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Index > Protein center > UBE2V2(Gene name) > Human
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  • UBE2V2 (Gene name),
  • Ubiquitin-conjugating enzyme E2 variant 2 (Protein name ),  UB2V2_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    UBE2V2(MMS2;UEV2);
    Protein name:
    Ubiquitin-conjugating enzyme E2 variant 2;
    Alternative:
    Vitamin D3-inducible protein;MMS2 homolog;Enterocyte differentiation-promoting factor 1(EDPF-1);DDVit 1;Enterocyte differentiation-associated factor 1(EDAF-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer with UBE2N. Binds CHFR.
    Function:
    Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    145
    Sequence:
    50:
    MAVSTGVKVP | RNFRLLEELE | EGQKGVGDGT | VSWGLEDDED | MTLTRWTGMI | 
    100:
    IGPPRTNYEN | RIYSLKVECG | PKYPEAPPSV | RFVTKINMNG | INNSSGMVDA | 
    145:
    RSIPVLAKWQ | NSYSIKVVLQ | ELRRLMMSKE | NMKLPQPPEG | QTYNN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    String:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 variant 2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 variant 2
    Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
    Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
    Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
    Protein for Human Ubiquitin-conjugating enzyme E2 variant 2
    Protein for Human Ubiquitin-conjugating enzyme E2 variant 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular Cloning of a 1alpha,25-dihydroxyvitamin D3 inducible transcript (DDVit 1) in human blood monocytes."
      Fritsche J. , Rehli M. , Krause S.W. , Andreesen R. , Kreutz M.
      Biochem. Biophys. Res. Commun.235:407-412(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;TISSUE SPECIFICITY
      tissue: Blood.
    2. 2.
      "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family."
      Xiao W. , Lin S.L. , Broomfield S. , Chow B.L. , Wei Y.-F.
      Nucleic Acids Res.26:3908-3914(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
      tissue: Colon carcinoma.
    3. 3.
      "Isolation and characterization of a putative human enterocyte differentiation promoting factor (EDPF-1)."
      Faria J. , Wild G.E.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Bone marrow.
      tissue: Urinary bladder.
      tissue: Uterus.
    7. 7.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11
      tissue: Platelet.
    8. 8.
      "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair."
      Hofmann R.M. , Pickart C.M.
      Cell96:645-653(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBE2N
    9. 9.
      "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains."
      Bothos J. , Summers M.K. , Venere M. , Scolnick D.M. , Halazonetis T.D.
      Oncogene22:7101-7107(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBE2N AND CHFR
    10. 10.
      "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."
      David Y. , Ziv T. , Admon A. , Navon A.
      J. Biol. Chem.285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    13. 13.
      "Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13."
      Moraes T.F. , Edwards R.A. , McKenna S. , Pastushok L. , Xiao W. , Glover J.N.M. , Ellison M.J.
      Nat. Struct. Biol.8:669-673(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)
    14. 14.
      "Molecular insights into the function of RING Finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation."
      Campbell S.J. , Edwards R.A. , Leung C.C. , Neculai D. , Hodge C.D. , Dhe-Paganon S. , Glover J.N.
      J. Biol. Chem.287:23900-23910(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.8 ANGSTROMS) OF 1-144 IN COMPLEX WITH RNF8 AND UBE2N
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 25-271 IN COMPLEX WITH UBE2N AND OTUB1
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