Protein name:
Ubiquitin-conjugating enzyme E2 B ;
Alternative:
Ubiquitin carrier protein B ;RAD6 homolog B (HR6B) ;Ubiquitin-protein ligase B ;Ubiquitin-conjugating enzyme E2(14k) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with RAD18, UBR2 and WAC.
Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
Subcellular Location:
Cell membrane
Nucleus
In peripheral neurons, expressed both at the plasma membrane and in nuclei.
Protein Attributes:
50:
MSTPARRRLM | RDFKRLQEDP | PVGVSGAPSE | NNIMQWNAVI | FGPEGTPFED |
100:
GTFKLVIEFS | EEYPNKPPTV | RFLSKMFHPN | VYADGSICLD | ILQNRWSPTY |
150:
DVSSILTSIQ | SLLDEPNPNS | PANSQAAQLY | QENKREYEKR | VSAIVEQSWN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
Rabbit
ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
Protein for Rat Ubiquitin-conjugating enzyme E2 B
Protein for Rat Ubiquitin-conjugating enzyme E2 B
Protein for Rat Ubiquitin-conjugating enzyme E2 B
Protein for Rat Ubiquitin-conjugating enzyme E2 B
Protein for Rat Ubiquitin-conjugating enzyme E2 B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY
3.
"Isolation of a ubiquitin-conjugating enzyme gene induced following cerebral ischemia from the rat brain using modified subtractive hybridization and differential screening."
Chen D.
,
Graham S.H.
,
Jing K.
,
Simon R.P.
,
Chen J.
Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Heart .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION;SUBCELLULAR LOCATION;FUNCTION