Protein name:
Thioredoxin-interacting protein ;
Alternative:
Vitamin D3 up-regulated protein 1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1. Interacts (via C-terminus) with ITCH (via WW domains).
Function:
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MVMFKKIKSF | EVVFNDPEKV | YGSGEKVAGR | VIVEVCEVTR | VKAVRILACG |
100:
VAKVLWMQGS | QQCKQTLDYL | RYEDTLLLEE | QPTAGENEMV | IMRPGNKYEY |
150:
KFGFELPQGP | LGTSFKGKYG | CVDYWVKAFL | DRPSQPTQEA | KKNFEVMDLV |
200:
DVNTPDLMAP | VSAKKEKKVS | CMFIPDGRVS | VSARIDRKGF | CEGDDISIHA |
250:
DFENTCSRIV | VPKAAIVARH | TYLANGQTKV | FTQKLSSVRG | NHIISGTCAS |
300:
WRGKSLRVQK | IRPSILGCNI | LKVEYSLLIY | VSVPGSKKVI | LDLPLVIGSR |
350:
SGLSSRTSSM | ASRTSSEMSW | IDLNIPDTPE | APPCYMDIIP | EDHRLESPTT |
397:
PLLDDVDDSQ | DSPIFMYAPE | FQFMPPPTYT | EVDPCVLNNN | NNNNNVQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Pig
ELISA Kit for Mouse Thioredoxin-interacting protein
ELISA Kit for Mouse Thioredoxin-interacting protein
ELISA Kit for Mouse Thioredoxin-interacting protein
ELISA Kit for Mouse Thioredoxin-interacting protein
CLIA Kit for Mouse Thioredoxin-interacting protein
CLIA Kit for Mouse Thioredoxin-interacting protein
CLIA Kit for Mouse Thioredoxin-interacting protein
CLIA Kit for Mouse Thioredoxin-interacting protein
Polyclonal Antibody for Mouse Thioredoxin-interacting protein
Polyclonal Antibody for Mouse Thioredoxin-interacting protein
Polyclonal Antibody for Mouse Thioredoxin-interacting protein
Polyclonal Antibody for Mouse Thioredoxin-interacting protein
Monoclonal Antibody for Mouse Thioredoxin-interacting protein
Monoclonal Antibody for Mouse Thioredoxin-interacting protein
Monoclonal Antibody for Mouse Thioredoxin-interacting protein
Monoclonal Antibody for Mouse Thioredoxin-interacting protein
Protein for Mouse Thioredoxin-interacting protein
Protein for Mouse Thioredoxin-interacting protein
Protein for Mouse Thioredoxin-interacting protein
Protein for Mouse Thioredoxin-interacting protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
References
1.
"Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function."
Junn E.
,
Han S.H.
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Im J.Y.
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Yang Y.
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Cho E.W.
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Um H.D.
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J. Immunol.164:6287-6295(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH TXN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2)
strain :
C57BL/6 .
3.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
strain :
NOD .
tissue :
Cerebellum .
tissue :
Lung .
tissue :
Thymus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
Czech II .
tissue :
Mammary tumor .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH COPS5
6.
"VDUP1 is required for the development of natural killer cells."
Lee K.N.
,
Kang H.S.
,
Jeon J.H.
,
Kim E.M.
,
Yoon S.R.
,
Song H.
,
Lyu C.Y.
,
Piao Z.H.
,
Kim S.U.
,
Han Y.H.
,
Song S.S.
,
Lee Y.H.
,
Song K.S.
,
Kim Y.M.
,
Yu D.Y.
,
Choi I.
Immunity22:195-208(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE