Gene name:
Ubr4(Kiaa0462;Zubr1);
Protein name:
E3 ubiquitin-protein ligase UBR4;
Alternative:
Zinc finger UBR1-type protein 1;N-recognin-4;p600;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with RB1 and calmodulin.
Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions.
Subcellular Location:
Membrane
Multi-pass membrane protein
Cytoplasm
Cytoplasm
cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.
Protein Attributes:
50:
MATSGGEEAA | AAAPAPGAPA | TGQDTTPGWE | VAVRPLLSAS | YSAFEMKELP |
100:
QLVASVIESE | SEILHHEKQY | EPFYSSFVAL | STHYITTVCS | LIPRNQLQSV |
150:
AAACKVLIEF | SLLRLENPDE | ACAVSQKHLI | LLIKGLCTGC | SRLDRTEIIT |
200:
FTAMMKSAKL | PQTVKTLSDV | EDQKELASPV | SPELRQKEVQ | MNFLNQLTSV |
250:
FNPRTVPSPP | ISPQALVEGE | NDEQSSPDQV | SAAKTKSVFI | AQNVASLQEL |
300:
GGSEKLLRVC | LNLPYFLRYI | NRFQDAVVAN | SFFIMPATVA | DATAVRNGFH |
350:
SLVIDVTMAL | DTLSLPVLEP | LNPSRLQDVT | VLSLSCLYAG | VSVATCMAIL |
400:
HVGSAQQVRT | GSTSSKEDDY | ESDAATIVQK | CLEIYDMIGQ | AISSSRRAGG |
450:
EHFQNFQLLG | AWCLLNSLFL | ILNLSPTALA | DKGKEKDPLA | ALRVRDILSR |
500:
TKEGVGSPKL | GPGKGHQGFG | VLSVILANHA | IKLLASLFQD | LQVEALHKGW |
550:
ETDGPPAVLS | IMAQSTSTQR | IQRLIDSVPL | TNLLLTLLST | SYRKACVLQR |
600:
QRKGSMSSDA | SASTDSNTYY | EDDFSSTEED | SSQDDDSEPI | LGQWFEETIS |
650:
PSKEKAAPPP | PPPPPPLESS | PRVKSPNKQA | SGEKGNILAS | RKDPELFSGL |
700:
ASNILNFITT | SMLNSRNSFI | RSYLSASLSE | HHMATLASII | KEVDKDGLKG |
750:
SSDEDFAAAL | YHFNHSLVTS | DLQSPNLQNT | LLQQLGVAPF | SEGPWPLYIH |
800:
PQGLSVLSRL | LLIWQHKAGA | QGDPDVPECL | KVWDRFLTTM | KQNALQGVVP |
850:
SETEDLNVEH | LQLLLLIFHS | FSEKGRRAIL | TMLVQSIQEL | SVNMEVQMRT |
900:
APLILARLLL | IFDYLLHQYS | KAPVYLFEQV | QHNLLSPPFG | WASGSQDSSS |
950:
RRANTPLYHG | FKEVEENWSK | HFSSDAAPQP | RFYCVLSTEA | SEEDLNRLDS |
1000:
EACEVLFSKP | VKYDELYSSL | TTLLAAGSQL | DTTRRKEKKN | VTALEACALQ |
1050:
YYFLILWRIL | GILPPSKTYM | NQLAMNSPEM | SECDILHTLR | WSSRLRISSY |
1100:
VSWIKDHLIK | QGMKPEHAGS | LIELAASKCS | SVKYDVEIVE | EYFARQISSF |
1150:
CSIDCTAVLQ | LHEIPSLQSI | YTLDAAVSKV | QVSLDEHFSK | MAAETDPHKS |
1200:
SEITKNLLPA | TLQLIDTYAS | FTRAYLLQNL | NEEGSTEKPS | QEKLHGFAAV |
1250:
LAIGSSRCKA | NTLGPTLVQN | LPSSVQSVCE | SWNNINTNEF | PNIGSWRNAF |
1300:
ANDTIPSESY | ISAVQAAHLG | TLCGQSLPLA | ASLKHTLLSL | VRLTGDLIVW |
1350:
SDEMNPAQVI | RTLLPLLLES | STESAAEISS | NSLERILGPA | ESDEFLARVY |
1400:
EKLITGCYNI | LANHADPNSG | LDESILEECL | QYLEKQLESS | QARKAMEEFF |
1450:
SDGGELVQIM | MATANEDLSA | KFCNRVLKFF | TKLFQLTEKS | PNPSLLHLCG |
1500:
SLAQLACVEP | VRLQAWLTRM | TTSPPKDSDQ | LEVIQENRQL | LQLLTTYIVR |
1550:
ENSQVGEGVC | AVLLGTLTPM | ATDMLANGDG | TGFPELMVVM | ATLASAGQGA |
