Gene name:
UBE2V2 (MMS2;UEV2) ;
Protein name:
Ubiquitin-conjugating enzyme E2 variant 2 ;
Alternative:
Enterocyte differentiation-associated factor 1 (EDAF-1) ;DDVit 1 ;MMS2 homolog ;Enterocyte differentiation-promoting factor 1 (EDPF-1) ;Vitamin D3-inducible protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer with UBE2N. Binds CHFR.
Function:
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Subcellular Location:
N/A
Protein Attributes:
50:
MAVSTGVKVP | RNFRLLEELE | EGQKGVGDGT | VSWGLEDDED | MTLTRWTGMI |
100:
IGPPRTNYEN | RIYSLKVECG | PKYPEAPPSV | RFVTKINMNG | INNSSGMVDA |
145:
RSIPVLAKWQ | NSYSIKVVLQ | ELRRLMMSKE | NMKLPQPPEG | QTYNN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Mouse
Chicken
Rat
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;TISSUE SPECIFICITY
tissue :
Blood .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
tissue :
Colon carcinoma .
3.
"Isolation and characterization of a putative human enterocyte differentiation promoting factor (EDPF-1)."
Faria J.
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Wild G.E.
Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
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Chen X.
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Rolfs A.
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Halleck A.
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Hines L.
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Eisenstein S.
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Koundinya M.
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Kelley T.
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LaBaer J.
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Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Bone marrow .
tissue :
Urinary bladder .
tissue :
Uterus .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-11
tissue :
Platelet .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH UBE2N
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH UBE2N AND CHFR
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
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Lasa M.
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Polevoda B.
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Gazquez C.
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Elosegui-Artola A.
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Kim D.S.
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Timmerman E.
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Prieto J.
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Arnesen T.
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Sherman F.
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Gevaert K.
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Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (4.8 ANGSTROMS) OF 1-144 IN COMPLEX WITH RNF8 AND UBE2N
15.
"OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function."
Juang Y.C.
,
Landry M.C.
,
Sanches M.
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Vittal V.
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Leung C.C.
,
Ceccarelli D.F.
,
Mateo A.R.
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Pruneda J.N.
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Mao D.Y.
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,
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Mol. Cell45:384-397(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 25-271 IN COMPLEX WITH UBE2N AND OTUB1