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Index > Protein center > Vav3(Gene name) > Mouse
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  • Vav3 (Gene name),
  • Guanine nucleotide exchange factor VAV3 (Protein name ),  VAV3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Vav3;
    Protein name:
    Guanine nucleotide exchange factor VAV3(VAV-3);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with the PH domain of APS (By similarity). Interacts (via SH2 domains) with the phosphorylated form of EPHA2.
    Function:
    Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitement by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    847
    Sequence:
    50:
    MEPWKQCAQW | LIHSKVLPPN | HRVTWDSAQV | FDLAQTLRDG | VLLCQLLNNL | 
    100:
    RPHSINLKEI | NLRPQMSQFL | CLKNIRTFLA | ACCDTFGMRK | SELFEAFDLF | 
    150:
    DVRDFGKVIE | TLSRLSRTPI | ALATGIRPFP | TEESINDEDI | YKGLPDLIDE | 
    200:
    TRVEDEEDLY | DCVYGEDEGG | EVYEDLMKAE | EAQQPKSQEN | DIRSCCLAEI | 
    250:
    RQTEEKYTET | LESIEKYFMA | PLKRFLTAAE | FDSVFINIPD | LVKVHRSLMQ | 
    300:
    EIHDSIVNKD | DQNLYQVFIN | YKERLVIYGQ | YCSGVESAIS | NLDYISKTKE | 
    350:
    DVKLKLEECS | KRANNGKFTL | RDLLVVPMQR | VLKYHLLLQE | LVKHTHDPME | 
    400:
    KANLKLALDA | MKDLAQYVNE | VKRDNETLRE | IKQFQLSIEN | LNQPVLLFGR | 
    450:
    PQGDGEIRIT | TLDKHTKQER | HIFLFDLAVI | VCKRKGDNYE | MKEIIDLQQY | 
    500:
    KIANNPTTDK | ENKKWSYGFY | LIHTQGQNGL | EFYCKTKDLK | KKWLEQFEMA | 
    550:
    LSNIRPDYAD | SNFHDFKMHT | FTRVTSCRVC | QMLLRGTFYQ | GYLCFKCGAK | 
    600:
    AHKECLGRVD | NCGRVNSVEQ | GPFKPPEKRT | NGLRRASRQV | DPGLPKMQVI | 
    650:
    RNYTGTPAPG | LHEGPPLHIQ | AGDTVELLRG | DAHSVFWQGR | NLASGEVGFF | 
    700:
    PSDAVKPSPC | VPKPVDYSCQ | PWYAGPMERL | QAETELINRV | NSTYLVRHRT | 
    750:
    KESGEYAISI | KYNNEAKHIK | ILTRDGFFHI | AENRKFKSLM | ELVEYYKHHS | 
    800:
    LKEGFRTLDT | TLQFPYKEPE | QPAGQRGNRT | GNSLLSPKVL | GIAIARYDFC | 
    847:
    ARDMRELSLL | KGDMVKIYTK | MSANGWWRGE | VNGRVGWFPS | TYVEEDE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse VAV-3
    Cat.:
    E0219h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse VAV-3
    Cat.:
    E0219m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse VAV-3
    Cat.:
    U0219h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse VAV-3
    Cat.:
    U0219m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse VAV-3
    Cat.:
    P0219Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse VAV-3
    Cat.:
    P0219Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse VAV-3
    Monoclonal Antibody for Mouse VAV-3
    Protein for Mouse VAV-3
    Protein for Mouse VAV-3

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors."
      Trenkle T. , McClelland M. , Adlkofer K. , Welsh J.
      Gene245:139-149(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 1-789 (ISOFORM 3)
      tissue: Skin.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-731 (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Embryonic stomach.
      tissue: Embryonic testis.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
      tissue: Mammary tumor.
    5. 5.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 143-152;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    7. 7.
      "Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis."
      Hunter S.G. , Zhuang G. , Brantley-Sieders D.M. , Swat W. , Cowan C.W. , Chen J.
      Mol. Cell. Biol.26:4830-4842(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EPHA2
    8. 8.
      "Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils."
      Sindrilaru A. , Peters T. , Schymeinsky J. , Oreshkova T. , Wang H. , Gompf A. , Mannella F. , Wlaschek M. , Sunderkotter C. , Rudolph K.L. , Walzog B. , Bustelo X.R. , Fischer K.D. , Scharffetter-Kochanek K.
      Blood113:5266-5276(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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