1600:
GHLQLHNAAV | DWLGRCKKYL | SQKNVVEKLN | ANVMHGKHVM | VLECTCHIMS |
1650:
YLADVTNALS | QSNGQGPSHL | SVDGEERAIE | VDSDWVEELA | VEEEDSQAED |
1700:
SDEDSLCNKL | CTFTITQKEF | MNQHWYHCHT | CKMVDGVGVC | TVCAKVCHKD |
1750:
HEISYAKYGS | FFCDCGAKED | GSCLALVKRT | PSSGMSSTMK | ESAFQSEPRV |
1800:
SESLVRHAST | SPADKAKVTI | SDGKVTDEEK | PKKSSLCRTV | EGCREELQNQ |
1850:
ANFSFAPLVL | DMLSFLMDAI | QTNFQQASAV | GSSSRAQQAL | SELHTVDKGV |
1900:
EMTDQLMVPT | LGSQEGAFEN | VRMNYSGDQG | QTIRQLISAH | VLRRVAMCVL |
1950:
SSPHGRRQHL | AVSHEKGKIT | VLQLSALLKQ | ADSSKRKLTL | TRLASAPVPF |
2000:
TVLSLTGNPC | KEDYLAVCGL | KDCHVLTFSS | SGSVSDHLVL | HPQLATGNFI |
2050:
IKAVWLPGSQ | TELAIVTADF | VKIYDLSIDA | LSPTFYFLLP | SSKIRDVTFL |
2100:
FNEEGKNIIV | IMSSAGYMYT | QLMEEASSAQ | QGPFYVTNVL | EINHEDLKDS |
2150:
NSQVAGGGVS | VYYSHVLQML | FFSYSQGRSF | AATVSRSTLE | VLQLFPINIK |
2200:
SSNGGSKTSP | ALCQWSEVMN | HPGLVCCVQQ | TTGVPLVVMV | KPGTFLIQEI |
2250:
KTLPAKAKIQ | DMVAIRHTAC | NEQQRTTMIL | LCEDGSLRIY | MANVENTSYW |
2300:
LQPSLQPSSV | ISIMKPVRKR | KTATITARTS | SQVTFPIDFF | EHNQQLTDVE |
2350:
FGGNDLLQVY | NAQQIKHRLN | STGMYVANTK | PGGFTIEISN | NSSTMVMTGM |
2400:
RIQIGTQAIE | RAPSYIEIFG | RTMQLNLSRS | RWFDFPFTRE | EALQADRKLS |
2450:
LFIGASVDPA | GVTMIDAVKI | YGKTKEQFGW | PDEPPEDFPS | ASVSNICPPN |
2500:
LNQSNGTGES | DSAAPATTSG | TVLERLVVSS | LEALESCFAV | GPIIEKERNK |
2550:
HAAQELATLL | LSLPAPASVQ | QQSKSLLASL | HSSRSAYHSH | KDQALLSKAV |
2600:
QCLNTSSKEG | KDLDPEVFQR | LVITARSIAV | TRPNNLVHFT | ESKLPQMETE |
2650:
GADEGKEPQK | QEGDGCSFIT | QLVNHFWKLH | ASKPKNAFLA | PACLPGLTHI |
2700:
EATVNALVDI | IHGYCTCELD | CINTASKIYM | QMLLCPDPAV | SFSCKQALIR |
2750:
VLRPRNKRRH | VTLPSSPRSN | TPMGDKDDDD | DDDADEKMQS | SGIPDGGHIR |
2800:
QESQEQSEVD | HGDFEMVSES | MVLETAENVN | NGNPSPLEAL | LAGAEGFPPM |
2850:
LDIPPDADDE | TMVELAIALS | LQQDQQGSSS | SALGLQSLGL | SGQAPSSSSL |
2900:
DAGTLSDTTA | SAPASDDEGS | TAATDGSTLR | TSPADHGGSV | GSESGGSAVD |
2950:
SVAGEHSVSG | RSSAYGDATA | EGHPAGPGSV | SSSTGAISTA | TGHQEGDGSE |
3000:
GEGEGEAEGD | VHTSNRLHMV | RLMLLERLLQ | TLPQLRNVGG | VRAIPYMQVI |
3050:
LMLTTDLDGE | DEKDKGALDN | LLAQLIAELG | MDKKDVSKKN | ERSALNEVHL |
3100:
VVMRLLSVFM | SRTKSGSKSS | ICESSSLISS | ATAAALLSSG | AVDYCLHVLK |
3150:
SLLEYWKSQQ | SDEEPVAASQ | LLKPHTTSSP | PDMSPFFLRQ | YVKGHAADVF |
3200:
EAYTQLLTEM | VLRLPYQIKK | IADTSSRIPP | PVFDHSWFYF | LSEYLMIQQT |
3250:
PFVRRQVRKL | LLFICGSKEK | YRQLRDLHTL | DSHVRGIKKL | LEEQGIFLRA |
3300:
SVVTASSGSA | LQYDTLISLM | EHLKACAEIA | AQRTINWQKF | CIKDDSVLYF |
3350:
LLQVSFLVDE | GVSPVLLQLL | SCALCGSKVL | AALAASTGSS | SVASSSAPPA |
3400:
