM-1
    Cat.:
    E0213p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TREM-1
    Cat.:
    U0213h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human TREM-1
    Cat.:
    U0213m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TREM-1
    Cat.:
    U0213p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human TREM-1
    Cat.:
    U0213b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human TREM-1
    Cat.:
    P0213Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TREM-1
    Cat.:
    P0213Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human TREM-1
    Polyclonal Antibody for Human TREM-1
    Monoclonal Antibody for Human TREM-1
    Monoclonal Antibody for Human TREM-1
    Monoclonal Antibody for Human TREM-1
    Monoclonal Antibody for Human TREM-1
    Protein for Human TREM-1
    Protein for Human TREM-1
    Protein for Human TREM-1
    Protein for Human TREM-1

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    References
    1. 1.
      "Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes."
      Bouchon A. , Dietrich J. , Colonna M.
      J. Immunol.164:4991-4995(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INDUCTION;TISSUE SPECIFICITY;GLYCOSYLATION;INTERACTION WITH TYROBP/DAP12
      tissue: Monocyte.
      tissue: Neutrophil.
    2. 2.
      "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development."
      Gingras M.-C. , Lapillonne H. , Margolin J.F.
      Mol. Immunol.38:817-824(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY
    3. 3.
      "Identification of a soluble form of TREM1 (sTREM1) from dendritic cells."
      Begum N.A. , Seya T.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Synovium.
    5. 5.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    7. 7.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-200;VARIANT SER-25
      tissue: Synovial cell.
    8. 8.
      "TREM-1 amplifies inflammation and is a crucial mediator of septic shock."
      Bouchon A. , Facchetti F. , Weigand M.A. , Colonna M.
      Nature410:1103-1107(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Crystal structure of the human myeloid cell activating receptor TREM-1."
      Radaev S. , Kattah M. , Rostro B. , Colonna M. , Sun P.D.
      Structure11:1527-1535(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 17-134
    10. 10.
      "Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A."
      Kelker M.S. , Foss T.R. , Peti W. , Teyton L. , Kelly J.W. , Wuethrich K. , Wilson I.A.
      J. Mol. Biol.342:1237-1248(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.47 ANGSTROMS) OF 21-139;SUBUNIT
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-97
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