ASSGQATTQS | KSSTKKSKKE | EKEKEKEGES | SGSQEDQLCT | ALVNQLNRFA |
3450:
DKETLIQFLR | CFLLESNSSS | VRWQAHCLTL | HIYRNSNKAQ | QELLLDLMWS |
3500:
IWPELPAYGR | KAAQFVDLLG | YFSLKTAQTE | KKLKEYSQKA | VEILRTQNHI |
3550:
LTNHPNSNIY | NTLSGLVEFD | GYYLESDPCL | VCNNPEVPFC | YIKLSSIKVD |
3600:
TRYTTTQQVV | KLIGSHTISK | VTVKIGDLKR | TKMVRTINLY | YNNRTVQAIV |
3650:
ELKNKPARWH | KAKKVQLTPG | QTEVKIDLPL | PIVASNLMIE | FADFYENYQA |
3700:
STETLQCPRC | SASVPANPGV | CGNCGENVYQ | CHKCRSINYD | EKDPFLCNAC |
3750:
GFCKYARFDF | MLYAKPCCAV | DPIENEEDRK | KAVSNINTLL | DKADRVYHQL |
3800:
MGHRPQLENL | LCKVNEAAPE | KPQEDSGTAG | GISSTSASVN | RYILQLAQEY |
3850:
CGDCKNSFDE | LSKIIQKVFA | SRKELLEYDL | QQREAATKSS | RTSVQPTFTA |
3900:
SQYRALSVLG | CGHTSSTKCY | GCASAVTEHC | ITLLRALATN | PALRHILVSQ |
3950:
GLIRELFDYN | LRRGAAAIRE | EVRQLMCLLT | RDNPEATQQM | NDLIIGKVST |
4000:
ALKGHWANPD | LASSLQYEML | LLTDSISKED | SCWELRLRCA | LSLFLMAVNI |
4050:
KTPVVVENIT | LMCLRILQKL | IKPPAPTSKK | NKDVPVEALT | TVKPYCNEIH |
4100:
AQAQLWLKRD | PKASYEAWKK | CLPIRGVDGN | GKSPSKSELH | RLYLTEKYVW |
4150:
RWKQFLSRRG | KRTTPLDLKL | GHNNWLRQVL | FTPATQAARQ | AACTIVEALA |
4200:
TVPSRKQQVL | DLLTSYLDEL | SVAGECAAEY | LALYQKLIAS | CHWKVYLAAR |
4250:
GVLPYVGNLI | TKEIARLLAL | EEATLSTDLQ | QGYALKSLTG | LLSSFVEVES |
4300:
IKRHFKSRLV | GTVLNGYLCL | RKLVLQRTKL | IDETQDMLLE | MLEDMTTGTE |
4350:
SETKAFMAVC | IETAKRYNLD | DYRTPVFIFE | RLCSIIYPEE | NEVTEFFVTL |
4400:
EKDPQQEDFL | QGRMPGNPYS | SNEPGIGPLM | RDIKNKICQD | CDLVALLEDD |
4450:
SGMELLVNNK | IISLDLPVAE | VYKKVWCATN | EGEPMRIVYR | MRGLLGDATE |
4500:
EFIESLDSTT | DEEEDEEEVY | RMAGVMAQCG | GLQCMLNRLA | GVKDFKQGRH |
4550:
LLTVLLKLFS | YCVKVKVNRQ | QLVKLETNTL | NVMLGTLNLA | LVAEQESKDS |
4600:
GGAAVAEQVL | SIMEIILDES | NAEPLSEDKG | NLLLTGDKDQ | LVMLLDQINS |
4650:
TFVRSNPSVL | QGLLRIIPYL | SFGEVEKMQI | LVERFKPYCS | FEKYDEDHSG |
4700:
DDKVFLDCFC | KIAAGIKNNS | NGHQLKDLIL | QKGITQNALD | YMKKHIPSAK |
4750:
NLDADIWKKF | LSRPALPFIL | RLLRGLAMQH | PATQVLIGTD | SITSLHKLEQ |
4800:
VSSDEGIGTL | AENLLEALRE | HPDVNKKIDA | ARRETRAEKK | RMAMAMRQKA |
4850:
LGTLGMTTNE | KGQVVTKTAL | LKQMEELIEE | PGLTCCICRE | GYKFQPTKVL |
4900:
GIYTFTKRVA | LEEMENKPRK | QQGYSTVSHF | NIVHYDCHLA | AVRLARGREE |
4950:
WESAALQNAN | TKCNGLLPVW | GPHVPESAFA | TCLARHNTYL | QECTGQREPT |
5000:
YQLNIHDIKL | LFLRFAMEQS | FSADTGGGGR | ESNIHLIPYI | IHTVLYVLNT |
5050:
TRATSREEKN | LQGFLEQPKE | KWTESAFDVD | GPHYFTILAL | HVLPPEQWKA |
5100:
IRVEILRRLL | VASHARAVAP | GGATRLTDKA | VKDYSAYRSS | LLFWALVDLI |
5150:
YNMFKKVPTS | NTEGGWSCSL | AEYIRHNDMP | IYEAADKALK | TFQEEFMPVE |
5180:
TFSEFLDAAG | LLSEITDPES | FLKDLLNSVP |
Vaild Sequence:
Related Databases
Uniprot: